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> Protein (NX_Q9NP66)
Protein (NX_Q9NP66)
Protein
Gene SymbolHMG20A to neXtProt (NX_Q9NP66)
DescriptionHigh mobility group protein 20A
Chromosome15
Location15q24.3 (77712754 ~ 77777949) to Ensembl
Sequene Features : Isoforms 2, Variants 48, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of neuron differentiation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
  + 3 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 48 3
2014-09-19protein level
2 35 3
2014-05-27protein level
2 35 3
2014-02-25protein level
2 35 3
2013-12-09protein level
2 27 3
2013-11-01protein level
2 27 3
2013-09-12protein level
2 27 3
2013-08-17protein level
2 27 3
2013-07-15protein level
2 20 2
2013-06-11protein level
2 20 2
2013-02-12protein level
2 7 2
2012-12-20protein level
2 7 2
2012-10-30protein level
2 11 2
2012-10-07protein level
2 11 2
2012-08-24protein level
2 10 2
2012-07-28protein level
2 10 2
2012-06-08protein level
2 12 2
2012-05-07protein level
2 7 2
2012-04-10protein level
2 7 2
2012-01-13protein level
2 1 2
2011-12-20protein level
2 1 2
2011-11-11protein level
2 1 1
2011-08-23protein level
2 1 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NP66-1
10 2 0 40118.947
NX_Q9NP66-2
0 2 0 8665.8571
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740641,EBI-740402 DTNB  
  .N/A .zinc ion binding .synapse
.cytoplasm
2 EBI-740641,EBI-10191924 FMNL1  
  .actin filament severing
.cortical actin cytoskeleton organization
.regulation of cell shape
  + 2 more...
.actin filament binding
.Rac GTPase binding
.GTPase activating protein binding
.extracellular exosome
.phagocytic vesicle
.bleb
  + 4 more...
3 EBI-740641,EBI-10206868 ADD1  
  .cellular response to retinoic acid
.transmembrane transport
.actin filament bundle assembly
  + 18 more...
.actin filament binding
.protein heterodimerization activity
.poly(A) RNA binding
  + 5 more...
.perinuclear region of cytoplasm
.intermediate filament cytoskeleton
.dendritic spine
  + 7 more...
4 EBI-740641,EBI-749311 HPCAL1  
  .signal transduction .calcium ion binding .extracellular exosome
5 EBI-740641,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
6 EBI-740641,EBI-1045772 PTH2R  
  .G-protein coupled receptor signaling pathway .parathyroid hormone receptor activity .integral component of plasma membrane
.plasma membrane
7 EBI-740641,EBI-366553 RPP30  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.RNA phosphodiester bond hydrolysis
.tRNA processing
.poly(A) RNA binding
.ribonuclease P activity
.nucleolar ribonuclease P complex
.nucleus
8 EBI-740641,EBI-740653 TESC  
  .protein targeting to plasma membrane
.cellular response to retinoic acid
.protein maturation
  + 10 more...
.protein homodimerization activity
.phosphatase inhibitor activity
.calcium ion binding
  + 2 more...
.ruffle membrane
.lamellipodium
.plasma membrane
  + 4 more...
9 EBI-740641,EBI-747142 SYTL4  
  .multivesicular body sorting pathway
.positive regulation of protein secretion
.calcium ion-dependent exocytosis of neurotransmitter
  + 6 more...
.neurexin family protein binding
.clathrin binding
.syntaxin binding
  + 4 more...
.exocytic vesicle
.transport vesicle membrane
.secretory granule
  + 6 more...
10 EBI-740641,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
11 EBI-740641,EBI-742422 CFAP53  
  .N/A .N/A .cilium
12 EBI-740641,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
13 EBI-740641,EBI-10305303 RSPH9  
  .axoneme assembly
.cilium movement
.N/A .motile cilium
.axoneme
.cytoskeleton
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
bladder33
bone97
bone marrow184
brain169
cervix144
connective tissue40
embryonic tissue98
esophagus49
eye57
heart22
intestine43
kidney42
larynx42
liver43
lung20
lymph node44
mammary gland39
mouth105
muscle56
nerve64
ovary68
pancreas89
parathyroid48
pharynx122
placenta88
prostate5
skin75
spleen112
stomach10
testis213
thymus213
thyroid21
trachea540
uterus180
vascular77
Health State
TissuesTPM*
normal99
adrenal tumor237
breast (mammary gland) tumor53
cervical tumor173
chondrosarcoma48
colorectal tumor35
esophageal tumor57
gastrointestinal tumor16
germ cell tumor212
glioma18
head and neck tumor67
kidney tumor43
leukemia10
liver tumor83
lung tumor19
lymphoma27
non-neoplasia31
ovarian tumor65
pancreatic tumor47
primitive neuroectodermal tumor of the CNS70
retinoblastoma21
skin tumor63
soft tissue/muscle tissue tumor55
uterine tumor33
Developmental Stage
TissuesTPM*
adult66
embryoid body128
blastocyst113
neonate32
fetus118
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.8
adrenal gland20.2
appendix19.7
bone marrow7.5
cerebral cortex24.9
colon16.4
duodenum12.9
esophagus13
gallbladder17.8
heart muscle20.2
kidney14.1
liver15.7
lung18.4
lymph node25.5
ovary22.1
pancreas7.6
placenta18.2
prostate13.2
salivary gland11
skin12.9
small intestine15.5
spleen36.7
stomach15.8
testis24.2
thyroid gland17
urinary bladder19.4
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverLow
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1High
small intestineHigh
smooth muscleLow
soft tissue 1High
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605534, gene) High mobility group protein 20a; HMG20AOMIM


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