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> Protein (NX_Q9NP84)
Protein (NX_Q9NP84)
Protein
Gene SymbolTNFRSF12A to neXtProt (NX_Q9NP84)
DescriptionTumor necrosis factor receptor superfamily member 12A
Chromosome16
Location16p13.3 (3068446 ~ 3072384) to Ensembl
Sequene Features : Isoforms 2, Variants 12, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of extrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
.regulation of wound healing
  + 5 more...
.N/A .integral component of membrane
.cell surface
.plasma membrane
.ruffle
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 12 3
2014-09-19protein level
2 10 3
2014-05-27protein level
2 10 3
2014-02-25protein level
2 10 3
2013-12-09protein level
2 5 3
2013-11-01protein level
2 5 3
2013-09-12protein level
2 5 3
2013-08-17protein level
2 5 3
2013-07-15protein level
2 5 3
2013-06-11protein level
2 5 3
2013-02-12protein level
2 4 3
2012-12-20protein level
2 4 3
2012-10-30protein level
2 4 3
2012-10-07protein level
2 4 3
2012-08-24protein level
2 4 3
2012-07-28protein level
2 4 3
2012-06-08protein level
2 4 3
2012-05-07protein level
2 3 3
2012-04-10protein level
2 3 3
2012-01-13protein level
2 0 3
2011-12-20protein level
2 0 3
2011-11-11protein level
2 0 3
2011-08-23protein level
2 0 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NP84-1
4 3 0 13902.1991
NX_Q9NP84-2
1 3 0 10184.6958
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2851995,EBI-6932080 TNFSF12  
  .positive regulation of extrinsic apoptotic signaling pathway
.apoptotic signaling pathway
.positive regulation of angiogenesis
  + 8 more...
.cytokine activity
.receptor binding
.perinuclear region of cytoplasm
.integral component of plasma membrane
.extracellular space
2 EBI-2851995,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
3 EBI-2851995,EBI-514538 BIRC2  
  .regulation of reactive oxygen species metabolic process
.regulation of cysteine-type endopeptidase activity
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
  + 40 more...
.protein N-terminus binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 3 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
4 EBI-2851995,EBI-8644112 SLC30A2  
  .positive regulation of sequestering of zinc ion
.transmembrane transport
.zinc II ion transport
.cation transmembrane transporter activity .integral component of membrane
.late endosome
.lysosomal membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
blood16
bone41
brain8
cervix41
connective tissue33
embryonic tissue75
eye33
heart11
intestine56
kidney109
liver9
lung74
lymph node89
mammary gland119
muscle9
ovary49
pancreas131
pituitary gland60
placenta77
prostate42
salivary gland246
skin147
stomach292
testis2
thyroid21
uterus47
vascular38
Health State
TissuesTPM*
normal27
bladder carcinoma56
breast (mammary gland) tumor150
chondrosarcoma156
colorectal tumor62
gastrointestinal tumor261
germ cell tumor7
glioma65
head and neck tumor44
kidney tumor203
leukemia10
lung tumor116
ovarian tumor13
pancreatic tumor180
prostate cancer19
retinoblastoma21
skin tumor231
soft tissue/muscle tissue tumor7
uterine tumor99
Developmental Stage
TissuesTPM*
adult49
embryoid body200
blastocyst32
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.6
adrenal gland21.3
appendix25.8
bone marrow6.4
cerebral cortex4.6
colon9.6
duodenum26.3
esophagus5.6
gallbladder53.9
heart muscle51.4
kidney19.5
liver33.1
lung37.4
lymph node2.5
ovary1.6
pancreas53.7
placenta40.3
prostate15.4
salivary gland10.4
skin4.8
small intestine19.1
spleen2.7
stomach19.3
testis5
thyroid gland8.1
urinary bladder19
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605914, gene) Tumor necrosis factor receptor superfamily, member 12a; TNFRSF12AOMIM


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