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> Protein (NX_Q9NPB6)
Protein (NX_Q9NPB6)
Protein
Gene SymbolPARD6A to neXtProt (NX_Q9NPB6)
DescriptionPartitioning defective 6 homolog alpha
Chromosome16
Location16q22.1 (67694849 ~ 67696681) to Ensembl
Sequene Features : Isoforms 2, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.tight junction assembly
.cell division
.cell-cell junction maintenance
  + 5 more...
.GTP-dependent protein binding
.Rho GTPase binding
.transcription factor binding
.apical part of cell
.protein complex
.cell cortex
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 25 2
2014-09-19protein level
2 16 2
2014-05-27protein level
2 16 2
2014-02-25protein level
2 16 2
2013-12-09protein level
2 10 2
2013-11-01protein level
2 9 2
2013-09-12protein level
2 9 2
2013-08-17protein level
2 9 2
2013-07-15protein level
2 8 2
2013-06-11protein level
2 8 2
2013-02-12protein level
2 6 4
2012-12-20protein level
2 6 4
2012-10-30protein level
2 6 4
2012-10-07protein level
2 6 2
2012-08-24protein level
2 6 2
2012-07-28protein level
2 6 2
2012-06-08protein level
2 9 2
2012-05-07protein level
2 7 2
2012-04-10protein level
2 7 2
2012-01-13protein level
2 5 2
2011-12-20protein level
2 5 2
2011-11-11protein level
2 5 2
2011-08-23protein level
2 5 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NPB6-1
1 15 1 37365.4055
NX_Q9NPB6-2
1 15 1 37294.3686
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-81876,EBI-2903122 CDH5  
  .regulation of establishment of cell polarity
.vascular endothelial growth factor receptor signaling pathway
.cell-cell junction organization
  + 5 more...
.ion channel binding
.beta-catenin binding
.calcium ion binding
.receptor binding
.cell junction
.integral component of membrane
.membrane
  + 4 more...
2 EBI-81876,EBI-286199 PRKCI  
  .positive regulation of endothelial cell apoptotic process
.positive regulation of establishment of protein localization to plasma membrane
.tight junction assembly
  + 25 more...
.metal ion binding
.phospholipid binding
.ATP binding
  + 3 more...
.extracellular exosome
.intercellular bridge
.protein complex
  + 11 more...
3 EBI-81876,EBI-81752 CDC42  
  .positive regulation of substrate adhesion-dependent cell spreading
.positive regulation of intracellular protein transport
.epithelial cell-cell adhesion
  + 61 more...
.identical protein binding
.apolipoprotein A-I receptor binding
.thioesterase binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.spindle midzone
  + 17 more...
4 EBI-10693102,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
5 EBI-81876,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
6 EBI-81876,EBI-306940 YWHAH  
  .regulation of sodium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
  + 16 more...
.protein heterodimerization activity
.ion channel binding
.glucocorticoid receptor binding
  + 4 more...
.extracellular exosome
.cytoplasmic vesicle membrane
.intercalated disc
  + 3 more...
7 EBI-81876,EBI-295351 PRKCZ  
  .positive regulation of interleukin-10 secretion
.positive regulation of interleukin-13 secretion
.positive regulation of interleukin-5 secretion
  + 38 more...
.metal ion binding
.insulin receptor substrate binding
.potassium channel regulator activity
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical cortex
  + 17 more...
8 EBI-81876,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
9 EBI-81876,EBI-81968 PARD3  
  .establishment of epithelial cell polarity
.tight junction assembly
.regulation of cellular localization
  + 18 more...
.phosphatidylinositol-3-phosphate binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.apical part of cell
.axonal growth cone
.protein complex
  + 11 more...
10 EBI-10693102,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood16
brain13
eye38
intestine17
kidney47
liver4
lung20
lymph67
lymph node11
muscle9
nerve64
ovary9
pancreas4
parathyroid97
prostate10
testis32
thymus25
Health State
TissuesTPM*
normal12
colorectal tumor17
gastrointestinal tumor8
glioma18
kidney tumor29
leukemia21
liver tumor10
lymphoma41
primitive neuroectodermal tumor of the CNS7
prostate cancer9
retinoblastoma43
Developmental Stage
TissuesTPM*
adult9
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.8
adrenal gland3.6
appendix2.3
bone marrow1.1
cerebral cortex8.2
colon2
esophagus1.7
gallbladder2.2
heart muscle1.5
kidney4.8
lung2
lymph node3
ovary1.8
pancreas11.9
prostate1.7
salivary gland1.9
small intestine1.2
spleen2.4
stomach2.1
testis15.2
thyroid gland1.4
urinary bladder2.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607484, gene) Partitioning-defective protein 6, c. elegans, homolog of, alpha; PARD6AOMIM


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