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> Protein (NX_Q9NPH2)
Protein (NX_Q9NPH2)
Protein
Gene SymbolISYNA1 to neXtProt (NX_Q9NPH2)
DescriptionInositol-3-phosphate synthase 1
Chromosome19
Location19p13.11 (18545198 ~ 18549111) to Ensembl
Sequene Features : Isoforms 3, Variants 39, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.inositol phosphate metabolic process
.phospholipid biosynthetic process
.inositol biosynthetic process
.inositol-3-phosphate synthase activity .cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 39 3
2014-09-19protein level
3 31 3
2014-05-27protein level
3 31 3
2014-02-25protein level
3 32 3
2013-12-09protein level
3 21 3
2013-11-01protein level
3 18 0
2013-09-12protein level
3 18 0
2013-08-17protein level
3 18 0
2013-07-15protein level
3 11 0
2013-06-11protein level
3 11 0
2013-02-12protein level
2 9 0
2012-12-20protein level
2 9 0
2012-10-30protein level
2 9 0
2012-10-07protein level
2 9 0
2012-08-24protein level
2 7 0
2012-07-28protein level
2 7 0
2012-06-08protein level
2 18 0
2012-05-07protein level
2 16 0
2012-04-10protein level
2 16 0
2012-01-13protein level
2 16 0
2011-12-20protein level
2 16 0
2011-11-11protein level
2 16 0
2011-08-23protein level
2 16 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NPH2-1
1 21 0 61028.9273
NX_Q9NPH2-2
1 19 0 47115.8275
NX_Q9NPH2-3
0 21 0 55100.7155
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-720563,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites50
bladder66
blood24
bone13
bone marrow82
brain68
cervix82
connective tissue40
embryonic tissue234
esophagus49
eye134
heart55
intestine25
kidney123
larynx42
liver38
lung44
lymph node11
mammary gland59
mouth15
muscle9
nerve64
ovary118
pancreas70
parathyroid242
pituitary gland121
placenta286
prostate73
skin56
spleen56
stomach73
testis537
thymus62
thyroid64
umbilical cord653
uterus94
vascular19
Health State
TissuesTPM*
normal129
breast (mammary gland) tumor85
cervical tumor57
chondrosarcoma36
colorectal tumor26
esophageal tumor57
gastrointestinal tumor50
germ cell tumor193
glioma55
head and neck tumor37
kidney tumor58
leukemia63
liver tumor31
lung tumor38
lymphoma13
non-neoplasia10
ovarian tumor131
pancreatic tumor47
primitive neuroectodermal tumor of the CNS118
prostate cancer38
retinoblastoma258
skin tumor79
soft tissue/muscle tissue tumor87
uterine tumor99
Developmental Stage
TissuesTPM*
adult96
embryoid body343
blastocyst113
neonate289
fetus86
infant127
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.3
adrenal gland24.5
appendix8
bone marrow10.9
cerebral cortex8.1
colon8
duodenum7.3
esophagus12.1
gallbladder28.4
heart muscle29.5
kidney39.8
liver5.4
lung16.8
lymph node21.9
ovary60.3
pancreas38.8
placenta143.4
prostate26.2
salivary gland21.5
skin6.1
small intestine8
spleen31.3
stomach8.6
testis189.4
thyroid gland14.2
urinary bladder24.8
Tissues
TissuesExpression level
adrenal glandLow
bone marrowLow
breastMedium
bronchusLow
cerebellumLow
cerebral cortexMedium
colonMedium
endometrium 1Low
endometrium 2Low
epididymisHigh
fallopian tubeHigh
kidneyMedium
lateral ventricleLow
liverHigh
nasopharynxLow
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumLow
seminal vesicleHigh
skeletal muscleLow
skin 1Low
stomach 2Low
testisHigh
thyroid glandLow
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611670, gene) Inositol-3-phosphate synthase 1; ISYNA1OMIM


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