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> Protein (NX_Q9NPJ6)
Protein (NX_Q9NPJ6)
Protein
Gene SymbolMED4 to neXtProt (NX_Q9NPJ6)
DescriptionMediator of RNA polymerase II transcription subunit 4
Chromosome13
Location13q14.2 (48627459 ~ 48669267) to Ensembl
Sequene Features : Isoforms 2, Variants 22, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 22 7
2014-09-19protein level
2 16 7
2014-05-27protein level
2 16 7
2014-02-25protein level
2 16 7
2013-12-09protein level
2 12 7
2013-11-01protein level
2 12 7
2013-09-12protein level
2 12 6
2013-08-17protein level
2 12 6
2013-07-15protein level
1 12 1
2013-06-11protein level
1 12 1
2013-02-12protein level
1 5 1
2012-12-20protein level
1 6 1
2012-10-30protein level
1 6 1
2012-10-07protein level
1 6 1
2012-08-24protein level
1 5 1
2012-07-28protein level
1 5 1
2012-06-08protein level
1 13 1
2012-05-07protein level
1 13 1
2012-04-10protein level
1 13 1
2012-01-13protein level
1 12 1
2011-12-20protein level
1 12 1
2011-11-11protein level
1 12 1
2011-08-23protein level
1 12 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NPJ6-1
4 11 0 29726.8386
NX_Q9NPJ6-2
0 11 0 24931.3753
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-394607,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-394607,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
3 EBI-394607,EBI-1049336 TNFAIP8  
  .defense response to Gram-positive bacterium
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
.negative regulation of apoptotic process
.interleukin-1 beta production
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process .cytoplasm
4 EBI-394607,EBI-394392 MED26  
  .gene expression
.transcription initiation from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.transcription coactivator activity
.DNA binding
.RNA polymerase II transcription cofactor activity
.mediator complex
.nucleoplasm
5 EBI-394607,EBI-10192648 FTCD  
  .small molecule metabolic process
.tetrahydrofolate interconversion
.cellular nitrogen compound metabolic process
  + 5 more...
.formimidoyltetrahydrofolate cyclodeaminase activity
.glutamate formimidoyltransferase activity
.folic acid binding
.extracellular exosome
.cytosol
.centriole
  + 2 more...
6 EBI-394607,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
7 EBI-394607,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
8 EBI-394607,EBI-10240044 LRRFIP1  
  .negative regulation of transcription, DNA-templated
.innate immune response
.positive regulation of type I interferon production
  + 2 more...
.protein homodimerization activity
.double-stranded RNA binding
.DNA binding
.plasma membrane
.cytoskeleton
.cytosol
  + 2 more...
9 EBI-394607,EBI-3891843 AMOT  
  .positive regulation of stress fiber assembly
.positive regulation of cell size
.positive regulation of blood vessel endothelial cell migration
  + 16 more...
.angiostatin binding
.receptor activity
.endocytic vesicle
.lamellipodium
.integral component of membrane
  + 8 more...
10 EBI-394607,EBI-744203 IFT20  
  .regulation of autophagic vacuole assembly
.regulation of cilium assembly
.protein localization to cilium
  + 13 more...
.N/A .ciliary base
.ciliary tip
.primary cilium
  + 13 more...
11 EBI-394607,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
12 EBI-394607,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
13 EBI-394607,EBI-10268010 MAB21L3  
  .N/A .N/A .N/A
14 EBI-394607,EBI-751248 FAM13C  
  .N/A .N/A .N/A
15 EBI-394607,EBI-747505 C1orf216  
  .N/A .N/A .N/A
16 EBI-394607,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
17 EBI-394607,EBI-748128 CTNNBL1  
  .positive regulation of apoptotic process
.somatic diversification of immunoglobulins
.gene expression
  + 3 more...
.enzyme binding .membrane
.cytoplasm
.spliceosomal complex
  + 3 more...
18 EBI-394607,EBI-394357 MED12  
  .axis elongation involved in somitogenesis
.Wnt signaling pathway, planar cell polarity pathway
.canonical Wnt signaling pathway
  + 12 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 9 more...
.mediator complex
.membrane
.centrosome
  + 3 more...
19 EBI-394607,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
20 EBI-394607,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
21 EBI-394607,EBI-743117 CCDC101  
  .establishment of protein localization to chromatin
.histone H3 acetylation
.regulation of transcription, DNA-templated
  + 2 more...
.methylated histone binding .SAGA-type complex
.Ada2/Gcn5/Ada3 transcription activator complex
22 EBI-394607,EBI-358489 SMARCD1  
  .chromatin-mediated maintenance of transcription
.nervous system development
.regulation of transcription from RNA polymerase II promoter
  + 2 more...
.protein complex scaffold
.transcription coactivator activity
.nBAF complex
.npBAF complex
.SWI/SNF complex
23 EBI-394607,EBI-741729 FRMD6  
  .cellular protein localization
.regulation of actin filament-based process
.apical constriction
.N/A .apical junction complex
.plasma membrane
.cytoskeleton
.cytoplasm
24 EBI-394607,EBI-10295431 SSX3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleic acid binding .nucleus
25 EBI-394607,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
26 EBI-394607,EBI-394653 MED9  
  .N/A .RNA polymerase II transcription cofactor activity .mediator complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites75
blood24
bone55
bone marrow20
brain7
connective tissue6
embryonic tissue4
eye9
intestine30
kidney90
liver9
lung11
lymph node22
mouth15
ovary9
parathyroid48
placenta31
prostate10
stomach20
testis11
thyroid21
uterus38
vascular19
Health State
TissuesTPM*
normal18
adrenal tumor79
bladder carcinoma682
breast (mammary gland) tumor96
cervical tumor28
chondrosarcoma84
colorectal tumor53
esophageal tumor57
gastrointestinal tumor84
germ cell tumor94
glioma55
head and neck tumor52
kidney tumor58
leukemia137
liver tumor62
lung tumor9
lymphoma27
non-neoplasia20
primitive neuroectodermal tumor of the CNS15
prostate cancer19
uterine tumor33
Developmental Stage
TissuesTPM*
adult65
embryoid body14
blastocyst65
fetus19
infant170
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue38.7
adrenal gland35.2
appendix37.2
bone marrow39
cerebral cortex27.3
colon40.4
duodenum37.2
esophagus39.6
gallbladder35.1
heart muscle41.2
kidney31.5
liver25.9
lung35.3
lymph node45.9
ovary31.6
pancreas12.7
placenta42.6
prostate33.3
salivary gland25.3
skin33.2
small intestine40.6
spleen31.8
stomach29.7
testis53.6
thyroid gland41.3
urinary bladder41.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonMedium
duodenumLow
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1Medium
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605718, gene) Mediator complex subunit 4; MED4OMIM


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