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> Protein (NX_Q9NQC3)
Protein (NX_Q9NQC3)
Protein
Gene SymbolRTN4 to neXtProt (NX_Q9NQC3)
DescriptionReticulon-4
Chromosome2
Location2p16.1 (55199325 ~ 55339757) to Ensembl
Sequene Features : Isoforms 6, Variants 153, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of branching morphogenesis of a nerve
.endoplasmic reticulum tubular network organization
.cardiac epithelial to mesenchymal transition
  + 11 more...
.poly(A) RNA binding .extracellular exosome
.neuronal cell body
.cell projection
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 153 22
2014-09-19protein level
6 131 22
2014-05-27protein level
6 131 22
2014-02-25protein level
6 130 22
2013-12-09protein level
6 92 22
2013-11-01protein level
6 91 21
2013-09-12protein level
6 91 22
2013-08-17protein level
6 91 22
2013-07-15protein level
6 63 20
2013-06-11protein level
6 63 20
2013-02-12protein level
6 43 70
2012-12-20protein level
6 37 70
2012-10-30protein level
6 42 70
2012-10-07protein level
6 42 20
2012-08-24protein level
6 35 20
2012-07-28protein level
6 35 20
2012-06-08protein level
6 39 20
2012-05-07protein level
6 39 20
2012-04-10protein level
6 39 20
2012-01-13protein level
6 22 20
2011-12-20protein level
6 22 20
2011-11-11protein level
6 22 19
2011-08-23protein level
6 22 19
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NQC3-1
1 47 0 129850.8258
NX_Q9NQC3-2
1 14 0 40292.8332
NX_Q9NQC3-3
1 8 0 22381.1938
NX_Q9NQC3-4
1 39 0 106293.8975
NX_Q9NQC3-5
1 15 0 42247.8277
NX_Q9NQC3-6
0 40 0 108382.4344
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-715945,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-715945,EBI-2822329 SNX1  
  .lamellipodium morphogenesis
.positive regulation of protein catabolic process
.retrograde transport, endosome to Golgi
  + 4 more...
.leptin receptor binding
.transferrin receptor binding
.identical protein binding
  + 3 more...
.protein complex
.intracellular membrane-bounded organelle
.early endosome membrane
  + 8 more...
3 EBI-715945,EBI-714543 ARL6IP1  
  .cotranslational protein targeting to membrane .N/A .integral component of membrane
.membrane
.cytosol
.Sec61 translocon complex
4 EBI-715945,EBI-10238936 SYT16  
  .synaptic vesicle exocytosis
.vesicle fusion
.clathrin binding
.syntaxin binding
.phospholipid binding
.calcium ion binding
.plasma membrane
5 EBI-715972,EBI-2410266 ATL1  
  .protein homooligomerization
.metabolic process
.axonogenesis
.endoplasmic reticulum organization
.identical protein binding
.GTP binding
.GTPase activity
.axon
.integral component of membrane
.Golgi apparatus
  + 4 more...
6 EBI-715945,EBI-2849569 ZFYVE21  
  .N/A .metal ion binding .cytoplasmic membrane-bounded vesicle
.focal adhesion
.endosome
7 EBI-715945,EBI-725924 SNX15  
  .intracellular protein transport .phosphatidylinositol binding .cytoplasmic vesicle membrane
.membrane
.cytosol
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland546
ascites251
bladder870
blood122
bone446
bone marrow287
brain413
cervix61
connective tissue194
ear869
embryonic tissue338
esophagus198
eye359
heart301
intestine137
kidney531
larynx170
liver267
lung304
lymph67
lymph node89
mammary gland423
mouth90
muscle1917
nerve257
ovary118
pancreas398
parathyroid339
pharynx122
pituitary gland121
placenta155
prostate247
salivary gland98
skin483
spleen112
stomach188
testis137
thymus12
thyroid64
trachea57
umbilical cord217
uterus168
vascular503
Health State
TissuesTPM*
normal343
adrenal tumor316
bladder carcinoma1023
breast (mammary gland) tumor483
cervical tumor86
chondrosarcoma301
colorectal tumor79
esophageal tumor231
gastrointestinal tumor244
germ cell tumor303
glioma391
head and neck tumor97
kidney tumor537
leukemia169
liver tumor333
lung tumor233
lymphoma96
non-neoplasia351
ovarian tumor118
pancreatic tumor390
primitive neuroectodermal tumor of the CNS125
prostate cancer240
retinoblastoma279
skin tumor406
soft tissue/muscle tissue tumor111
uterine tumor155
Developmental Stage
TissuesTPM*
adult265
embryoid body314
blastocyst162
neonate354
fetus310
infant127
juvenile287
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue378.2
adrenal gland265.5
appendix134
bone marrow69.8
cerebral cortex301.2
colon158.5
duodenum176.5
esophagus197.5
gallbladder196.1
heart muscle85.1
kidney267.9
liver222.1
lung148.7
lymph node74.5
ovary114.5
pancreas54.3
placenta137.8
prostate177
salivary gland76.2
skin198.6
small intestine222.4
spleen86.1
stomach92.5
testis69.5
thyroid gland117.7
urinary bladder213.3
Tissues
TissuesExpression level
cerebellumMedium
cerebral cortexMedium
colonHigh
hippocampusMedium
lateral ventricleHigh
soft tissue 1Medium
soft tissue 2Medium
testisHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604475, gene) Reticulon 4; RTN4OMIM


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