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> Protein (NX_Q9NQC7)
Protein (NX_Q9NQC7)
Protein
Gene SymbolCYLD to neXtProt (NX_Q9NQC7)
DescriptionUbiquitin carboxyl-terminal hydrolase CYLD
Chromosome16
Location16q12.1 (50775961 ~ 50835846) to Ensembl
Sequene Features : Isoforms 2, Variants 101, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.regulation of cilium assembly
  + 16 more...
.proline-rich region binding
.Lys63-specific deubiquitinase activity
.protein kinase binding
  + 2 more...
.ciliary tip
.perinuclear region of cytoplasm
.ciliary basal body
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 101 8
2014-09-19protein level
2 70 8
2014-05-27protein level
2 70 8
2014-02-25protein level
2 71 8
2013-12-09protein level
2 65 8
2013-11-01protein level
2 64 8
2013-09-12protein level
2 64 8
2013-08-17protein level
2 64 8
2013-07-15protein level
2 29 3
2013-06-11protein level
2 29 3
2013-02-12protein level
2 7 4
2012-12-20protein level
2 8 4
2012-10-30protein level
2 8 4
2012-10-07protein level
2 8 2
2012-08-24protein level
2 8 2
2012-07-28protein level
2 8 2
2012-06-08protein level
2 41 2
2012-05-07protein level
2 21 2
2012-04-10protein level
2 21 2
2012-01-13protein level
2 20 2
2011-12-20protein level
2 20 2
2011-11-11protein level
2 20 2
2011-08-23protein level
2 20 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NQC7-1
1 47 0 107246.4303
NX_Q9NQC7-2
1 47 0 106975.2779
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2117940,EBI-995350 DDX58  
  .positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 17 more...
.identical protein binding
.zinc ion binding
.ATP binding
  + 4 more...
.ruffle membrane
.actin cytoskeleton
.tight junction
  + 2 more...
2 EBI-2117940,EBI-302552 TUBA1A  
  .cell division
.protein polymerization
.'de novo' posttranslational protein folding
  + 7 more...
.GTP binding
.structural constituent of cytoskeleton
.structural molecule activity
.GTPase activity
.extracellular exosome
.recycling endosome
.cytoplasmic ribonucleoprotein granule
  + 4 more...
3 EBI-2117940,EBI-1564678 ITCH  
  .regulation of protein deubiquitination
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
  + 21 more...
.ubiquitin protein ligase activity
.CXCR chemokine receptor binding
.ribonucleoprotein complex binding
  + 2 more...
.extracellular exosome
.cytoplasmic vesicle
.membrane
  + 5 more...
4 EBI-2117940,EBI-301697 HDAC6  
  .positive regulation of hydrogen peroxide-mediated programmed cell death
.tubulin deacetylation
.positive regulation of chaperone-mediated protein complex assembly
  + 38 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.dynein complex binding
.Hsp90 protein binding
  + 16 more...
.perinuclear region of cytoplasm
.perikaryon
.cell leading edge
  + 13 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
blood98
bone27
bone marrow20
brain61
cervix41
connective tissue67
ear62
embryonic tissue28
eye67
heart89
intestine30
kidney28
larynx127
liver19
lung35
lymph22
lymph node167
mammary gland19
mouth15
muscle94
ovary39
pancreas74
pharynx73
placenta28
prostate89
skin23
spleen37
stomach52
testis96
thymus37
thyroid21
tonsil58
trachea77
uterus77
vascular96
Health State
TissuesTPM*
normal67
adrenal tumor158
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma120
colorectal tumor17
gastrointestinal tumor42
germ cell tumor37
glioma121
head and neck tumor37
kidney tumor14
leukemia42
liver tumor10
lung tumor9
lymphoma27
non-neoplasia10
ovarian tumor65
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
prostate cancer96
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult55
embryoid body28
blastocyst32
fetus96
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.8
adrenal gland23.6
appendix41.3
bone marrow73.1
cerebral cortex22.6
colon16.2
duodenum15.1
esophagus22.5
gallbladder22.6
heart muscle16.3
kidney12.5
liver11.3
lung19.1
lymph node52.4
ovary16.1
pancreas7.5
placenta13.2
prostate14.2
salivary gland14.7
skin13
small intestine16.5
spleen36.3
stomach20.5
testis36.6
thyroid gland25
urinary bladder27
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#132700, phenotype) Cylindromatosis, familialOMIM
2(#601606, phenotype) Trichoepithelioma, multiple familial, 1OMIM
3(*605018, gene) Cyld gene; CYLDOMIM
4(#605041, phenotype) Brooke-spiegler syndrome; BRSSOMIM
5cylindroma;Familial cylindromatosisCGP


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