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> Protein (NX_Q9NQL9)
Protein (NX_Q9NQL9)
Gene SymbolDMRT3 to neXtProt (NX_Q9NQL9)
DescriptionDoublesex- and mab-3-related transcription factor 3
Location9p24.3 (976964 ~ 991731) to Ensembl
Sequene Features : Isoforms 1, Variants 84, PTMsto neXtProt Sequence Features
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 84 0
2014-09-19protein level
1 63 0
2014-05-27protein level
1 63 0
2014-02-25protein level
1 62 0
2013-12-09protein level
1 53 0
2013-11-01protein level
1 51 0
2013-09-12protein level
1 51 0
2013-08-17protein level
1 51 0
2013-07-15protein level
1 35 0
2013-06-11protein level
1 35 0
2013-02-12protein level
1 24 0
2012-12-20protein level
1 22 0
2012-10-30protein level
1 30 0
2012-10-07protein level
1 30 0
2012-08-24protein level
1 28 0
2012-07-28protein level
1 28 0
2012-06-08protein level
1 28 0
2012-05-07protein level
1 23 0
2012-04-10protein level
1 23 0
2012-01-13protein level
1 9 0
2011-12-20protein level
1 9 0
2011-11-11protein level
1 9 0
2011-08-23protein level
1 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
21 0 1 51166.5747
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-9679045,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
2 EBI-9679045,EBI-722504 KHDRBS3  
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.RNA binding
3 EBI-9679045,EBI-748961 CCNDBP1  
  .regulation of cell cycle
.cell cycle
.N/A .cytoplasm
4 EBI-9679045,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
  + 6 more...
5 EBI-9679045,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
6 EBI-9679045,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
7 EBI-9679045,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
8 EBI-9679045,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.Golgi membrane
9 EBI-9679045,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
10 EBI-9679045,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
11 EBI-9679045,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
12 EBI-9679045,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.transcription factor complex
  + 2 more...
13 EBI-9679045,EBI-6509505 INCA1  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
14 EBI-9679045,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
15 EBI-9679045,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
16 EBI-9679045,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
  + 2 more...
17 EBI-9679045,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
18 EBI-9679045,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
19 EBI-9679045,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
20 EBI-9679045,EBI-1380492 UBASH3B  
  .negative regulation of platelet aggregation
.regulation of release of sequestered calcium ion into cytosol
.negative regulation of protein kinase activity
.protein tyrosine phosphatase activity .cytoplasm
21 EBI-9679045,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
22 EBI-9679045,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
23 EBI-9679045,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
Health State
kidney tumor58
Developmental Stage
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
adipose tissue1.1
lymph node1.9
thyroid gland7
TumorNumber of patients and Staining levels
breast cancer
cervical cancer
colorectal cancer
endometrial cancer
head and neck cancer
liver cancer
lung cancer
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
No.Disease DescriptionRef.
1(*614754, gene) Doublesex- and mab3-related transcription factor 3; DMRT3OMIM

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