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> Protein (NX_Q9NQR1)
Protein (NX_Q9NQR1)
Protein
Gene SymbolSETD8 to neXtProt (NX_Q9NQR1)
DescriptionN-lysine methyltransferase SETD8
Chromosome12
Location12q24.31 (123868320 ~ 123893905) to Ensembl
Sequene Features : Isoforms 2, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.negative regulation of transcription, DNA-templated
.regulation of DNA damage response, signal transduction by p53 class mediator
  + 7 more...
.histone-lysine N-methyltransferase activity
.protein-lysine N-methyltransferase activity
.transcription corepressor activity
.p53 binding
.nucleolus
.chromosome
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 45 5
2014-09-19protein level
2 30 5
2014-05-27protein level
2 30 4
2014-02-25protein level
2 29 4
2013-12-09protein level
2 22 4
2013-11-01protein level
2 21 4
2013-09-12protein level
2 21 4
2013-08-17protein level
2 21 4
2013-07-15protein level
2 14 2
2013-06-11protein level
2 14 2
2013-02-12protein level
2 7 2
2012-12-20protein level
2 7 2
2012-10-30protein level
2 8 2
2012-10-07protein level
2 8 1
2012-08-24protein level
2 8 1
2012-07-28protein level
2 8 1
2012-06-08protein level
2 16 1
2012-05-07protein level
2 16 1
2012-04-10protein level
2 16 1
2012-01-13protein level
2 16 1
2011-12-20protein level
2 16 1
2011-11-11protein level
2 16 1
2011-08-23protein level
2 16 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NQR1-1
2 16 0 42862.8964
NX_Q9NQR1-2
1 16 0 39197.995
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1268946,EBI-302023 HIST2H4A  
  .protein heterotetramerization
.negative regulation of gene expression, epigenetic
.negative regulation of megakaryocyte differentiation
  + 13 more...
.poly(A) RNA binding
.histone binding
.histone demethylase activity (H4-K20 specific)
.DNA binding
.extracellular exosome
.protein complex
.membrane
  + 5 more...
2 EBI-1268946,EBI-1797287 TWIST1  
  .positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
.cell proliferation involved in heart valve development
.negative regulation of double-strand break repair
  + 51 more...
.E-box binding
.bHLH transcription factor binding
.transcription factor binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites50
bladder33
blood40
bone181
brain9
cervix144
connective tissue60
ear124
embryonic tissue9
eye33
heart33
intestine81
kidney42
larynx3664
liver24
lung92
lymph158
lymph node77
mammary gland19
Health State
TissuesTPM*
normal35
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor86
chondrosarcoma193
colorectal tumor106
gastrointestinal tumor75
germ cell tumor30
glioma18
head and neck tumor672
kidney tumor14
leukemia63
liver tumor10
lung tumor9
lymphoma96
non-neoplasia10
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS31
prostate cancer48
retinoblastoma64
skin tumor47
soft tissue/muscle tissue tumor47
uterine tumor44
Developmental Stage
TissuesTPM*
adult96
embryoid body14
fetus73
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.8
adrenal gland9.7
appendix14.3
bone marrow30
cerebral cortex10.7
colon15
duodenum11.7
esophagus31.9
gallbladder12.7
heart muscle10.2
kidney9.1
liver6.9
lung15
lymph node14.1
ovary9
pancreas8
placenta15.3
prostate32.6
salivary gland18
skin20.4
small intestine13.5
spleen14.6
stomach13.7
testis9.1
thyroid gland23.5
urinary bladder15.4
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*607240, gene) Set domain-containing protein 8; SETD8OMIM


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