Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q9NQT4)
Protein (NX_Q9NQT4)
Protein
Gene SymbolEXOSC5 to neXtProt (NX_Q9NQT4)
DescriptionExosome complex component RRP46
Chromosome19
Location19q13.2 (41892279 ~ 41903384) to Ensembl
Sequene Features : Isoforms 1, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA phosphodiester bond hydrolysis, exonucleolytic
.polyadenylation-dependent snoRNA 3'-end processing
.nuclear mRNA surveillance
  + 10 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 36 1
2014-09-19protein level
1 31 1
2014-05-27protein level
1 31 1
2014-02-25protein level
1 31 1
2013-12-09protein level
1 20 1
2013-11-01protein level
1 20 1
2013-09-12protein level
1 20 2
2013-08-17protein level
1 20 2
2013-07-15protein level
1 14 2
2013-06-11protein level
1 14 2
2013-02-12protein level
1 7 3
2012-12-20protein level
1 7 2
2012-10-30protein level
1 9 2
2012-10-07protein level
1 9 2
2012-08-24protein level
1 9 2
2012-07-28protein level
1 9 2
2012-06-08protein level
1 9 2
2012-05-07protein level
1 9 2
2012-04-10protein level
1 9 2
2012-01-13protein level
1 5 2
2011-12-20protein level
1 5 2
2011-11-11protein level
1 5 2
2011-08-23protein level
1 5 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NQT4-1
10 0 0 25232.8187
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-371876,EBI-719823 FCHO1  
  .clathrin-mediated endocytosis
.clathrin coat assembly
.AP-2 adaptor complex binding .coated pit
.plasma membrane
2 EBI-371876,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
3 EBI-371876,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
4 EBI-371876,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
5 EBI-371876,EBI-514538 BIRC2  
  .regulation of reactive oxygen species metabolic process
.regulation of cysteine-type endopeptidase activity
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
  + 40 more...
.protein N-terminus binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 3 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
6 EBI-371876,EBI-2505861 TNFAIP1  
  .protein homooligomerization
.positive regulation of DNA replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 8 more...
.GTP-Rho binding .Cul3-RING ubiquitin ligase complex
.endosome
.cytoplasm
.nucleolus
7 EBI-371876,EBI-10174653 DOCK8  
  .negative regulation of T cell apoptotic process
.memory T cell proliferation
.dendritic cell migration
  + 3 more...
.guanyl-nucleotide exchange factor activity .cell leading edge
.membrane
.cytosol
8 EBI-371876,EBI-371922 EXOSC8  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.AU-rich element binding .cytosol
.cytoplasm
.nucleolus
  + 2 more...
9 EBI-371876,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
10 EBI-371876,EBI-371866 EXOSC3  
  .polyadenylation-dependent snoRNA 3'-end processing
.nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription
.nuclear polyadenylation-dependent tRNA catabolic process
  + 12 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
11 EBI-371876,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
12 EBI-371876,EBI-371892 EXOSC1  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA binding .cytosol
.cytoplasm
.nucleolus
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites100
blood24
bone69
bone marrow20
brain16
cervix103
connective tissue20
embryonic tissue9
eye71
heart22
intestine94
larynx42
liver9
lung86
lymph135
lymph node44
mammary gland39
muscle37
ovary9
pancreas42
parathyroid48
pharynx24
placenta42
prostate5
skin52
testis4
thymus12
tonsil117
uterus34
Health State
TissuesTPM*
normal26
adrenal tumor158
breast (mammary gland) tumor21
cervical tumor144
chondrosarcoma84
colorectal tumor62
gastrointestinal tumor33
germ cell tumor37
glioma55
head and neck tumor7
leukemia31
liver tumor20
lung tumor184
lymphoma180
non-neoplasia20
pancreatic tumor47
primitive neuroectodermal tumor of the CNS39
prostate cancer9
retinoblastoma236
skin tumor79
soft tissue/muscle tissue tumor31
uterine tumor55
Developmental Stage
TissuesTPM*
adult33
embryoid body14
fetus39
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.3
adrenal gland11.7
appendix11.4
bone marrow9.1
cerebral cortex9.9
colon10.5
duodenum8.4
esophagus13.1
gallbladder5.6
heart muscle9.7
kidney9.5
liver7.8
lung5.6
lymph node17
ovary11.4
pancreas10.5
placenta6.7
prostate8.1
salivary gland10.3
skin14.1
small intestine7.4
spleen11.7
stomach10.5
testis8.6
thyroid gland10.8
urinary bladder12.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606492, gene) Exosome component 5; EXOSC5OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center