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> Protein (NX_Q9NQT5)
Protein (NX_Q9NQT5)
Protein
Gene SymbolEXOSC3 to neXtProt (NX_Q9NQT5)
DescriptionExosome complex component RRP40
Chromosome9
Location9p13.2 (37766975 ~ 37801434) to Ensembl
Sequene Features : Isoforms 2, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.polyadenylation-dependent snoRNA 3'-end processing
.nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription
.nuclear polyadenylation-dependent tRNA catabolic process
  + 12 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 25 2
2014-09-19protein level
2 23 2
2014-05-27protein level
2 23 2
2014-02-25protein level
2 23 2
2013-12-09protein level
2 19 2
2013-11-01protein level
2 19 1
2013-09-12protein level
2 19 1
2013-08-17protein level
2 19 1
2013-07-15protein level
2 17 1
2013-06-11protein level
2 17 1
2013-02-12protein level
2 14 2
2012-12-20protein level
2 14 2
2012-10-30protein level
2 16 2
2012-10-07protein level
2 16 1
2012-08-24protein level
2 12 1
2012-07-28protein level
2 13 1
2012-06-08protein level
2 15 1
2012-05-07protein level
2 15 1
2012-04-10protein level
1 15 1
2012-01-13protein level
1 6 1
2011-12-20protein level
1 6 1
2011-11-11protein level
1 6 1
2011-08-23protein level
1 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NQT5-1
6 6 0 29553.2841
NX_Q9NQT5-2
1 6 0 17236.967
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-371866,EBI-301735 EXOSC2  
  .polyadenylation-dependent snoRNA 3'-end processing
.nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription
.nuclear polyadenylation-dependent tRNA catabolic process
  + 10 more...
.7S RNA binding
.3'-5'-exoribonuclease activity
.cytosol
.cytoplasm
.nucleolus
  + 4 more...
2 EBI-371866,EBI-3672244 DIS3L  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.rRNA catabolic process
.mRNA catabolic process
.rRNA processing
.enzyme binding
.RNA binding
.3'-5'-exoribonuclease activity
.plasma membrane
.centrosome
.cytoplasm
  + 2 more...
3 EBI-371866,EBI-371922 EXOSC8  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.AU-rich element binding .cytosol
.cytoplasm
.nucleolus
  + 2 more...
4 EBI-371866,EBI-371823 EXOSC4  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.polyadenylation-dependent snoRNA 3'-end processing
.histone mRNA catabolic process
  + 14 more...
.AU-rich element binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
5 EBI-371866,EBI-371876 EXOSC5  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.polyadenylation-dependent snoRNA 3'-end processing
.nuclear mRNA surveillance
  + 10 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
6 EBI-371866,EBI-373539 DIS3  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.nucleic acid phosphodiester bond hydrolysis
.CUT catabolic process
  + 7 more...
.guanyl-nucleotide exchange factor activity
.endonuclease activity
.RNA binding
.3'-5'-exoribonuclease activity
.membrane
.cytosol
.nucleoplasm
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites50
bone97
bone marrow20
brain19
cervix20
connective tissue26
embryonic tissue14
eye62
heart33
intestine47
kidney42
liver14
lung38
lymph67
lymph node155
mammary gland59
muscle18
nerve64
ovary118
pancreas28
parathyroid97
placenta14
prostate10
salivary gland49
skin18
stomach31
testis55
thymus37
trachea19
uterus25
vascular19
Health State
TissuesTPM*
normal27
adrenal tumor158
chondrosarcoma96
colorectal tumor26
gastrointestinal tumor42
germ cell tumor56
glioma55
kidney tumor14
leukemia31
liver tumor31
lung tumor9
lymphoma41
non-neoplasia31
ovarian tumor118
pancreatic tumor47
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor39
uterine tumor11
Developmental Stage
TissuesTPM*
adult29
embryoid body14
blastocyst32
fetus23
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.4
adrenal gland14.2
appendix16.5
bone marrow7.3
cerebral cortex9.3
colon12
duodenum9.5
esophagus11.7
gallbladder9.2
heart muscle5.9
kidney11
liver9.7
lung8.8
lymph node23.6
ovary9.1
pancreas3.7
placenta10.4
prostate12
salivary gland6.1
skin7.9
small intestine11.7
spleen13
stomach13
testis26.5
thyroid gland9.9
urinary bladder10.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleLow
skin 1High
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606489, gene) Exosome component 3; EXOSC3OMIM
2(#614678, phenotype) Pontocerebellar hypoplasia, type 1b; PCH1BOMIM


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