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> Protein (NX_Q9NQX1)
Protein (NX_Q9NQX1)
Protein
Gene SymbolPRDM5 to neXtProt (NX_Q9NQX1)
DescriptionPR domain zinc finger protein 5
Chromosome4
Location4q27 (121606074 ~ 121844025) to Ensembl
Sequene Features : Isoforms 4, Variants 105, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H3-K9 methylation
.negative regulation of transcription, DNA-templated
.histone deacetylation
  + 2 more...
.repressing transcription factor binding
.metal ion binding
.transcription regulatory region DNA binding
  + 4 more...
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 105 0
2014-09-19protein level
4 70 0
2014-05-27protein level
4 69 0
2014-02-25protein level
3 64 0
2013-12-09protein level
3 55 0
2013-11-01protein level
3 52 0
2013-09-12protein level
3 52 0
2013-08-17protein level
3 52 0
2013-07-15protein level
3 34 0
2013-06-11protein level
3 34 0
2013-02-12protein level
3 15 0
2012-12-20protein level
3 14 0
2012-10-30protein level
3 19 0
2012-10-07protein level
3 19 0
2012-08-24protein level
3 14 0
2012-07-28protein level
3 14 0
2012-06-08protein level
3 15 0
2012-05-07protein level
3 15 0
2012-04-10protein level
3 15 0
2012-01-13protein level
3 4 0
2011-12-20protein level
3 4 0
2011-11-11protein level
3 4 0
2011-08-23protein level
3 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NQX1-1
2 29 0 73042.7681
NX_Q9NQX1-2
0 30 0 69816.3077
NX_Q9NQX1-3
2 6 0 12865.3951
NX_Q9NQX1-4
2 26 0 58086.7634
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-4292031,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
2 EBI-4292031,EBI-744366 EHMT2  
  .histone H3-K27 methylation
.histone H3-K9 methylation
.histone lysine methylation
  + 6 more...
.C2H2 zinc finger domain binding
.histone methyltransferase activity (H3-K27 specific)
.histone methyltransferase activity (H3-K9 specific)
  + 4 more...
.intermediate filament cytoskeleton
.intracellular membrane-bounded organelle
.nucleoplasm
  + 2 more...
3 EBI-4292031,EBI-949368 GFI1  
  .cellular response to lipopolysaccharide
.positive regulation of interleukin-6-mediated signaling pathway
.negative regulation of transcription, DNA-templated
  + 15 more...
.transcription regulatory region DNA binding
.zinc ion binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.transcriptional repressor complex
.nuclear body
.nuclear matrix
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
brain8
embryonic tissue4
eye9
larynx127
liver9
lung14
mouth60
muscle18
nerve128
pancreas9
prostate10
testis16
trachea38
uterus17
vascular19
Health State
TissuesTPM*
normal11
germ cell tumor11
glioma18
head and neck tumor37
pancreatic tumor9
Developmental Stage
TissuesTPM*
adult8
fetus14
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.1
adrenal gland5.8
appendix2.6
bone marrow3
cerebral cortex3.8
colon4.1
duodenum2.1
esophagus3.8
gallbladder3.9
heart muscle4.4
kidney3.1
lung6.6
lymph node1.1
ovary14.7
pancreas4.4
placenta3.5
prostate5.7
salivary gland1.2
skin1.5
small intestine1.8
spleen2.6
stomach3.5
testis6.6
thyroid gland9
urinary bladder3
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2High
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614161, gene) Pr domain-containing protein 5; PRDM5OMIM
2(#614170, phenotype) Brittle cornea syndrome 2; BCS2OMIM


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