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> Protein (NX_Q9NRA8)
Protein (NX_Q9NRA8)
Protein
Gene SymbolEIF4ENIF1 to neXtProt (NX_Q9NRA8)
DescriptionEukaryotic translation initiation factor 4E transporter
Chromosome22
Location22q12.2 (31832963 ~ 31892094) to Ensembl
Sequene Features : Isoforms 3, Variants 98, PTMs 24 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .poly(A) RNA binding
.protein transporter activity
.intracellular membrane-bounded organelle
.nuclear speck
.PML body
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 98 24
2014-09-19protein level
3 78 24
2014-05-27protein level
3 78 24
2014-02-25protein level
3 78 24
2013-12-09protein level
3 61 24
2013-11-01protein level
3 58 24
2013-09-12protein level
3 58 25
2013-08-17protein level
3 58 25
2013-07-15protein level
2 41 24
2013-06-11protein level
2 41 24
2013-02-12protein level
2 17 39
2012-12-20protein level
2 19 39
2012-10-30protein level
2 23 39
2012-10-07protein level
2 23 21
2012-08-24protein level
2 14 21
2012-07-28protein level
2 13 21
2012-06-08protein level
2 18 21
2012-05-07protein level
2 18 21
2012-04-10protein level
2 18 21
2012-01-13protein level
2 11 21
2011-12-20protein level
2 11 21
2011-11-11protein level
2 11 17
2011-08-23protein level
2 11 17
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NRA8-1
1 36 0 108133.9438
NX_Q9NRA8-2
1 32 0 88170.7741
NX_Q9NRA8-3
0 37 0 108262.002
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-301024,EBI-536879 OIP5  
  .cell division
.CENP-A containing nucleosome assembly
.cell communication
  + 2 more...
.N/A .Cajal body
.chromocenter
.cytoplasm
  + 4 more...
2 EBI-301024,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
3 EBI-301024,EBI-73440 EIF4E  
  .positive regulation of mitotic cell cycle
.cellular protein metabolic process
.lung development
  + 11 more...
.poly(A) RNA binding
.translation initiation factor activity
.RNA cap binding
.extracellular exosome
.chromatoid body
.RISC complex
  + 6 more...
4 EBI-301024,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
5 EBI-301024,EBI-351257 DDX6  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.cytoplasmic mRNA processing body assembly
.viral RNA genome packaging
  + 4 more...
.poly(A) RNA binding
.protein domain specific binding
.ATP binding
  + 3 more...
.intracellular membrane-bounded organelle
.RISC complex
.membrane
  + 5 more...
6 EBI-301024,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
7 EBI-301024,EBI-352986 HNRNPF  
  .regulation of RNA splicing
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding
.single-stranded RNA binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.membrane
.nucleoplasm
.nucleus
8 EBI-301024,EBI-743105 EFHC1  
  .cerebral cortex cell migration .protein C-terminus binding
.calcium ion binding
.mitotic spindle
.neuronal cell body
.axoneme
.centrosome
9 EBI-301024,EBI-948354 TTC19  
  .mitochondrial respiratory chain complex III assembly
.cytokinesis
.N/A .midbody
.centrosome
.mitochondrial inner membrane
.mitochondrion
10 EBI-301024,EBI-740376 DTX2  
  .protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.nuclear membrane
.cytoplasm
.nucleoplasm
11 EBI-301024,EBI-745369 DEF6  
  .N/A .N/A .membrane
.cell-cell junction
.plasma membrane
  + 2 more...
12 EBI-301024,EBI-2339898 FANCL  
  .regulation of cell proliferation
.gamete generation
.cellular response to DNA damage stimulus
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.Fanconi anaemia nuclear complex
.cytoplasm
.nucleoplasm
.nuclear envelope
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites25
bone27
brain43
connective tissue6
embryonic tissue56
eye47
heart22
intestine25
kidney18
liver14
lung26
lymph node22
mammary gland59
mouth45
muscle37
nerve64
ovary39
pancreas9
pharynx49
placenta17
prostate36
skin71
spleen18
testis101
thymus12
thyroid21
trachea57
uterus68
Health State
TissuesTPM*
normal56
adrenal tumor158
breast (mammary gland) tumor10
chondrosarcoma36
colorectal tumor44
gastrointestinal tumor16
germ cell tumor56
glioma27
head and neck tumor22
kidney tumor29
leukemia31
liver tumor31
lung tumor9
lymphoma69
non-neoplasia31
ovarian tumor26
primitive neuroectodermal tumor of the CNS15
prostate cancer19
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor88
Developmental Stage
TissuesTPM*
adult42
embryoid body85
blastocyst16
fetus84
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10
adrenal gland13
appendix11.4
bone marrow10.2
cerebral cortex16.8
colon11.7
duodenum9.7
esophagus12.2
gallbladder10.8
heart muscle11.7
kidney12.7
liver4.9
lung11.5
lymph node14.9
ovary19.1
pancreas5.1
placenta13.5
prostate12.3
salivary gland9.5
skin12.2
small intestine9.6
spleen13.7
stomach11.3
testis48.8
thyroid gland15.3
urinary bladder12.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2High
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607445, gene) Eukaryotic translation initiation factor 4e nuclear import factorOMIM


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