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> Protein (NX_Q9NRI5)
Protein (NX_Q9NRI5)
Protein
Gene SymbolDISC1 to neXtProt (NX_Q9NRI5)
DescriptionDisrupted in schizophrenia 1 protein
Chromosome1
Location1q42.2 (231762561 ~ 232177018) to Ensembl
Sequene Features : Isoforms 11, Variants 144, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of synapse maturation
.canonical Wnt signaling pathway
  + 10 more...
.N/A .postsynaptic membrane
.ciliary basal body
.cell junction
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
11 144 0
2014-09-19protein level
11 117 0
2014-05-27protein level
11 115 0
2014-02-25protein level
11 114 0
2013-12-09protein level
11 89 0
2013-11-01protein level
11 86 0
2013-09-12protein level
11 86 0
2013-08-17protein level
11 86 0
2013-07-15protein level
8 64 0
2013-06-11protein level
8 64 0
2013-02-12protein level
8 42 0
2012-12-20protein level
8 40 0
2012-10-30protein level
8 50 0
2012-10-07protein level
8 50 0
2012-08-24protein level
8 49 0
2012-07-28protein level
8 49 0
2012-06-08protein level
8 52 0
2012-05-07protein level
8 44 0
2012-04-10protein level
4 39 0
2012-01-13protein level
4 24 0
2011-12-20protein level
4 24 0
2011-11-11protein level
4 24 0
2011-08-23protein level
4 24 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NRI5-1
2 36 0 93551.7289
NX_Q9NRI5-10
0 15 0 37168.8143
NX_Q9NRI5-11
1 9 0 22184.3814
NX_Q9NRI5-2
1 36 0 91066.4935
NX_Q9NRI5-3
2 28 0 73869.7494
NX_Q9NRI5-4
1 15 0 38560.4869
NX_Q9NRI5-5
5 28 0 82209.7994
NX_Q9NRI5-6
0 25 0 62478.0461
NX_Q9NRI5-7
1 25 0 60227.5884
NX_Q9NRI5-8
1 28 0 75486.6848
NX_Q9NRI5-9
1 28 0 71967.9289
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-529989,EBI-709735 EIF3H  
  .cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 3 more...
.poly(A) RNA binding
.translation initiation factor activity
.eukaryotic translation initiation factor 3 complex, eIF3m
.extracellular exosome
.eukaryotic 48S preinitiation complex
  + 4 more...
2 EBI-529989,EBI-718519 TRIO  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.neurotrophin TRK receptor signaling pathway
  + 5 more...
.ATP binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.protein serine/threonine kinase activity
.cytosol
3 EBI-529989,EBI-530012 PCNT  
  .positive regulation of intracellular protein transport
.neural precursor cell proliferation
.brain morphogenesis
  + 13 more...
.N/A .intercellular bridge
.ciliary basal body
.centriolar satellite
  + 8 more...
4 EBI-529989,EBI-1104674 CLU  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of neurofibrillary tangle assembly
  + 34 more...
.misfolded protein binding
.chaperone binding
.ubiquitin protein ligase binding
.apical dendrite
.neurofibrillary tangle
.blood microparticle
  + 15 more...
5 EBI-529989,EBI-928749 COL6A2  
  .protein heterotrimerization
.collagen catabolic process
.extracellular matrix organization
  + 4 more...
.N/A .extracellular exosome
.protein complex
.sarcolemma
  + 7 more...
6 EBI-529989,EBI-492498 ATF4  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of oxidative stress-induced neuron death
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  + 21 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 9 more...
.CHOP-ATF4 complex
.ATF1-ATF4 transcription factor complex
.ATF4-CREB1 transcription factor complex
  + 8 more...
7 EBI-529989,EBI-77797 ACTN2  
  .negative regulation of protein localization to cell surface
.positive regulation of potassium ion transmembrane transporter activity
.negative regulation of potassium ion transmembrane transporter activity
  + 13 more...
.titin Z domain binding
.FATZ binding
.protein dimerization activity
  + 8 more...
.extracellular exosome
.dendritic spine
.pseudopodium
  + 9 more...
8 EBI-529989,EBI-929047 MAP1A  
  .activation of mitophagy in response to mitochondrial depolarization
.sensory perception of sound
.positive regulation of defense response to virus by host
.microtubule cytoskeleton organization
.structural molecule activity .microtubule associated complex
.microtubule
.cytosol
9 EBI-529989,EBI-351561 SPTBN1  
  .positive regulation of protein localization to plasma membrane
.regulation of protein localization to plasma membrane
.positive regulation of interleukin-2 secretion
  + 9 more...
.GTPase binding
.poly(A) RNA binding
.ankyrin binding
  + 3 more...
.extracellular exosome
.protein complex
.cuticular plate
  + 7 more...
10 EBI-529989,EBI-310758 DST  
  .cell motility
.intermediate filament cytoskeleton organization
.hemidesmosome assembly
  + 8 more...
.microtubule plus-end binding
.protein homodimerization activity
.protein C-terminus binding
  + 2 more...
.extracellular exosome
.intermediate filament cytoskeleton
.microtubule plus-end
  + 19 more...
11 EBI-529989,EBI-715074 DCTN2  
  .melanosome transport
.antigen processing and presentation of exogenous peptide antigen via MHC class II
.cell proliferation
  + 5 more...
.spectrin binding
.motor activity
.extracellular exosome
.vesicle
.growth cone
  + 8 more...
12 EBI-529989,EBI-356015 DYNC1H1  
  .establishment of spindle localization
.stress granule assembly
.cytoplasmic mRNA processing body assembly
  + 7 more...
.poly(A) RNA binding
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.filopodium
.membrane
  + 4 more...
13 EBI-529989,EBI-602041 ITSN1  
  .apoptotic signaling pathway
.positive regulation of protein kinase B signaling
.regulation of small GTPase mediated signal transduction
  + 8 more...
.proline-rich region binding
.protein complex scaffold
.kinase activator activity
  + 3 more...
.synapse
.neuron projection
.endocytic vesicle
  + 5 more...
14 EBI-529989,EBI-928732 ATF7IP  
  .regulation of RNA polymerase II transcriptional preinitiation complex assembly
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 5 more...
.ATPase activity
.transcription corepressor activity
.cytoplasm
.transcription factor complex
.nucleoplasm
.nucleus
15 EBI-529989,EBI-928795 CCDC141  
  .centrosome localization
.cerebral cortex radially oriented cell migration
.N/A .centrosome
.cytoplasm
16 EBI-529989,EBI-1785446 ANKHD1  
  .N/A .poly(A) RNA binding .cytoplasm
17 EBI-529989,EBI-928867 SYNE1  
  .nuclear matrix anchoring at nuclear membrane
.cytoskeletal anchoring at nuclear membrane
.muscle cell differentiation
  + 3 more...
.actin filament binding
.poly(A) RNA binding
.protein homodimerization activity
  + 2 more...
.postsynaptic membrane
.LINC complex
.nuclear membrane
  + 9 more...
18 EBI-529989,EBI-928811 TRAF3IP1  
  .negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.negative regulation of defense response to virus
.embryonic digit morphogenesis
  + 11 more...
.N/A .ciliary tip
.primary cilium
.ciliary basal body
  + 4 more...
19 EBI-529989,EBI-741977 CEP63  
  .cell division
.spindle assembly
.signal transduction in response to DNA damage
  + 6 more...
.N/A .cytosol
.centriole
.centrosome
.spindle pole
20 EBI-529989,EBI-636085 RANBP9  
  .negative regulation of ERK1 and ERK2 cascade
.axon guidance
.microtubule nucleation
.protein complex assembly
.enzyme binding
.Ran GTPase binding
.microtubule associated complex
.cytosol
.nucleus
21 EBI-529989,EBI-1105073 OLFM1  
  .negative regulation of neuron migration
.negative regulation of beta-amyloid formation
.cardiac epithelial to mesenchymal transition
  + 6 more...
.beta-amyloid binding .synapse
.alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
.cell junction
  + 2 more...
22 EBI-529989,EBI-928842 NDEL1  
  .neuron projection extension
.neurofilament cytoskeleton organization
.centrosome localization
  + 20 more...
.oligopeptidase activity
.microtubule binding
.neurofilament cytoskeleton
.axon hillock
.cell leading edge
  + 10 more...
23 EBI-529989,EBI-308543 SPTBN4  
  .establishment of protein localization to plasma membrane
.cardiac conduction
.actin filament capping
  + 14 more...
.spectrin binding
.ankyrin binding
.phosphatase binding
  + 3 more...
.cell body fiber
.extracellular exosome
.axon hillock
  + 12 more...
24 EBI-529989,EBI-522925 MACF1  
  .regulation of focal adhesion assembly
.positive regulation of axon extension
.Golgi to plasma membrane protein transport
  + 10 more...
.actin filament binding
.poly(A) RNA binding
.ATPase activity
  + 2 more...
.ruffle membrane
.actin cytoskeleton
.plasma membrane
  + 4 more...
25 EBI-529989,EBI-492509 ATF5  
  .negative regulation of nucleic acid-templated transcription
.negative regulation of astrocyte differentiation
.positive regulation of transcription from RNA polymerase II promoter
  + 6 more...
.transcription corepressor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.transcription factor complex
.nucleoplasm
26 EBI-529989,EBI-1104844 KIF3A  
  .plus-end-directed vesicle transport along microtubule
.membrane organization
.cilium morphogenesis
  + 7 more...
.spectrin binding
.ATPase activity
.ATP-dependent microtubule motor activity, plus-end-directed
  + 2 more...
.ciliary tip
.primary cilium
.extracellular exosome
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites50
bladder66
blood49
bone13
bone marrow41
brain60
connective tissue26
ear62
embryonic tissue79
esophagus49
eye86
heart78
intestine43
kidney33
liver92
lung29
mammary gland26
mouth30
muscle47
nerve64
ovary29
pancreas18
pharynx147
placenta49
prostate26
salivary gland49
skin23
spleen37
stomach41
testis62
thymus12
thyroid42
trachea19
umbilical cord145
uterus47
vascular38
Health State
TissuesTPM*
normal53
bladder carcinoma56
breast (mammary gland) tumor21
colorectal tumor35
esophageal tumor57
gastrointestinal tumor59
germ cell tumor45
glioma46
head and neck tumor14
kidney tumor29
leukemia31
liver tumor124
lung tumor19
non-neoplasia51
ovarian tumor39
pancreatic tumor9
primitive neuroectodermal tumor of the CNS141
prostate cancer19
retinoblastoma64
skin tumor31
soft tissue/muscle tissue tumor47
uterine tumor33
Developmental Stage
TissuesTPM*
adult39
embryoid body128
blastocyst48
neonate64
fetus32
infant297
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.7
adrenal gland1.8
appendix4.2
bone marrow2.4
cerebral cortex3.5
colon1.5
esophagus1.6
gallbladder4.1
heart muscle2.1
lung1.9
lymph node2.6
ovary4.7
placenta6.5
prostate1.2
salivary gland1.5
small intestine1
spleen2.9
stomach1.1
testis1
thyroid gland2.8
urinary bladder3.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#181500, phenotype) Schizophrenia; SCZDOMIM
2(#604906, phenotype) Schizophrenia 9; SCZD9OMIM
3(*605210, gene) Disrupted in schizophrenia 1; DISC1OMIM


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