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> Protein (NX_Q9NRP7)
Protein (NX_Q9NRP7)
Protein
Gene SymbolSTK36 to neXtProt (NX_Q9NRP7)
DescriptionSerine/threonine-protein kinase 36
Chromosome2
Location2q35 (219536749 ~ 219567439) to Ensembl
Sequene Features : Isoforms 2, Variants 187, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of smoothened signaling pathway
.cilium assembly
  + 5 more...
.transcription factor binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 187 0
2014-09-19protein level
2 153 0
2014-05-27protein level
2 153 0
2014-02-25protein level
2 153 0
2013-12-09protein level
2 119 0
2013-11-01protein level
2 116 0
2013-09-12protein level
2 116 0
2013-08-17protein level
2 116 0
2013-07-15protein level
2 90 0
2013-06-11protein level
2 90 0
2013-02-12protein level
2 58 0
2012-12-20protein level
2 57 0
2012-10-30protein level
2 68 0
2012-10-07protein level
2 68 0
2012-08-24protein level
2 65 0
2012-07-28protein level
2 65 0
2012-06-08protein level
2 70 0
2012-05-07protein level
2 59 0
2012-04-10protein level
2 59 0
2012-01-13protein level
2 33 0
2011-12-20protein level
2 33 0
2011-11-11protein level
2 33 0
2011-08-23protein level
2 33 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NRP7-1
2 53 1 143902.8096
NX_Q9NRP7-2
1 53 1 141646.582
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-863797,EBI-308084 GLI1  
  .negative regulation of canonical Wnt signaling pathway
.notochord regression
.digestive tract morphogenesis
  + 17 more...
.metal ion binding
.transcription regulatory region DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  + 2 more...
.ciliary base
.ciliary tip
.primary cilium
  + 5 more...
2 EBI-863797,EBI-308055 GLI3  
  .negative regulation of canonical Wnt signaling pathway
.thymocyte apoptotic process
.cell differentiation involved in kidney development
  + 58 more...
.metal ion binding
.histone deacetylase binding
.histone acetyltransferase binding
  + 5 more...
.ciliary base
.ciliary tip
.primary cilium
  + 7 more...
3 EBI-863797,EBI-740595 SUFU  
  .negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.negative regulation of smoothened signaling pathway
  + 15 more...
.protein kinase binding
.transcription factor binding
.signal transducer activity
.transcription corepressor activity
.ciliary base
.ciliary tip
.primary cilium
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood8
bone13
brain29
connective tissue20
embryonic tissue23
intestine30
kidney9
lung8
mammary gland6
mouth15
muscle18
placenta7
testis18
thyroid21
uterus12
Health State
TissuesTPM*
normal18
bladder carcinoma56
chondrosarcoma36
colorectal tumor35
gastrointestinal tumor16
germ cell tumor26
glioma18
head and neck tumor22
kidney tumor14
leukemia10
lymphoma27
ovarian tumor13
pancreatic tumor47
prostate cancer38
skin tumor39
soft tissue/muscle tissue tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult20
embryoid body28
blastocyst16
neonate96
fetus16
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.4
adrenal gland17.7
appendix13.5
bone marrow3.5
cerebral cortex15.3
colon9.3
duodenum10
esophagus9
gallbladder27
heart muscle6.8
kidney14.3
liver5.3
lung16.4
lymph node12.5
ovary27.1
pancreas9.6
placenta8.7
prostate23.6
salivary gland11.5
skin17.1
small intestine10.8
spleen12.1
stomach14.8
testis53.7
thyroid gland20.7
urinary bladder21.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607652, gene) Serine/threonine protein kinase 36; STK36OMIM


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