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> Protein (NX_Q9NS23)
Protein (NX_Q9NS23)
Protein
Gene SymbolRASSF1 to neXtProt (NX_Q9NS23)
DescriptionRas association domain-containing protein 1
Chromosome3
Location3p21.31 (50367219 ~ 50378411) to Ensembl
Sequene Features : Isoforms 8, Variants 53, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cell cycle arrest
.protein stabilization
.positive regulation of protein ubiquitination
  + 3 more...
.protein N-terminus binding
.identical protein binding
.zinc ion binding
.microtubule cytoskeleton
.plasma membrane
.microtubule
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 53 5
2014-09-19protein level
8 45 5
2014-05-27protein level
8 41 5
2014-02-25protein level
8 41 3
2013-12-09protein level
8 32 3
2013-11-01protein level
8 31 2
2013-09-12protein level
8 31 2
2013-08-17protein level
8 31 2
2013-07-15protein level
8 21 2
2013-06-11protein level
8 21 2
2013-02-12protein level
8 16 15
2012-12-20protein level
8 16 15
2012-10-30protein level
8 18 15
2012-10-07protein level
8 18 3
2012-08-24protein level
8 16 3
2012-07-28protein level
8 16 3
2012-06-08protein level
8 7 3
2012-05-07protein level
8 7 3
2012-04-10protein level
8 7 3
2012-01-13protein level
8 7 3
2011-12-20protein level
8 11 3
2011-11-11protein level
8 11 3
2011-08-23protein level
8 11 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NS23-1
0 16 0 39194.1978
NX_Q9NS23-2
0 17 0 38788.9767
NX_Q9NS23-3
0 9 0 21885.7168
NX_Q9NS23-4
0 12 0 31206.9291
NX_Q9NS23-5
1 16 0 39240.2548
NX_Q9NS23-6
0 3 0 9931.0607
NX_Q9NS23-7
3 3 0 16109.0487
NX_Q9NS23-9
0 2 0 8650.8703
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-367363,EBI-349968 SUV39H1  
  .cellular response to hypoxia
.rhythmic process
.negative regulation of transcription, DNA-templated
  + 15 more...
.protein N-terminus binding
.histone methyltransferase activity (H3-K9 specific)
.histone methyltransferase activity
  + 5 more...
.rDNA heterochromatin
.chromatin silencing complex
.nucleoplasm
  + 5 more...
2 EBI-367363,EBI-710124 KDM1A  
  .positive regulation of stem cell proliferation
.positive regulation of neural precursor cell proliferation
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 27 more...
.androgen receptor binding
.flavin adenine dinucleotide binding
.transcription regulatory region DNA binding
  + 13 more...
.transcription factor complex
.nucleoplasm
.nucleus
.nuclear chromatin
3 EBI-367363,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
4 EBI-438698,EBI-350145 HRAS  
  .positive regulation of miRNA metabolic process
.positive regulation of actin cytoskeleton reorganization
.positive regulation of ruffle assembly
  + 53 more...
.protein C-terminus binding
.GTP binding
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 4 more...
5 EBI-367363,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
6 EBI-367363,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
7 EBI-438698,EBI-739737 EWSR1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.identical protein binding
.zinc ion binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleolus
  + 2 more...
8 EBI-438698,EBI-367462 CDC20  
  .positive regulation of synapse maturation
.activation of anaphase-promoting complex activity
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 14 more...
.enzyme binding
.protein C-terminus binding
.perinuclear region of cytoplasm
.protein complex
.cytosol
  + 6 more...
9 EBI-438698,EBI-367376 STK4  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.protein homodimerization activity
  + 6 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
10 EBI-438698,EBI-992580 STK3  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.ATP binding
  + 4 more...
.cytosol
.cytoplasm
.nucleus
11 EBI-438698,EBI-1227043 E4F1  
  .mitotic cell cycle arrest
.cell division
.regulation of growth
  + 8 more...
.metal ion binding
.cAMP response element binding
.ligase activity
  + 6 more...
.spindle
.cytoplasm
.nucleoplasm
12 EBI-367363,EBI-2603996 MAP1LC3C  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
13 EBI-367363,EBI-373144 MAP1LC3B  
  .regulation of mitochondrion degradation
.membrane fusion
.nucleophagy
  + 3 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 9 more...
14 EBI-367363,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
blood89
bone41
bone marrow82
brain28
cervix144
connective tissue26
embryonic tissue28
esophagus99
eye43
heart11
intestine38
kidney28
liver19
lung32
lymph45
lymph node89
mammary gland19
mouth15
muscle18
ovary39
pancreas28
placenta74
prostate15
skin23
spleen187
stomach31
testis22
thymus75
uterus21
Health State
TissuesTPM*
normal35
adrenal tumor237
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma24
colorectal tumor44
esophageal tumor115
gastrointestinal tumor25
germ cell tumor18
glioma55
kidney tumor58
leukemia127
liver tumor20
lymphoma69
non-neoplasia20
ovarian tumor26
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
prostate cancer9
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor23
uterine tumor22
Developmental Stage
TissuesTPM*
adult39
embryoid body14
blastocyst48
fetus41
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.3
adrenal gland13.5
appendix25.3
bone marrow54
cerebral cortex7.4
colon15
duodenum14.8
esophagus16.4
gallbladder23.5
heart muscle15.2
kidney10.5
liver8.3
lung30
lymph node39.4
ovary12.7
pancreas15.5
placenta23
prostate15.6
salivary gland18
skin22.4
small intestine16.6
spleen43.6
stomach19.2
testis26.3
thyroid gland11.5
urinary bladder24.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605082, gene) Ras association domain family protein 1; RASSF1OMIM


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