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> Protein (NX_Q9NS37)
Protein (NX_Q9NS37)
Protein
Gene SymbolCREBZF to neXtProt (NX_Q9NS37)
DescriptionCREB/ATF bZIP transcription factor
Chromosome11
Location11q14.1 (85370752 ~ 85393951) to Ensembl
Sequene Features : Isoforms 1, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of sequence-specific DNA binding transcription factor activity
.negative regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 33 3
2014-09-19protein level
1 23 3
2014-05-27protein level
1 23 3
2014-02-25protein level
1 7 3
2013-12-09protein level
1 0 3
2013-11-01protein level
1 0 3
2013-09-12protein level
1 0 3
2013-08-17protein level
1 0 3
2013-07-15protein level
1 0 2
2013-06-11protein level
1 0 2
2013-02-12protein level
1 0 0
2012-12-20protein level
1 0 0
2012-10-30protein level
1 1 0
2012-10-07protein level
1 1 0
2012-08-24protein level
1 1 0
2012-07-28protein level
1 1 0
2012-06-08protein level
1 5 0
2012-05-07protein level
1 5 0
2012-04-10protein level
1 5 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NS37-1
16 0 0 37111.2253
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-632965,EBI-10198377 ACYP2  
  .phosphate-containing compound metabolic process .acylphosphatase activity .mitochondrion
2 EBI-632965,EBI-492498 ATF4  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of oxidative stress-induced neuron death
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  + 21 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 9 more...
.CHOP-ATF4 complex
.ATF1-ATF4 transcription factor complex
.ATF4-CREB1 transcription factor complex
  + 8 more...
3 EBI-632965,EBI-396176 HCFC1  
  .protein stabilization
.positive regulation of cell cycle
.histone H4-K16 acetylation
  + 12 more...
.identical protein binding
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.MLL1 complex
.MLL5-L complex
.Set1C/COMPASS complex
  + 7 more...
4 EBI-632965,EBI-6447954 TTC23  
  .N/A .N/A .N/A
5 EBI-632965,EBI-748128 CTNNBL1  
  .positive regulation of apoptotic process
.somatic diversification of immunoglobulins
.gene expression
  + 3 more...
.enzyme binding .membrane
.cytoplasm
.spliceosomal complex
  + 3 more...
6 EBI-632965,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
bladder66
blood57
bone55
bone marrow123
brain43
cervix61
connective tissue33
ear248
embryonic tissue159
esophagus99
eye90
heart167
intestine357
kidney99
larynx127
liver53
lung104
lymph node512
mammary gland72
mouth15
nerve193
ovary167
pancreas56
parathyroid97
placenta56
prostate89
skin18
stomach20
testis41
thymus62
thyroid21
trachea19
uterus103
vascular58
Health State
TissuesTPM*
normal95
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma72
colorectal tumor595
esophageal tumor115
gastrointestinal tumor16
germ cell tumor11
glioma46
head and neck tumor29
kidney tumor43
leukemia201
liver tumor20
lymphoma27
non-neoplasia103
ovarian tumor210
pancreatic tumor57
primitive neuroectodermal tumor of the CNS7
prostate cancer96
soft tissue/muscle tissue tumor63
uterine tumor122
Developmental Stage
TissuesTPM*
adult114
embryoid body157
blastocyst146
fetus127
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.5
adrenal gland38.3
appendix43.9
bone marrow16.4
cerebral cortex29.9
colon21.4
duodenum40.3
esophagus20.1
gallbladder34.2
heart muscle15.6
kidney23.6
liver11.9
lung36.3
lymph node55.4
ovary46.4
pancreas23.3
placenta30.8
prostate43.3
salivary gland27.8
skin33.5
small intestine39.7
spleen51.6
stomach31.3
testis23.4
thyroid gland33.5
urinary bladder26.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606444, gene) Zhangfei proteinOMIM


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