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> Protein (NX_Q9NS73)
Protein (NX_Q9NS73)
Protein
Gene SymbolMBIP to neXtProt (NX_Q9NS73)
DescriptionMAP3K12-binding inhibitory protein 1
Chromosome14
Location14q13.3 (36767770 ~ 36789882) to Ensembl
Sequene Features : Isoforms 4, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 36 3
2014-09-19protein level
4 21 3
2014-05-27protein level
4 21 3
2014-02-25protein level
4 21 3
2013-12-09protein level
4 17 3
2013-11-01protein level
4 17 2
2013-09-12protein level
4 17 2
2013-08-17protein level
4 17 2
2013-07-15protein level
4 13 1
2013-06-11protein level
4 13 1
2013-02-12protein level
4 7 8
2012-12-20protein level
4 7 8
2012-10-30protein level
4 8 8
2012-10-07protein level
4 8 2
2012-08-24protein level
4 6 2
2012-07-28protein level
4 6 2
2012-06-08protein level
4 3 2
2012-05-07protein level
4 3 2
2012-04-10protein level
4 3 2
2012-01-13protein level
4 3 2
2011-12-20protein level
4 8 2
2011-11-11protein level
4 8 2
2011-08-23protein level
4 6 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NS73-1
1 16 0 39257.1384
NX_Q9NS73-2
1 14 0 34002.3643
NX_Q9NS73-3
2 13 0 32203.3755
NX_Q9NS73-5
1 16 0 39129.0802
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10182361,EBI-1055079 POLR1C  
  .negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
2 EBI-10182361,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
3 EBI-10182361,EBI-395261 CCNC  
  .positive regulation of transcription from RNA polymerase II promoter
.gene expression
.Notch signaling pathway
  + 4 more...
.N/A .mediator complex
.nucleoplasm
4 EBI-10182361,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
5 EBI-10182361,EBI-355924 MCM7  
  .cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
6 EBI-10182361,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
7 EBI-741953,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
8 EBI-10182361,EBI-746389 RAP1GDS1  
  .positive regulation of mitochondrial calcium ion concentration
.positive regulation of GTPase activity
.negative regulation of endoplasmic reticulum calcium ion concentration
  + 2 more...
.GTPase activator activity .extracellular exosome
.cytosol
.endoplasmic reticulum
.mitochondrion
9 EBI-10182361,EBI-540834 WDR5  
  .histone H3-K4 methylation
.histone H4-K16 acetylation
.histone H4-K8 acetylation
  + 6 more...
.N/A .MLL1 complex
.Set1C/COMPASS complex
.histone methyltransferase complex
  + 4 more...
10 EBI-741953,EBI-745426 PPFIA1  
  .negative regulation of establishment of protein localization to plasma membrane
.negative regulation of stress fiber assembly
.glutamate secretion
  + 4 more...
.signal transducer activity .presynaptic active zone
.focal adhesion
.cytosol
.cytoplasm
11 EBI-10182361,EBI-10229433 BFSP2  
  .lens fiber cell development
.response to stimulus
.cell maturation
  + 2 more...
.structural constituent of eye lens
.structural constituent of cytoskeleton
.plasma membrane
.intermediate filament
.cytoplasm
12 EBI-10182361,EBI-10233719 DIP2A  
  .regulation of apoptotic process
.negative regulation of gene expression
.multicellular organismal development
.catalytic activity .cell surface
.nucleus
13 EBI-10182361,EBI-1643885 KLC3  
  .axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
14 EBI-10182361,EBI-8063723 TGIF2LY  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .nucleus
15 EBI-10182361,EBI-10262896 CCDC135  
  .N/A .N/A .motile cilium
.cytoskeleton
.cytoplasm
16 EBI-10182361,EBI-742102 EXOC8  
  .membrane organization
.exocyst localization
.cellular protein metabolic process
  + 5 more...
.Ral GTPase binding .growth cone
.membrane
.plasma membrane
  + 4 more...
17 EBI-10182361,EBI-488533 ING5  
  .positive regulation of apoptotic signaling pathway
.negative regulation of growth
.positive regulation of transcription, DNA-templated
  + 7 more...
.methylated histone binding
.zinc ion binding
.chromatin binding
.MOZ/MORF histone acetyltransferase complex
.nucleoplasm
.nucleus
18 EBI-10182361,EBI-739825 MOAP1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.apoptotic signaling pathway
.positive regulation of release of cytochrome c from mitochondria
  + 4 more...
.ubiquitin protein ligase binding .cytosol
.mitochondrial outer membrane
.mitochondrion
.cytoplasm
19 EBI-10182361,EBI-928842 NDEL1  
  .neuron projection extension
.neurofilament cytoskeleton organization
.centrosome localization
  + 20 more...
.oligopeptidase activity
.microtubule binding
.neurofilament cytoskeleton
.axon hillock
.cell leading edge
  + 10 more...
20 EBI-10182361,EBI-750907 CSRP2BP  
  .histone H3 acetylation
.chromatin organization
.G2/M transition of mitotic cell cycle
.LIM domain binding
.histone acetyltransferase activity
.cytoplasm
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
21 EBI-10182361,EBI-742388 PLEKHF2  
  .protein transport .metal ion binding .early endosome membrane
.transport vesicle
.endoplasmic reticulum
22 EBI-10182361,EBI-1104552 MIS18A  
  .positive regulation of protein targeting to mitochondrion
.cell division
.regulation of DNA methylation
  + 4 more...
.N/A .cytoplasm
.nucleoplasm
.nucleus
.chromosome, centromeric region
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder100
blood32
bone41
bone marrow143
brain32
cervix20
connective tissue20
ear62
embryonic tissue42
esophagus99
eye47
heart44
intestine25
kidney28
liver29
lung74
lymph node66
mammary gland6
mouth15
muscle28
ovary9
pancreas32
pharynx49
placenta14
prostate47
salivary gland49
skin4
stomach41
testis22
thyroid85
trachea38
uterus30
vascular116
Health State
TissuesTPM*
normal38
bladder carcinoma170
cervical tumor28
chondrosarcoma12
colorectal tumor35
esophageal tumor115
gastrointestinal tumor33
germ cell tumor18
glioma37
head and neck tumor22
kidney tumor29
leukemia105
liver tumor31
lung tumor19
non-neoplasia31
ovarian tumor13
pancreatic tumor38
primitive neuroectodermal tumor of the CNS55
prostate cancer48
retinoblastoma86
skin tumor7
soft tissue/muscle tissue tumor55
uterine tumor44
Developmental Stage
TissuesTPM*
adult32
embryoid body42
blastocyst48
fetus28
infant85
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.7
adrenal gland21.3
appendix10.8
bone marrow18.7
cerebral cortex18.6
colon15.7
duodenum14.6
esophagus15.8
gallbladder16
heart muscle10.4
kidney20.5
liver11
lung68.2
lymph node15.7
ovary28.5
pancreas8
placenta14.9
prostate17
salivary gland12.1
skin22.2
small intestine16.3
spleen13.8
stomach23.4
testis17.7
thyroid gland68
urinary bladder16.2
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowLow
breastLow
bronchusLow
cerebellumLow
cerebral cortexLow
cervix, uterineLow
duodenumLow
endometrium 1Low
epididymisLow
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyLow
lateral ventricleLow
lungLow
lymph nodeLow
pancreasMedium
placentaMedium
prostateMedium
rectumLow
seminal vesicleLow
skin 1Medium
small intestineLow
soft tissue 1Low
soft tissue 2Low
stomach 1Low
stomach 2Low
testisMedium
thyroid glandLow
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609431, gene) Map3k12-binding inhibitory protein; MBIPOMIM


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