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> Protein (NX_Q9NS91)
Protein (NX_Q9NS91)
Protein
Gene SymbolRAD18 to neXtProt (NX_Q9NS91)
DescriptionE3 ubiquitin-protein ligase RAD18
Chromosome3
Location3p25.3 (8817088 ~ 9005457) to Ensembl
Sequene Features : Isoforms 1, Variants 72, PTMs 23 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of DNA recombination
.DNA damage response, detection of DNA damage
.translesion synthesis
  + 5 more...
.ubiquitin protein ligase activity
.single-stranded DNA-dependent ATPase activity
.ubiquitin protein ligase binding
  + 5 more...
.Rad6-Rad18 complex
.replication fork
.nucleoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 72 23
2014-09-19protein level
1 59 23
2014-05-27protein level
1 59 23
2014-02-25protein level
1 59 23
2013-12-09protein level
1 43 24
2013-11-01protein level
1 42 19
2013-09-12protein level
1 42 18
2013-08-17protein level
1 42 18
2013-07-15protein level
1 24 9
2013-06-11protein level
1 24 9
2013-02-12protein level
1 14 12
2012-12-20protein level
1 14 12
2012-10-30protein level
1 21 12
2012-10-07protein level
1 21 12
2012-08-24protein level
1 18 12
2012-07-28protein level
1 18 12
2012-06-08protein level
1 20 12
2012-05-07protein level
1 20 12
2012-04-10protein level
1 20 12
2012-01-13protein level
1 6 12
2011-12-20protein level
1 6 12
2011-11-11protein level
1 6 12
2011-08-23protein level
1 6 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NS91-1
25 0 0 56187.1148
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2339393,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
bladder66
blood8
bone13
bone marrow123
brain11
cervix20
connective tissue13
embryonic tissue56
esophagus49
eye4
heart22
intestine43
kidney47
liver34
lung8
lymph node33
mammary gland39
mouth45
muscle18
ovary19
pancreas9
pharynx49
placenta17
prostate15
salivary gland98
skin18
spleen56
stomach41
testis27
thymus62
thyroid21
trachea19
uterus21
vascular154
Health State
TissuesTPM*
normal25
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma12
colorectal tumor35
esophageal tumor57
gastrointestinal tumor67
germ cell tumor34
glioma27
head and neck tumor37
leukemia84
liver tumor62
lymphoma13
non-neoplasia20
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS78
prostate cancer19
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult26
embryoid body71
blastocyst81
neonate32
fetus44
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.8
adrenal gland2.8
appendix5.6
bone marrow5.5
cerebral cortex2.9
colon4.5
duodenum9.2
esophagus4.4
gallbladder4.5
heart muscle1.8
kidney2.1
liver2.3
lung2.9
lymph node6.8
ovary3.6
pancreas1.4
placenta4
prostate4.9
salivary gland2.8
skin3.9
small intestine6.7
spleen3.7
stomach2.7
testis5.5
thyroid gland5.7
urinary bladder5.4
Tissues
TissuesExpression level
appendixHigh
breastLow
cerebellumLow
cerebral cortexLow
colonLow
duodenumMedium
esophagusLow
hippocampusLow
kidneyLow
lateral ventricleLow
liverLow
lymph nodeHigh
placentaLow
rectumLow
small intestineLow
spleenMedium
testisMedium
tonsilMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605256, gene) Rad18, s. cerevisiae, homolog of; RAD18OMIM


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