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> Protein (NX_Q9NSE2)
Protein (NX_Q9NSE2)
Protein
Gene SymbolCISH to neXtProt (NX_Q9NSE2)
DescriptionCytokine-inducible SH2-containing protein
Chromosome3
Location3p21.2 (50643921 ~ 50649262) to Ensembl
Sequene Features : Isoforms 3, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.JAK-STAT cascade involved in growth hormone signaling pathway
.negative regulation of insulin receptor signaling pathway
.negative regulation of JAK-STAT cascade
  + 6 more...
.protein kinase inhibitor activity .plasma membrane
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 36 0
2014-09-19protein level
3 23 0
2014-05-27protein level
3 23 0
2014-02-25protein level
3 23 0
2013-12-09protein level
3 16 0
2013-11-01protein level
3 16 0
2013-09-12protein level
3 16 0
2013-08-17protein level
3 16 0
2013-07-15protein level
3 12 0
2013-06-11protein level
3 12 0
2013-02-12protein level
3 10 0
2012-12-20protein level
3 10 0
2012-10-30protein level
3 12 0
2012-10-07protein level
3 12 0
2012-08-24protein level
3 9 0
2012-07-28protein level
3 9 0
2012-06-08protein level
3 9 0
2012-05-07protein level
3 9 0
2012-04-10protein level
3 9 0
2012-01-13protein level
3 4 0
2011-12-20protein level
3 4 0
2011-11-11protein level
3 4 0
2011-08-23protein level
3 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NSE2-1
1 11 0 28644.6547
NX_Q9NSE2-2
1 11 0 29269.0201
NX_Q9NSE2-3
1 11 0 30714.4779
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-617866,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-617866,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood40
bone13
bone marrow82
brain4
connective tissue13
intestine8
kidney23
larynx42
lung8
lymph node22
mammary gland33
ovary98
parathyroid48
pharynx24
placenta88
prostate15
salivary gland49
skin4
spleen18
testis4
thymus12
uterus21
Health State
TissuesTPM*
normal24
breast (mammary gland) tumor32
chondrosarcoma24
colorectal tumor17
germ cell tumor30
glioma18
head and neck tumor7
leukemia42
non-neoplasia10
ovarian tumor91
primitive neuroectodermal tumor of the CNS23
prostate cancer9
uterine tumor55
Developmental Stage
TissuesTPM*
adult44
fetus8
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.9
adrenal gland4
appendix9.2
bone marrow5.5
colon8.5
duodenum11
esophagus5.6
gallbladder4.9
heart muscle11.6
kidney27.7
liver17.6
lung19.6
lymph node9
ovary10.3
pancreas7.1
placenta25.3
prostate5
salivary gland10.5
skin6.4
small intestine8.8
spleen6.6
stomach8.1
testis2.3
thyroid gland31.4
urinary bladder5.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602441, gene) Cytokine-inducible sh2-containing protein; CISHOMIM
2(#607948, phenotype) Mycobacterium tuberculosis, susceptibility toOMIM
3(#611162, phenotype) Malaria, susceptibility toOMIM
4(#614383, phenotype) Bacteremia, susceptibility to, 2; BACTS2OMIM


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