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> Protein (NX_Q9NSK0)
Protein (NX_Q9NSK0)
Protein
Gene SymbolKLC4 to neXtProt (NX_Q9NSK0)
DescriptionKinesin light chain 4
Chromosome6
Location6p21.1 (43008515 ~ 43042837) to Ensembl
Sequene Features : Isoforms 5, Variants 93, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .microtubule motor activity .microtubule
.kinesin complex
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 93 12
2014-09-19protein level
4 78 12
2014-05-27protein level
4 75 13
2014-02-25protein level
4 75 13
2013-12-09protein level
4 57 13
2013-11-01protein level
4 50 12
2013-09-12protein level
4 50 12
2013-08-17protein level
4 50 12
2013-07-15protein level
4 36 12
2013-06-11protein level
4 36 12
2013-02-12protein level
4 20 33
2012-12-20protein level
4 18 33
2012-10-30protein level
4 23 33
2012-10-07protein level
4 23 13
2012-08-24protein level
4 22 13
2012-07-28protein level
4 21 13
2012-06-08protein level
4 25 13
2012-05-07protein level
4 21 13
2012-04-10protein level
3 19 13
2012-01-13protein level
3 18 13
2011-12-20protein level
3 18 13
2011-11-11protein level
3 18 11
2011-08-23protein level
3 18 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NSK0-1
0 27 8 68597.4268
NX_Q9NSK0-2
2 4 0 13673.6972
NX_Q9NSK0-3
1 27 8 70508.436
NX_Q9NSK0-4
2 12 5 35080.5089
NX_Q9NSK0-5
1 24 5 59603.8614
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-949319,EBI-742268 TADA2A  
  .histone H3 acetylation
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.chromatin organization
.zinc ion binding
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.chromosome
.nucleus
.PCAF complex
2 EBI-949319,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
3 EBI-949319,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
4 EBI-949319,EBI-10232636 SLC16A9  
  .urate metabolic process
.ion transmembrane transport
.monocarboxylic acid transport
.symporter activity
.monocarboxylic acid transmembrane transporter activity
.integral component of membrane
.plasma membrane
5 EBI-949319,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
6 EBI-949319,EBI-7131783 SYNE4  
  .establishment of epithelial cell apical/basal polarity .N/A .LINC complex
.integral component of nuclear outer membrane
7 EBI-949319,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
8 EBI-949319,EBI-743591 KATNAL1  
  .microtubule severing
.cytoplasmic microtubule organization
.metabolic process
.spermatogenesis
.microtubule-severing ATPase activity
.ATP binding
.microtubule
.cytoplasm
.nucleus
9 EBI-949319,EBI-742038 ABI3  
  .regulation of cell migration
.movement of cell or subcellular component
.N/A .lamellipodium
.membrane
.cytoplasm
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites50
bladder33
blood16
bone83
bone marrow82
brain113
cervix61
connective tissue60
embryonic tissue14
eye76
heart11
intestine181
kidney104
liver87
lung71
mammary gland59
mouth151
muscle37
nerve193
ovary19
pancreas18
placenta24
prostate68
salivary gland49
skin56
spleen56
stomach20
testis48
thymus125
thyroid85
tonsil58
trachea231
umbilical cord72
uterus43
vascular77
Health State
TissuesTPM*
normal81
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma60
colorectal tumor79
gastrointestinal tumor33
germ cell tumor53
glioma65
head and neck tumor104
kidney tumor58
leukemia21
liver tumor104
lung tumor68
lymphoma55
non-neoplasia93
pancreatic tumor38
primitive neuroectodermal tumor of the CNS78
prostate cancer9
retinoblastoma107
skin tumor47
soft tissue/muscle tissue tumor31
uterine tumor77
Developmental Stage
TissuesTPM*
adult44
embryoid body14
blastocyst16
neonate128
fetus129
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.3
adrenal gland14.7
appendix13.3
bone marrow8.6
cerebral cortex16.7
colon36.2
duodenum70.8
esophagus9.9
gallbladder20.1
heart muscle20.2
kidney30.4
liver47.6
lung20.3
lymph node12.9
ovary22
pancreas8.5
placenta11.8
prostate17.8
salivary gland16.9
skin15.9
small intestine62.1
spleen15
stomach35.6
testis24.5
thyroid gland19.7
urinary bladder15.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastMedium
bronchusHigh
cerebellumLow
cerebral cortexLow
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
kidneyHigh
lateral ventricleLow
liverMedium
lungMedium
lymph nodeLow
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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