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> Protein (NX_Q9NTX7)
Protein (NX_Q9NTX7)
Protein
Gene SymbolRNF146 to neXtProt (NX_Q9NTX7)
DescriptionE3 ubiquitin-protein ligase RNF146
Chromosome6
Location6q22.33 (127587755 ~ 127609712) to Ensembl
Sequene Features : Isoforms 2, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of canonical Wnt signaling pathway
.protein K48-linked ubiquitination
.protein autoubiquitination
  + 2 more...
.poly-ADP-D-ribose binding
.ubiquitin protein ligase activity
.ligase activity
  + 2 more...
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 34 4
2014-09-19protein level
2 25 4
2014-05-27protein level
2 25 4
2014-02-25protein level
2 25 4
2013-12-09protein level
2 23 4
2013-11-01protein level
2 22 4
2013-09-12protein level
2 22 4
2013-08-17protein level
2 22 4
2013-07-15protein level
2 11 4
2013-06-11protein level
2 11 4
2013-02-12protein level
2 7 8
2012-12-20protein level
2 7 8
2012-10-30protein level
2 7 8
2012-10-07protein level
2 7 4
2012-08-24protein level
2 7 0
2012-07-28protein level
2 7 0
2012-06-08protein level
2 14 0
2012-05-07protein level
2 12 0
2012-04-10protein level
2 12 0
2012-01-13protein level
2 9 0
2011-12-20protein level
2 9 0
2011-11-11protein level
2 9 0
2011-08-23protein level
2 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NTX7-1
1 14 0 38925.7191
NX_Q9NTX7-2
1 14 0 38794.6789
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-722397,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
2 EBI-722397,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
3 EBI-722397,EBI-1052544 TUBGCP4  
  .microtubule nucleation
.protein complex assembly
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.structural constituent of cytoskeleton .recycling endosome
.membrane
.microtubule cytoskeleton
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder66
blood16
bone55
bone marrow20
brain48
cervix123
connective tissue53
ear124
embryonic tissue42
esophagus49
eye28
heart44
intestine25
kidney75
liver4
lung26
lymph22
lymph node33
mammary gland13
mouth30
muscle18
nerve64
ovary19
pancreas28
parathyroid145
pharynx24
pituitary gland121
placenta56
prostate10
skin9
spleen18
stomach52
testis66
thymus12
thyroid64
tonsil58
trachea38
umbilical cord72
uterus30
vascular77
Health State
TissuesTPM*
normal48
breast (mammary gland) tumor10
chondrosarcoma96
colorectal tumor8
esophageal tumor57
gastrointestinal tumor42
germ cell tumor60
glioma9
head and neck tumor14
kidney tumor14
leukemia10
lung tumor19
lymphoma13
non-neoplasia31
ovarian tumor52
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
prostate cancer9
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor23
uterine tumor22
Developmental Stage
TissuesTPM*
adult39
embryoid body57
blastocyst32
neonate32
fetus53
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue38.3
adrenal gland35.3
appendix29
bone marrow5.3
cerebral cortex40.9
colon21
duodenum13.9
esophagus19.4
gallbladder32.5
heart muscle36.6
kidney30.3
liver13.5
lung32
lymph node26.5
ovary38.1
pancreas10.1
placenta33.1
prostate27.3
salivary gland20.4
skin17.3
small intestine18.4
spleen36.8
stomach18.7
testis29.1
thyroid gland33.9
urinary bladder24.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowLow
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusLow
kidneyMedium
liverMedium
lungLow
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryLow
pancreasLow
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Medium
spleenLow
stomach 1Low
stomach 2Low
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612137, gene) Ring finger protein 146; RNF146OMIM


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