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> Protein (NX_Q9NU19)
Protein (NX_Q9NU19)
Protein
Gene SymbolTBC1D22B to neXtProt (NX_Q9NU19)
DescriptionTBC1 domain family member 22B
Chromosome6
Location6p21.2 (37225548 ~ 37300746) to Ensembl
Sequene Features : Isoforms 1, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .GTPase activator activity .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 50 2
2014-09-19protein level
1 41 2
2014-05-27protein level
1 41 2
2014-02-25protein level
1 41 2
2013-12-09protein level
1 31 2
2013-11-01protein level
1 27 2
2013-09-12protein level
1 27 2
2013-08-17protein level
1 27 2
2013-07-15protein level
1 22 2
2013-06-11protein level
1 22 2
2013-02-12protein level
1 10 1
2012-12-20protein level
1 10 1
2012-10-30protein level
1 11 1
2012-10-07protein level
1 11 1
2012-08-24protein level
1 10 1
2012-07-28protein level
1 9 1
2012-06-08protein level
1 10 1
2012-05-07protein level
1 9 1
2012-04-10protein level
1 9 1
2012-01-13protein level
1 2 1
2011-12-20protein level
1 2 1
2011-11-11protein level
1 2 1
2011-08-23protein level
1 2 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NU19-1
25 0 3 59044.0186
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8787464,EBI-741237 SORBS3  
  .positive regulation of stress fiber assembly
.positive regulation of cytoskeleton organization
.positive regulation of MAPK cascade
  + 5 more...
.vinculin binding
.structural constituent of cytoskeleton
.focal adhesion
.cytoskeleton
.cytosol
.nucleus
2 EBI-8787464,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-8787464,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
4 EBI-8787464,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
5 EBI-8787464,EBI-721525 RBM10  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding
.identical protein binding
.protein complex binding
  + 2 more...
.nucleoplasm
.nucleus
6 EBI-8787464,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
7 EBI-8787464,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
8 EBI-8787464,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
9 EBI-8787464,EBI-2808286 CCDC57  
  .N/A .N/A .N/A
10 EBI-8787464,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
11 EBI-8787464,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
12 EBI-8787464,EBI-742397 TEX11  
  .chiasma assembly
.negative regulation of apoptotic process
.fertilization
  + 6 more...
.N/A .central element
13 EBI-8787464,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
14 EBI-8787464,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
15 EBI-8787464,EBI-742664 HSD17B14  
  .steroid catabolic process .testosterone 17-beta-dehydrogenase (NADP+) activity
.estradiol 17-beta-dehydrogenase activity
.cytosol
16 EBI-8787464,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
17 EBI-8787464,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
18 EBI-8787464,EBI-2554984 TACC3  
  .regulation of cell cycle
.cytoplasmic sequestering of transcription factor
.regulation of microtubule-based process
  + 8 more...
.N/A .centrosome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
blood24
bone27
bone marrow20
brain49
cervix20
connective tissue26
embryonic tissue18
esophagus49
eye43
intestine30
kidney4
liver9
lung41
lymph90
lymph node44
mammary gland13
mouth241
muscle28
ovary19
pancreas23
placenta14
prostate36
skin18
spleen18
stomach10
testis48
thymus100
thyroid64
trachea115
uterus30
Health State
TissuesTPM*
normal39
adrenal tumor158
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma24
colorectal tumor26
esophageal tumor57
gastrointestinal tumor8
germ cell tumor34
glioma18
head and neck tumor127
kidney tumor14
leukemia10
liver tumor10
lung tumor68
lymphoma110
non-neoplasia41
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS31
prostate cancer19
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult27
blastocyst48
neonate32
fetus57
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.7
adrenal gland8.2
appendix4.7
bone marrow9.9
cerebral cortex5.2
colon6.3
duodenum6.6
esophagus8.8
gallbladder6.4
heart muscle4.1
kidney6.3
liver1.8
lung6.2
lymph node5.2
ovary6
pancreas5.8
placenta5.9
prostate4.6
salivary gland7.8
skin7.6
small intestine7.3
spleen5
stomach4.7
testis10.9
thyroid gland7.7
urinary bladder6.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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