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> Protein (NX_Q9NUY8)
Protein (NX_Q9NUY8)
Protein
Gene SymbolTBC1D23 to neXtProt (NX_Q9NUY8)
DescriptionTBC1 domain family member 23
Chromosome3
Location3q12.1 (99979844 ~ 100044095) to Ensembl
Sequene Features : Isoforms 2, Variants 69, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of inflammatory response
.positive regulation of interleukin-6 production
.regulation of tumor necrosis factor production
.N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 69 5
2014-09-19protein level
2 53 5
2014-05-27protein level
2 53 5
2014-02-25protein level
2 53 5
2013-12-09protein level
2 41 5
2013-11-01protein level
2 40 5
2013-09-12protein level
2 40 5
2013-08-17protein level
2 40 5
2013-07-15protein level
2 27 5
2013-06-11protein level
2 27 5
2013-02-12protein level
2 16 8
2012-12-20protein level
2 16 8
2012-10-30protein level
2 16 8
2012-10-07protein level
2 16 4
2012-08-24protein level
2 15 4
2012-07-28protein level
2 15 4
2012-06-08protein level
2 19 4
2012-05-07protein level
2 11 4
2012-04-10protein level
2 11 4
2012-01-13protein level
2 9 4
2011-12-20protein level
2 9 4
2011-11-11protein level
2 9 4
2011-08-23protein level
2 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NUY8-1
1 30 0 78271.9034
NX_Q9NUY8-2
0 30 0 76452.0949
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2853126,EBI-714790 WDR62  
  .neurogenesis
.cerebral cortex development
.N/A .cytoplasm
.nucleoplasm
.nucleus
.spindle pole
2 EBI-2853126,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
3 EBI-10314276,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
4 EBI-2853126,EBI-10196469 CAGE1  
  .N/A .N/A .N/A
5 EBI-2853126,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
6 EBI-2853126,EBI-2902395 SSBP3  
  .positive regulation of anterior head development
.head morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
  + 6 more...
.single-stranded DNA binding .protein complex
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood57
bone41
bone marrow61
brain95
connective tissue26
ear124
embryonic tissue18
eye28
heart67
intestine21
kidney61
liver43
lung50
lymph node89
mammary gland33
mouth136
muscle37
ovary39
pancreas18
pharynx49
placenta67
prostate15
salivary gland98
skin33
spleen56
stomach52
testis110
thymus62
thyroid21
tonsil58
trachea444
umbilical cord363
uterus77
vascular19
Health State
TissuesTPM*
normal66
adrenal tumor79
breast (mammary gland) tumor10
chondrosarcoma36
colorectal tumor35
gastrointestinal tumor33
germ cell tumor72
glioma27
head and neck tumor67
kidney tumor72
leukemia21
liver tumor20
lymphoma13
non-neoplasia51
ovarian tumor39
pancreatic tumor28
primitive neuroectodermal tumor of the CNS31
prostate cancer9
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor39
uterine tumor44
Developmental Stage
TissuesTPM*
adult39
embryoid body42
blastocyst16
neonate225
fetus64
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.3
adrenal gland22.5
appendix15.9
bone marrow22.9
cerebral cortex12.5
colon16.7
duodenum19.2
esophagus18.1
gallbladder17
heart muscle13.2
kidney15.8
liver13.4
lung14.3
lymph node15.4
ovary17
pancreas8.8
placenta21.2
prostate13.4
salivary gland12.5
skin19.7
small intestine18.1
spleen13
stomach16.4
testis18.3
thyroid gland15.4
urinary bladder18.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasHigh
parathyroid glandLow
placentaMedium
prostateMedium
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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