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> Protein (NX_Q9NVV9)
Protein (NX_Q9NVV9)
Protein
Gene SymbolTHAP1 to neXtProt (NX_Q9NVV9)
DescriptionTHAP domain-containing protein 1
Chromosome8
Location8p11.21 (42691817 ~ 42698468) to Ensembl
Sequene Features : Isoforms 2, Variants 67, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 67 0
2014-09-19protein level
2 63 0
2014-05-27protein level
2 63 0
2014-02-25protein level
2 63 0
2013-12-09protein level
2 62 0
2013-11-01protein level
2 62 0
2013-09-12protein level
2 62 0
2013-08-17protein level
2 62 0
2013-07-15protein level
2 55 0
2013-06-11protein level
2 55 0
2013-02-12protein level
2 49 0
2012-12-20protein level
2 49 0
2012-10-30protein level
1 48 0
2012-10-07protein level
1 48 0
2012-08-24protein level
1 46 0
2012-07-28protein level
1 46 0
2012-06-08protein level
1 90 0
2012-05-07protein level
1 90 0
2012-04-10protein level
1 88 0
2012-01-13protein level
1 89 0
2011-12-20protein level
1 56 0
2011-11-11protein level
1 56 0
2011-08-23protein level
1 49 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NVV9-1
6 2 0 24927.6657
NX_Q9NVV9-2
1 2 0 6488.3444
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741515,EBI-948905 ACOT7  
  .palmitic acid biosynthetic process
.medium-chain fatty acid biosynthetic process
.long-chain fatty-acyl-CoA catabolic process
  + 3 more...
.carboxylic ester hydrolase activity
.protein homodimerization activity
.long-chain fatty acyl-CoA binding
  + 2 more...
.extracellular exosome
.cell body
.neuron projection
  + 4 more...
2 EBI-741515,EBI-523498 TRAF5  
  .positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 4 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
  + 2 more...
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
3 EBI-741515,EBI-1210503 CHD2  
  .hematopoietic stem cell differentiation
.DNA duplex unwinding
.chromatin modification
  + 4 more...
.poly(A) RNA binding
.histone binding
.ATP binding
  + 3 more...
.extracellular exosome
.intracellular membrane-bounded organelle
.nucleolus
  + 2 more...
4 EBI-741515,EBI-750559 SLU7  
  .cellular response to heat
.intracellular protein transport
.mRNA splicing, via spliceosome
  + 3 more...
.pre-mRNA 3'-splice site binding
.zinc ion binding
.second spliceosomal transesterification activity
.catalytic step 2 spliceosome
.intracellular membrane-bounded organelle
.small nuclear ribonucleoprotein complex
  + 6 more...
5 EBI-741515,EBI-515331 YES1  
  .cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
6 EBI-741515,EBI-742339 U2AF2  
  .negative regulation of mRNA splicing, via spliceosome
.positive regulation of RNA splicing
.mRNA 3'-end processing
  + 7 more...
.poly(A) RNA binding
.enzyme binding
.nucleotide binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
7 EBI-741515,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
8 EBI-741515,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
9 EBI-741515,EBI-353054 RPS25  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 9 more...
.poly(A) RNA binding
.structural constituent of ribosome
.RNA binding
.extracellular exosome
.cytosolic small ribosomal subunit
.small ribosomal subunit
  + 5 more...
10 EBI-741515,EBI-359527 POLR2L  
  .positive regulation of viral transcription
.negative regulation of gene expression, epigenetic
.innate immune response
  + 23 more...
.zinc ion binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
  + 3 more...
11 EBI-741515,EBI-432924 AP2B1  
  .clathrin-mediated endocytosis
.regulation of defense response to virus by virus
.ephrin receptor signaling pathway
  + 8 more...
.clathrin binding
.protein transporter activity
.signal sequence binding
.intracellular membrane-bounded organelle
.clathrin-coated endocytic vesicle membrane
.endocytic vesicle membrane
  + 4 more...
12 EBI-741515,EBI-347804 CSNK2A1  
  .mitotic spindle checkpoint
.chaperone-mediated protein folding
.rhythmic process
  + 12 more...
.Hsp90 protein binding
.protein N-terminus binding
.ATP binding
.protein serine/threonine kinase activity
.NuRD complex
.Sin3 complex
.plasma membrane
  + 2 more...
13 EBI-741515,EBI-10172814 PRR20C  
  .N/A .N/A .N/A
14 EBI-741515,EBI-10222656 AKAP17A  
  .regulation of RNA splicing
.B cell activation
.RNA splicing
  + 3 more...
.protein kinase A binding
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.cytoplasm
.spliceosomal complex
  + 2 more...
15 EBI-741515,EBI-10226430 RIPPLY1  
  .bone morphogenesis
.negative regulation of transcription, DNA-templated
.somite rostral/caudal axis specification
  + 4 more...
.N/A .nucleus
16 EBI-741515,EBI-2341136 TRIM26  
  .negative regulation of viral release from host cell
.interferon-gamma-mediated signaling pathway
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 3 more...
.metal ion binding
.zinc ion binding
.DNA binding
.cytosol
17 EBI-741515,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
18 EBI-741515,EBI-396072 PPIG  
  .RNA splicing
.protein folding
.protein peptidyl-prolyl isomerization
.poly(A) RNA binding
.cyclosporin A binding
.peptidyl-prolyl cis-trans isomerase activity
.nuclear speck
.nuclear matrix
.cytoplasm
  + 2 more...
19 EBI-741515,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
20 EBI-741515,EBI-395290 RBM39  
  .RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
21 EBI-741515,EBI-742828 LASP1  
  .positive regulation of signal transduction
.ion transport
.ion transmembrane transporter activity
.zinc ion binding
.SH3/SH2 adaptor activity
.extracellular exosome
.cortical actin cytoskeleton
.focal adhesion
22 EBI-741515,EBI-399257 MORF4L2  
  .positive regulation of striated muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.regulation of growth
  + 4 more...
.N/A .nucleolus
.nucleoplasm
23 EBI-741515,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
24 EBI-741515,EBI-740686 DCAF8  
  .protein ubiquitination .N/A .Cul4-RING E3 ubiquitin ligase complex
.cytoplasm
.nucleus
25 EBI-741515,EBI-10219231 ZNF385C  
  .N/A .zinc ion binding
.nucleic acid binding
.nucleus
26 EBI-741515,EBI-10248982 ARL6IP4  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding .nuclear speck
.nucleolus
.nucleus
27 EBI-741515,EBI-3920396 C11orf57  
  .N/A .N/A .N/A
28 EBI-741515,EBI-7844656 TTLL10  
  .cellular protein modification process .N/A .N/A
29 EBI-741515,EBI-10256685 PID1  
  .negative regulation of glucose import in response to insulin stimulus
.positive regulation of ATP biosynthetic process
.negative regulation of ATP biosynthetic process
  + 19 more...
.N/A .cytoplasm
.nucleoplasm
30 EBI-741515,EBI-741520 RALYL  
  .N/A .poly(A) RNA binding
.identical protein binding
.nucleotide binding
.N/A
31 EBI-741515,EBI-744506 FAM124A  
  .N/A .N/A .N/A
32 EBI-741515,EBI-10268158 FAM133A  
  .N/A .N/A .N/A
33 EBI-741515,EBI-597063 ZCCHC10  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
34 EBI-741515,EBI-535849 HNRNPLL  
  .positive regulation of RNA splicing
.mRNA processing
.poly(A) RNA binding
.mRNA binding
.nucleotide binding
.ribonucleoprotein complex
.membrane
.nucleus
35 EBI-741515,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
36 EBI-741515,EBI-740355 STRBP  
  .mechanosensory behavior
.spermatid development
.multicellular organismal development
.poly(A) RNA binding
.single-stranded RNA binding
.double-stranded RNA binding
.DNA binding
.microtubule cytoskeleton
.cytoplasm
.nucleus
37 EBI-741515,EBI-9641546 AKAP9  
  .positive regulation of potassium ion transmembrane transporter activity
.regulation of heart rate by cardiac conduction
.cellular response to cAMP
  + 11 more...
.ion channel binding
.protein complex scaffold
.potassium channel regulator activity
.receptor binding
.intracellular membrane-bounded organelle
.ciliary basal body
.voltage-gated potassium channel complex
  + 5 more...
38 EBI-741515,EBI-751612 C7orf50  
  .N/A .poly(A) RNA binding .N/A
39 EBI-741515,EBI-742459 MMTAG2  
  .N/A .poly(A) RNA binding .N/A
40 EBI-741515,EBI-5666657 GPATCH2L  
  .N/A .N/A .N/A
41 EBI-741515,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
42 EBI-741515,EBI-751683 SAP30BP  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.positive regulation of cell death
  + 4 more...
.N/A .intermediate filament cytoskeleton
.nucleoplasm
.nucleus
43 EBI-741515,EBI-356517 BAG5  
  .negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.regulation of cellular response to heat
.regulation of inclusion body assembly
  + 7 more...
.chaperone binding
.ubiquitin protein ligase binding
.protein kinase binding
.perinuclear region of cytoplasm
.inclusion body
.membrane
  + 3 more...
44 EBI-741515,EBI-5453723 MRPL11  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
45 EBI-741515,EBI-750750 KLF12  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
  + 3 more...
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
bone13
brain15
connective tissue6
embryonic tissue14
eye28
heart11
intestine21
kidney9
liver14
lung2
lymph22
lymph node44
mammary gland13
muscle18
pharynx24
placenta17
prostate15
salivary gland49
skin4
stomach31
testis20
thyroid21
uterus4
vascular38
Health State
TissuesTPM*
normal16
breast (mammary gland) tumor10
chondrosarcoma24
colorectal tumor8
gastrointestinal tumor16
germ cell tumor11
glioma18
head and neck tumor7
kidney tumor14
leukemia10
lymphoma41
non-neoplasia10
primitive neuroectodermal tumor of the CNS31
prostate cancer19
retinoblastoma21
skin tumor7
Developmental Stage
TissuesTPM*
adult14
embryoid body14
blastocyst16
fetus16
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.5
adrenal gland6.5
appendix7.7
bone marrow5.4
cerebral cortex5.1
colon6.2
duodenum6
esophagus6.3
gallbladder5.6
heart muscle7.2
kidney6.7
liver4.3
lung5.6
lymph node9.6
ovary8.4
pancreas2.3
placenta6.6
prostate5.4
salivary gland4.6
skin3.5
small intestine5.2
spleen5.7
stomach4.8
testis11.1
thyroid gland8.7
urinary bladder8.4
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(#602629, phenotype) Dystonia 6, torsion; DYT6OMIM
2(*609520, gene) Thap domain-containing protein 1; THAP1OMIM


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