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> Protein (NX_Q9NW38)
Protein (NX_Q9NW38)
Protein
Gene SymbolFANCL to neXtProt (NX_Q9NW38)
DescriptionE3 ubiquitin-protein ligase FANCL
Chromosome2
Location2p16.1 (58386378 ~ 58468507) to Ensembl
Sequene Features : Isoforms 2, Variants 47, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell proliferation
.gamete generation
.cellular response to DNA damage stimulus
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.Fanconi anaemia nuclear complex
.cytoplasm
.nucleoplasm
.nuclear envelope
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 47 3
2014-09-19protein level
2 37 3
2014-05-27protein level
2 37 3
2014-02-25protein level
2 37 3
2013-12-09protein level
2 27 3
2013-11-01protein level
2 26 3
2013-09-12protein level
2 26 2
2013-08-17protein level
2 26 2
2013-07-15protein level
2 12 0
2013-06-11protein level
2 12 0
2013-02-12protein level
2 9 0
2012-12-20protein level
2 9 0
2012-10-30protein level
2 10 0
2012-10-07protein level
2 10 0
2012-08-24protein level
2 8 0
2012-07-28protein level
2 8 0
2012-06-08protein level
2 22 0
2012-05-07protein level
2 22 0
2012-04-10protein level
2 22 0
2012-01-13protein level
2 6 0
2011-12-20protein level
2 6 0
2011-11-11protein level
2 6 0
2011-08-23protein level
1 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NW38-1
1 18 0 42876.7023
NX_Q9NW38-2
1 18 0 43401.9555
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2339898,EBI-747754 GRN  
  .positive regulation of epithelial cell proliferation
.embryo implantation
.signal transduction
.blastocyst hatching
.poly(A) RNA binding
.growth factor activity
.extracellular exosome
.intracellular membrane-bounded organelle
.mitochondrion
.extracellular space
2 EBI-2339898,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
3 EBI-2339898,EBI-2512147 RBM45  
  .cell differentiation
.nervous system development
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.cytoplasm
.nucleoplasm
.nucleus
4 EBI-2339898,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
5 EBI-2339898,EBI-10174653 DOCK8  
  .negative regulation of T cell apoptotic process
.memory T cell proliferation
.dendritic cell migration
  + 3 more...
.guanyl-nucleotide exchange factor activity .cell leading edge
.membrane
.cytosol
6 EBI-2339898,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
7 EBI-2339898,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
8 EBI-2339898,EBI-301024 EIF4ENIF1  
  .N/A .poly(A) RNA binding
.protein transporter activity
.intracellular membrane-bounded organelle
.nuclear speck
.PML body
  + 4 more...
9 EBI-2339898,EBI-743375 CHCHD3  
  .mitochondrial fusion
.inner mitochondrial membrane organization
.negative regulation of transcription from RNA polymerase II promoter
.protein complex scaffold
.phosphatase binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
10 EBI-2339898,EBI-10182375 RIMBP3  
  .N/A .N/A .N/A
11 EBI-2339898,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
12 EBI-2339898,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites25
bladder100
bone55
bone marrow20
brain53
connective tissue60
ear124
embryonic tissue61
eye38
heart44
intestine103
kidney9
larynx85
liver14
lung29
lymph22
lymph node100
mammary gland79
muscle9
ovary59
pancreas18
parathyroid48
pharynx73
pituitary gland60
placenta10
prostate21
salivary gland49
skin33
spleen18
stomach20
testis91
thyroid64
trachea19
umbilical cord72
uterus43
vascular38
Health State
TissuesTPM*
normal40
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor128
chondrosarcoma48
colorectal tumor151
gastrointestinal tumor16
germ cell tumor41
glioma9
head and neck tumor37
leukemia21
lung tumor19
lymphoma55
non-neoplasia62
ovarian tumor78
pancreatic tumor19
primitive neuroectodermal tumor of the CNS62
retinoblastoma64
skin tumor39
soft tissue/muscle tissue tumor63
uterine tumor33
Developmental Stage
TissuesTPM*
adult43
embryoid body42
blastocyst97
neonate32
fetus34
infant170
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.1
adrenal gland39.1
appendix12
bone marrow7.1
cerebral cortex16.7
colon12.8
duodenum10.9
esophagus12.7
gallbladder14.5
heart muscle11
kidney8.6
liver11
lung11.3
lymph node18.3
ovary24.9
pancreas6.7
placenta10.8
prostate17
salivary gland13.4
skin16.5
small intestine12.2
spleen15.7
stomach12.8
testis20.9
thyroid gland18.8
urinary bladder15.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyHigh
lateral ventricleMedium
liverLow
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608111, gene) Fancl gene; FANCLOMIM
2(#614083, phenotype) Fanconi anemia, complementation group l; FANCLOMIM


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