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> Protein (NX_Q9NX04)
Protein (NX_Q9NX04)
Protein
Gene SymbolC1orf109 to neXtProt (NX_Q9NX04)
DescriptionUncharacterized protein C1orf109
Chromosome1
Location1p34.3 (38147242 ~ 38157914) to Ensembl
Sequene Features : Isoforms 2, Variants 18, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 18 1
2014-09-19protein level
2 13 1
2014-05-27protein level
2 13 1
2014-02-25protein level
2 13 1
2013-12-09protein level
2 12 1
2013-11-01protein level
2 11 0
2013-09-12protein level
2 11 0
2013-08-17protein level
2 11 0
2013-07-15protein level
2 7 0
2013-06-11protein level
2 7 0
2013-02-12protein level
2 4 0
2012-12-20protein level
2 4 0
2012-10-30protein level
2 4 0
2012-10-07protein level
2 4 0
2012-08-24transcript level
2 4 0
2012-07-28transcript level
2 4 0
2012-06-08transcript level
2 4 0
2012-05-07transcript level
2 4 0
2012-04-10transcript level
2 4 0
2012-01-13transcript level
2 2 0
2011-12-20transcript level
2 2 0
2011-11-11transcript level
2 2 0
2011-08-23transcript level
2 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NX04-1
5 4 0 23358.2583
NX_Q9NX04-2
2 4 0 12852.3249
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8643161,EBI-746202 PLK4  
  .de novo centriole assembly
.trophoblast giant cell differentiation
.positive regulation of centriole replication
  + 5 more...
.ATP binding
.protein serine/threonine kinase activity
.deuterosome
.cleavage furrow
.cytosol
  + 3 more...
2 EBI-8643161,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
3 EBI-8643161,EBI-748171 CRX  
  .retina development in camera-type eye
.response to stimulus
.positive regulation of photoreceptor cell differentiation
  + 5 more...
.leucine zipper domain binding
.nuclear hormone receptor binding
.sequence-specific DNA binding transcription factor activity
  + 3 more...
.transcription factor complex
.nucleus
4 EBI-8643161,EBI-742268 TADA2A  
  .histone H3 acetylation
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.chromatin organization
.zinc ion binding
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.chromosome
.nucleus
.PCAF complex
5 EBI-8643161,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
6 EBI-8643161,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
7 EBI-8643161,EBI-740037 ZBED1  
  .metabolic process .metal ion binding
.transposase activity
.DNA binding
.nuclear chromosome
8 EBI-8643161,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
9 EBI-8643161,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
10 EBI-8643161,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
11 EBI-8643161,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
12 EBI-8643161,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
13 EBI-8643161,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
14 EBI-8643161,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
15 EBI-8643161,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
16 EBI-8643161,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
17 EBI-8643161,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
18 EBI-8643161,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
19 EBI-8643161,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
20 EBI-8643161,EBI-946029 C1orf94  
  .N/A .N/A .N/A
21 EBI-8643161,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
22 EBI-8643161,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
23 EBI-8643161,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
24 EBI-8643161,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
25 EBI-8643161,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
26 EBI-8643161,EBI-8643207 ZNF398  
  .positive regulation of transcription, DNA-templated
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
27 EBI-8643161,EBI-413317 SPAG5  
  .regulation of attachment of spindle microtubules to kinetochore
.cell division
.chromosome segregation
  + 2 more...
.N/A .mitotic spindle
.microtubule plus-end
.midbody
  + 7 more...
28 EBI-8643161,EBI-722877 TCF12  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of neuron differentiation
.muscle organ development
  + 2 more...
.E-box binding
.protein heterodimerization activity
.SMAD binding
  + 7 more...
.RNA polymerase II transcription factor complex
.cytoplasm
.nucleus
.nuclear chromatin
29 EBI-8643161,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
30 EBI-8643161,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
31 EBI-8643161,EBI-743591 KATNAL1  
  .microtubule severing
.cytoplasmic microtubule organization
.metabolic process
.spermatogenesis
.microtubule-severing ATPase activity
.ATP binding
.microtubule
.cytoplasm
.nucleus
32 EBI-8643161,EBI-739784 CINP  
  .cell division
.cell cycle
.DNA repair
.DNA replication
.N/A .nucleus
33 EBI-8643161,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
34 EBI-8643161,EBI-10289057 PPP1R12C  
  .N/A .N/A .cytoplasm
35 EBI-8643161,EBI-2341005 MKRN2  
  .protein ubiquitination .poly(A) RNA binding
.ligase activity
.zinc ion binding
.intracellular
36 EBI-8643161,EBI-2130266 RNF41  
  .positive regulation of reactive oxygen species metabolic process
.regulation of reactive oxygen species metabolic process
.regulation of establishment of cell polarity
  + 12 more...
.ubiquitin protein ligase activity
.protein tag
.Ral GTPase binding
  + 3 more...
.cytosol
37 EBI-8643161,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
38 EBI-8643161,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites50
bladder100
blood32
bone41
bone marrow20
brain47
cervix41
connective tissue13
embryonic tissue18
esophagus148
eye23
heart33
intestine30
kidney37
liver4
lung29
mammary gland33
mouth30
muscle9
nerve64
ovary9
pancreas9
pituitary gland181
placenta21
prostate52
skin14
spleen37
stomach10
testis66
thymus12
trachea38
uterus124
vascular58
Health State
TissuesTPM*
normal31
bladder carcinoma113
breast (mammary gland) tumor32
chondrosarcoma36
colorectal tumor44
esophageal tumor173
gastrointestinal tumor16
germ cell tumor87
glioma9
head and neck tumor7
kidney tumor43
leukemia10
lung tumor38
lymphoma13
non-neoplasia10
ovarian tumor13
primitive neuroectodermal tumor of the CNS31
prostate cancer67
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor31
uterine tumor233
Developmental Stage
TissuesTPM*
adult40
blastocyst32
neonate32
fetus28
infant85
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.1
adrenal gland15.2
appendix12.6
bone marrow7.9
cerebral cortex10.8
colon9.6
duodenum8.1
esophagus14.5
gallbladder11.1
heart muscle9.5
kidney14.2
liver5.9
lung8.9
lymph node15.9
ovary18.5
pancreas9
placenta13.8
prostate15
salivary gland14.2
skin11.5
small intestine8.3
spleen12.6
stomach10.1
testis14
thyroid gland17.2
urinary bladder13.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexLow
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Low
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614799, gene) Chromosome 1 open reading frame 109; C1ORF109OMIM


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