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> Protein (NX_Q9NX47)
Protein (NX_Q9NX47)
Protein
Gene SymbolMARCH5 to neXtProt (NX_Q9NX47)
DescriptionE3 ubiquitin-protein ligase MARCH5
Chromosome10
Location10q23.32 (94050920 ~ 94113721) to Ensembl
Sequene Features : Isoforms 1, Variants 31, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cell aging
.positive regulation of mitochondrial fission
.regulation of mitochondrial fission
  + 3 more...
.GTPase binding
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.integral component of membrane
.membrane
.endoplasmic reticulum membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 31 1
2014-09-19protein level
1 22 1
2014-05-27protein level
1 22 1
2014-02-25protein level
1 22 1
2013-12-09protein level
1 20 1
2013-11-01protein level
1 18 1
2013-09-12protein level
1 18 1
2013-08-17protein level
1 18 1
2013-07-15protein level
1 8 0
2013-06-11protein level
1 8 0
2013-02-12protein level
1 3 0
2012-12-20protein level
1 2 0
2012-10-30protein level
1 3 0
2012-10-07protein level
1 3 0
2012-08-24protein level
1 3 0
2012-07-28protein level
1 3 0
2012-06-08protein level
1 7 0
2012-05-07protein level
1 5 0
2012-04-10protein level
1 5 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NX47-1
15 0 0 31211.1262
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2341610,EBI-716083 DENR  
  .ribosome disassembly
.IRES-dependent translational initiation
.formation of translation preinitiation complex
.translation initiation factor activity .N/A
2 EBI-2341610,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
3 EBI-2341610,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
4 EBI-2341610,EBI-716589 UBE2W  
  .cellular response to misfolded protein
.protein K11-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ubiquitin-like protein transferase activity
  + 3 more...
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
bladder66
blood73
bone69
bone marrow143
brain67
cervix123
connective tissue60
ear62
embryonic tissue32
esophagus99
eye38
heart11
intestine51
kidney23
larynx85
liver14
lung32
lymph node22
mammary gland26
mouth30
muscle18
ovary88
pancreas46
parathyroid48
pharynx24
pituitary gland302
placenta70
prostate68
salivary gland49
skin33
spleen18
stomach20
testis41
thymus727
thyroid21
trachea173
uterus81
vascular19
Health State
TissuesTPM*
normal56
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor173
chondrosarcoma60
colorectal tumor53
esophageal tumor57
gastrointestinal tumor50
germ cell tumor30
glioma18
head and neck tumor37
kidney tumor29
leukemia42
liver tumor31
lung tumor48
lymphoma13
non-neoplasia72
ovarian tumor78
pancreatic tumor47
primitive neuroectodermal tumor of the CNS94
prostate cancer67
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor95
uterine tumor55
Developmental Stage
TissuesTPM*
adult53
embryoid body57
blastocyst16
fetus62
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.6
adrenal gland23.3
appendix18.3
bone marrow17.9
cerebral cortex20
colon19.3
duodenum23.7
esophagus39.5
gallbladder22.9
heart muscle19.9
kidney26.4
liver19.6
lung15.1
lymph node17.6
ovary23.1
pancreas9.8
placenta17.5
prostate26.6
salivary gland19.1
skin12.6
small intestine22.8
spleen16.8
stomach18.5
testis24.3
thyroid gland34.6
urinary bladder26.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610637, gene) Membrane-associated ring-ch finger protein 5; MARCH5OMIM


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