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> Protein (NX_Q9NX55)
Protein (NX_Q9NX55)
Protein
Gene SymbolHYPK to neXtProt (NX_Q9NX55)
DescriptionHuntingtin-interacting protein K
Chromosome15
Location15q15.3 (44088340 ~ 44095241) to Ensembl
Sequene Features : Isoforms 2, Variants 7, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 7 1
2014-09-19protein level
2 9 1
2014-05-27protein level
2 9 1
2014-02-25protein level
2 9 1
2013-12-09protein level
2 5 1
2013-11-01protein level
2 5 1
2013-09-12protein level
2 5 1
2013-08-17protein level
2 5 1
2013-07-15protein level
2 4 1
2013-06-11protein level
2 4 1
2013-02-12protein level
2 3 4
2012-12-20protein level
2 3 4
2012-10-30protein level
2 2 4
2012-10-07protein level
2 2 2
2012-08-24protein level
2 2 2
2012-07-28protein level
2 2 2
2012-06-08protein level
2 1 2
2012-05-07protein level
2 1 2
2012-04-10protein level
2 1 2
2012-01-13protein level
2 1 2
2011-12-20protein level
2 3 2
2011-11-11protein level
2 3 2
2011-08-23protein level
2 3 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NX55-2
3 3 0 14656.3389
NX_Q9NX55-3
2 3 0 9613.5375
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1048743,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
2 EBI-1048743,EBI-740978 MAGEA1  
  .negative regulation of Notch signaling pathway
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.histone deacetylase binding .plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland151
blood65
bone27
bone marrow20
brain17
cervix20
connective tissue13
ear124
embryonic tissue4
eye19
heart33
intestine38
kidney42
larynx42
liver24
lung5
lymph node22
mammary gland26
muscle84
pancreas42
pharynx49
pituitary gland60
placenta14
prostate47
skin23
spleen18
stomach10
testis13
thymus12
thyroid64
tonsil58
uterus30
Health State
TissuesTPM*
normal26
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma12
colorectal tumor26
germ cell tumor45
glioma18
head and neck tumor29
kidney tumor29
leukemia74
liver tumor10
lung tumor9
non-neoplasia10
pancreatic tumor38
primitive neuroectodermal tumor of the CNS23
prostate cancer48
retinoblastoma43
skin tumor7
soft tissue/muscle tissue tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult24
blastocyst16
fetus16
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.6
adrenal gland3.8
appendix3.4
bone marrow14.6
cerebral cortex2.3
colon4.3
duodenum1.9
esophagus1.5
gallbladder2.5
heart muscle2.2
kidney2.9
liver1.9
lung4.5
lymph node10.4
ovary3.8
placenta2.5
prostate3.7
salivary gland2.2
skin5.8
small intestine2.5
spleen3.2
stomach4.4
testis4.4
thyroid gland2.3
urinary bladder3.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612784, gene) Huntingtin-interacting protein kOMIM


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