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> Protein (NX_Q9NX63)
Protein (NX_Q9NX63)
Protein
Gene SymbolCHCHD3 to neXtProt (NX_Q9NX63)
DescriptionMICOS complex subunit MIC19
Chromosome7
Location7q32.3 (132469629 ~ 132766848) to Ensembl
Sequene Features : Isoforms 1, Variants 27, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mitochondrial fusion
.inner mitochondrial membrane organization
.negative regulation of transcription from RNA polymerase II promoter
.protein complex scaffold
.phosphatase binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 27 5
2014-09-19protein level
1 21 5
2014-05-27protein level
1 21 5
2014-02-25protein level
1 21 5
2013-12-09protein level
1 15 5
2013-11-01protein level
1 15 4
2013-09-12protein level
1 15 5
2013-08-17protein level
1 15 5
2013-07-15protein level
1 8 5
2013-06-11protein level
1 8 5
2013-02-12protein level
1 4 5
2012-12-20protein level
1 4 5
2012-10-30protein level
1 5 5
2012-10-07protein level
1 5 5
2012-08-24protein level
1 4 5
2012-07-28protein level
1 4 5
2012-06-08protein level
1 4 5
2012-05-07protein level
1 4 5
2012-04-10protein level
1 4 5
2012-01-13protein level
1 2 5
2011-12-20protein level
1 2 5
2011-11-11protein level
1 2 5
2011-08-23protein level
1 2 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NX63-1
12 0 0 26136.1514
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-743375,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-743375,EBI-357253 PPP1CA  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.cell division
.branching morphogenesis of an epithelial tube
  + 15 more...
.metal ion binding
.ribonucleoprotein complex binding
.phosphatase activity
.protein serine/threonine phosphatase activity
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 10 more...
3 EBI-743375,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
4 EBI-743375,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
5 EBI-743375,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
6 EBI-743375,EBI-739674 CCDC85B  
  .negative regulation of transcription, DNA-templated
.negative regulation of fat cell differentiation
.negative regulation of cell growth
  + 2 more...
.N/A .centrosome
.cytoplasm
.nucleus
7 EBI-743375,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
8 EBI-743375,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
9 EBI-743375,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
10 EBI-743375,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
11 EBI-743375,EBI-745707 GMCL1P1  
  .cell differentiation
.protein ubiquitination
.spermatogenesis
.multicellular organismal development
.N/A .nuclear matrix
12 EBI-743375,EBI-1050213 RPGRIP1  
  .retina development in camera-type eye
.response to stimulus
.eye photoreceptor cell development
.visual perception
.N/A .photoreceptor connecting cilium
.axoneme
13 EBI-743375,EBI-747844 RAB3IP  
  .positive regulation of GTPase activity
.cilium assembly
.protein localization to organelle
  + 3 more...
.Rab guanyl-nucleotide exchange factor activity .ciliary basal body
.lamellipodium
.cytoskeleton
  + 3 more...
14 EBI-743375,EBI-413317 SPAG5  
  .regulation of attachment of spindle microtubules to kinetochore
.cell division
.chromosome segregation
  + 2 more...
.N/A .mitotic spindle
.microtubule plus-end
.midbody
  + 7 more...
15 EBI-743375,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
16 EBI-743375,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
17 EBI-743375,EBI-2339898 FANCL  
  .regulation of cell proliferation
.gamete generation
.cellular response to DNA damage stimulus
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ligase activity
  + 2 more...
.Fanconi anaemia nuclear complex
.cytoplasm
.nucleoplasm
.nuclear envelope
18 EBI-743375,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
19 EBI-743375,EBI-748409 SAMM50  
  .protein import into mitochondrial outer membrane
.cellular protein metabolic process
.protein targeting to mitochondrion
.N/A .extracellular exosome
.integral component of membrane
.mitochondrial inner membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland151
ascites175
bladder33
blood49
bone97
bone marrow82
brain46
cervix164
connective tissue187
embryonic tissue65
esophagus49
eye86
heart189
intestine103
kidney71
larynx85
liver58
lung56
lymph45
lymph node22
mammary gland79
mouth15
muscle206
ovary88
pancreas18
parathyroid145
pharynx49
placenta88
salivary gland49
skin166
stomach83
testis39
thyroid42
trachea19
uterus77
vascular38
Health State
TissuesTPM*
normal54
adrenal tumor316
bladder carcinoma56
breast (mammary gland) tumor85
cervical tumor173
chondrosarcoma108
colorectal tumor106
esophageal tumor57
gastrointestinal tumor135
germ cell tumor60
glioma93
head and neck tumor44
kidney tumor101
leukemia63
liver tumor93
lung tumor58
lymphoma83
non-neoplasia10
ovarian tumor78
pancreatic tumor19
primitive neuroectodermal tumor of the CNS196
retinoblastoma258
skin tumor183
soft tissue/muscle tissue tumor271
uterine tumor55
Developmental Stage
TissuesTPM*
adult81
embryoid body71
blastocyst130
fetus57
infant297
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue33.3
adrenal gland27.2
appendix26.8
bone marrow26.7
cerebral cortex15.5
colon44.3
duodenum39.9
esophagus26.3
gallbladder21.3
heart muscle76.1
kidney39.5
liver16.6
lung19.5
lymph node27.8
ovary24.5
pancreas12.4
placenta23.4
prostate24.8
salivary gland16.9
skin11.9
small intestine32.5
spleen18.1
stomach24.7
testis18.3
thyroid gland31.9
urinary bladder28.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*613748, gene) Coiled-coil-helix-coiled-coil-helix domain-containing protein 3; CHCHD3OMIM


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