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> Protein (NX_Q9NXK8)
Protein (NX_Q9NXK8)
Protein
Gene SymbolFBXL12 to neXtProt (NX_Q9NXK8)
DescriptionF-box/LRR-repeat protein 12
Chromosome19
Location19p13.2 (9920943 ~ 9938492) to Ensembl
Sequene Features : Isoforms 2, Variants 39, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein ubiquitination
.ubiquitin-dependent protein catabolic process
.N/A .cytoplasm
.ubiquitin ligase complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 39 1
2014-09-19protein level
2 26 1
2014-05-27protein level
2 26 1
2014-02-25protein level
2 26 1
2013-12-09protein level
2 19 1
2013-11-01protein level
2 19 1
2013-09-12protein level
2 19 1
2013-08-17protein level
2 19 1
2013-07-15protein level
2 16 0
2013-06-11protein level
2 16 0
2013-02-12protein level
2 11 0
2012-12-20protein level
2 12 0
2012-10-30protein level
2 13 0
2012-10-07protein level
2 13 0
2012-08-24protein level
2 12 0
2012-07-28protein level
2 12 0
2012-06-08protein level
2 12 0
2012-05-07protein level
2 12 0
2012-04-10protein level
2 12 0
2012-01-13protein level
2 5 0
2011-12-20protein level
2 5 0
2011-11-11protein level
2 5 0
2011-08-23protein level
2 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NXK8-1
2 11 0 37001.488
NX_Q9NXK8-2
0 11 0 30470.9819
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-719790,EBI-519256 CDKN1C  
  .genetic imprinting
.embryonic placenta morphogenesis
.uterus development
  + 18 more...
.cyclin-dependent protein serine/threonine kinase inhibitor activity .cytoplasm
.nucleus
2 EBI-719790,EBI-10174653 DOCK8  
  .negative regulation of T cell apoptotic process
.memory T cell proliferation
.dendritic cell migration
  + 3 more...
.guanyl-nucleotide exchange factor activity .cell leading edge
.membrane
.cytosol
3 EBI-719790,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
4 EBI-719790,EBI-724829 RNF32  
  .N/A .zinc ion binding .aggresome
.endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood49
bone27
bone marrow20
brain30
cervix103
connective tissue26
embryonic tissue37
esophagus99
eye14
heart33
intestine34
kidney14
liver29
lung50
lymph22
lymph node89
mammary gland33
mouth15
muscle9
ovary9
pancreas4
parathyroid97
placenta67
prostate36
skin14
stomach104
testis45
thymus188
thyroid21
trachea19
umbilical cord72
uterus38
Health State
TissuesTPM*
normal37
breast (mammary gland) tumor32
chondrosarcoma48
esophageal tumor115
gastrointestinal tumor67
germ cell tumor18
glioma55
head and neck tumor7
leukemia105
liver tumor52
lymphoma27
non-neoplasia20
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS55
prostate cancer28
retinoblastoma21
skin tumor7
uterine tumor55
Developmental Stage
TissuesTPM*
adult35
embryoid body71
blastocyst32
neonate64
fetus39
infant127
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.5
adrenal gland7.2
appendix9.7
bone marrow15.3
cerebral cortex5.2
colon10.9
duodenum12.4
esophagus6.3
gallbladder9.1
heart muscle6.8
kidney7.8
liver5.3
lung12.4
lymph node11.3
ovary12.2
pancreas4.6
placenta13.5
prostate10.1
salivary gland6.1
skin7.2
small intestine11.3
spleen12.1
stomach11.3
testis9.5
thyroid gland7.3
urinary bladder8.9
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*609079, gene) F-box and leucine-rich repeat protein 12; FBXL12OMIM


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