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> Protein (NX_Q9NYA4)
Protein (NX_Q9NYA4)
Protein
Gene SymbolMTMR4 to neXtProt (NX_Q9NYA4)
DescriptionMyotubularin-related protein 4
Chromosome17
Location17q22 (56566898 ~ 56595266) to Ensembl
Sequene Features : Isoforms 1, Variants 128, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.peptidyl-tyrosine dephosphorylation
.negative regulation of transforming growth factor beta receptor signaling pathway
  + 5 more...
.metal ion binding
.protein tyrosine phosphatase activity
.protein serine/threonine phosphatase activity
.early endosome membrane
.cytosol
.extracellular space
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 128 3
2014-09-19protein level
1 97 3
2014-05-27protein level
1 97 3
2014-02-25protein level
1 97 3
2013-12-09protein level
1 73 3
2013-11-01protein level
1 68 3
2013-09-12protein level
1 68 2
2013-08-17protein level
1 68 2
2013-07-15protein level
1 44 0
2013-06-11protein level
1 44 0
2013-02-12transcript level
1 24 0
2012-12-20transcript level
1 22 0
2012-10-30transcript level
1 31 0
2012-10-07transcript level
1 31 0
2012-08-24transcript level
1 21 0
2012-07-28transcript level
1 21 0
2012-06-08transcript level
1 21 0
2012-05-07transcript level
1 20 0
2012-04-10transcript level
1 20 0
2012-01-13transcript level
1 7 0
2011-12-20transcript level
1 7 0
2011-11-11transcript level
1 7 0
2011-08-23transcript level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NYA4-1
55 0 1 133267.2525
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1052346,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
2 EBI-1052346,EBI-1040141 SMAD2  
  .positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder33
blood32
bone55
bone marrow41
brain53
connective tissue13
embryonic tissue51
esophagus49
eye43
heart55
intestine21
kidney80
larynx85
liver38
lung41
lymph22
lymph node133
mammary gland52
muscle47
nerve128
ovary9
pancreas51
pharynx49
pituitary gland60
placenta74
prostate31
skin42
spleen18
stomach10
testis52
thymus37
trachea19
umbilical cord145
uterus60
vascular38
Health State
TissuesTPM*
normal63
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor75
chondrosarcoma96
esophageal tumor57
gastrointestinal tumor8
germ cell tumor79
glioma55
head and neck tumor22
kidney tumor72
leukemia21
liver tumor62
lung tumor19
lymphoma96
non-neoplasia51
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
prostate cancer19
retinoblastoma129
skin tumor39
uterine tumor44
Developmental Stage
TissuesTPM*
adult58
embryoid body71
blastocyst32
neonate96
fetus70
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.2
adrenal gland13
appendix18.1
bone marrow15.6
cerebral cortex21.3
colon15.1
duodenum21.4
esophagus10.6
gallbladder9.1
heart muscle8
kidney15.3
liver17.6
lung10.4
lymph node21.6
ovary18.1
pancreas3.2
placenta30.4
prostate16
salivary gland9.1
skin13.7
small intestine21.7
spleen19.8
stomach11.7
testis23.9
thyroid gland19.5
urinary bladder11.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603559, gene) Myotubularin-related protein 4; MTMR4OMIM


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