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> Protein (NX_Q9NYB0)
Protein (NX_Q9NYB0)
Protein
Gene SymbolTERF2IP to neXtProt (NX_Q9NYB0)
DescriptionTelomeric repeat-binding factor 2-interacting protein 1
Chromosome16
Location16q23.1 (75681684 ~ 75795770) to Ensembl
Sequene Features : Isoforms 1, Variants 37, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein acetylation
.protein localization to chromosome, telomeric region
.positive regulation of NF-kappaB transcription factor activity
  + 11 more...
.DNA binding .cytoplasm
.nucleoplasm
.nuclear envelope
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 37 11
2014-09-19protein level
1 22 11
2014-05-27protein level
1 22 11
2014-02-25protein level
1 22 11
2013-12-09protein level
1 16 11
2013-11-01protein level
1 15 10
2013-09-12protein level
1 15 10
2013-08-17protein level
1 15 10
2013-07-15protein level
1 7 8
2013-06-11protein level
1 7 8
2013-02-12protein level
1 5 7
2012-12-20protein level
1 5 7
2012-10-30protein level
1 6 7
2012-10-07protein level
1 6 7
2012-08-24protein level
1 6 7
2012-07-28protein level
1 6 7
2012-06-08protein level
1 7 7
2012-05-07protein level
1 5 7
2012-04-10protein level
1 5 7
2012-01-13protein level
1 11 7
2011-12-20protein level
1 11 7
2011-11-11protein level
1 11 7
2011-08-23protein level
1 11 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NYB0-1
20 0 0 44232.6948
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-750109,EBI-706637 TERF2  
  .negative regulation of cellular senescence
.negative regulation of beta-galactosidase activity
.cellular senescence
  + 15 more...
.protein homodimerization activity
.telomeric DNA binding
.protein C-terminus binding
  + 2 more...
.Golgi apparatus
.cytoplasm
.nucleoplasm
  + 5 more...
2 EBI-750109,EBI-2370740 SLX4  
  .response to intra-S DNA damage checkpoint signaling
.positive regulation of catalytic activity
.DNA double-strand break processing involved in repair via single-strand annealing
  + 4 more...
.5'-flap endonuclease activity
.enzyme activator activity
.Slx1-Slx4 complex
.cell junction
.cytoplasm
.nucleoplasm
3 EBI-750109,EBI-717418 TINF2  
  .protein localization to chromosome, telomeric region
.negative regulation of epithelial cell proliferation
.protein localization to chromosome
  + 6 more...
.telomeric DNA binding .nuclear matrix
.perinucleolar chromocenter
.nucleoplasm
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland212
ascites75
bladder133
blood65
bone55
bone marrow82
brain397
cervix103
connective tissue60
ear434
embryonic tissue42
esophagus148
eye153
heart201
intestine99
kidney118
liver121
lung116
lymph90
lymph node66
mammary gland46
mouth75
muscle75
nerve128
ovary29
pancreas89
parathyroid242
pharynx24
pituitary gland544
placenta70
prostate100
salivary gland98
skin113
spleen280
stomach73
testis209
thymus276
thyroid150
tonsil117
trachea57
umbilical cord72
uterus68
vascular96
Health State
TissuesTPM*
normal186
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor53
cervical tumor144
chondrosarcoma84
colorectal tumor142
esophageal tumor173
gastrointestinal tumor75
germ cell tumor212
glioma195
head and neck tumor74
kidney tumor188
leukemia63
liver tumor114
lung tumor58
lymphoma83
non-neoplasia165
ovarian tumor39
pancreatic tumor28
primitive neuroectodermal tumor of the CNS149
prostate cancer134
retinoblastoma64
skin tumor71
soft tissue/muscle tissue tumor55
uterine tumor22
Developmental Stage
TissuesTPM*
adult107
embryoid body42
blastocyst16
neonate225
fetus201
infant170
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue42.5
adrenal gland89.1
appendix40.6
bone marrow58.7
cerebral cortex115.5
colon28.6
duodenum24.2
esophagus28.7
gallbladder40.2
heart muscle51.7
kidney41.4
liver24.9
lung35.7
lymph node62.7
ovary58.1
pancreas17.5
placenta25.4
prostate47.3
salivary gland25
skin27.3
small intestine25
spleen45.9
stomach29.7
testis58.3
thyroid gland53.3
urinary bladder40.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
hippocampusHigh
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasHigh
placentaMedium
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleLow
skeletal muscleLow
skin 1Low
skin 2Medium
small intestineHigh
smooth muscleLow
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605061, gene) Terf2-interacting protein; TERF2IPOMIM


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