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> Protein (NX_Q9NYB9)
Protein (NX_Q9NYB9)
Protein
Gene SymbolABI2 to neXtProt (NX_Q9NYB9)
DescriptionAbl interactor 2
Chromosome2
Location2q33.2 (204192942 ~ 204312446) to Ensembl
Sequene Features : Isoforms 4, Variants 46, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 46 10
2014-09-19protein level
4 32 10
2014-05-27protein level
4 31 10
2014-02-25protein level
4 30 10
2013-12-09protein level
4 27 10
2013-11-01protein level
4 26 10
2013-09-12protein level
4 26 11
2013-08-17protein level
4 26 11
2013-07-15protein level
4 16 9
2013-06-11protein level
4 16 9
2013-02-12protein level
4 10 28
2012-12-20protein level
4 10 28
2012-10-30protein level
4 9 28
2012-10-07protein level
4 9 7
2012-08-24protein level
4 7 7
2012-07-28protein level
4 7 7
2012-06-08protein level
4 15 7
2012-05-07protein level
4 12 7
2012-04-10protein level
4 12 7
2012-01-13protein level
4 12 7
2011-12-20protein level
4 12 7
2011-11-11protein level
4 12 3
2011-08-23protein level
4 12 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NYB9-1
0 15 3 55628.5673
NX_Q9NYB9-2
2 14 3 52413.0061
NX_Q9NYB9-3
4 11 2 44380.8376
NX_Q9NYB9-4
0 15 3 54785.0579
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-743598,EBI-308663 ARHGAP32  
  .regulation of small GTPase mediated signal transduction
.small GTPase mediated signal transduction
.phosphatidylinositol binding
.GTPase activator activity
.postsynaptic membrane
.dendritic spine
.cell junction
  + 7 more...
2 EBI-743598,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
3 EBI-743598,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
4 EBI-743598,EBI-748171 CRX  
  .retina development in camera-type eye
.response to stimulus
.positive regulation of photoreceptor cell differentiation
  + 5 more...
.leucine zipper domain binding
.nuclear hormone receptor binding
.sequence-specific DNA binding transcription factor activity
  + 3 more...
.transcription factor complex
.nucleus
5 EBI-743598,EBI-718488 EFS  
  .intracellular signal transduction
.cell adhesion
.protein domain specific binding .cytoplasm
6 EBI-743598,EBI-346356 WIPF1  
  .response to other organism
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.profilin binding
.actin binding
.cytoplasmic membrane-bounded vesicle
.actin cytoskeleton
.actin filament
  + 2 more...
7 EBI-743598,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
8 EBI-743598,EBI-740402 DTNB  
  .N/A .zinc ion binding .synapse
.cytoplasm
9 EBI-743598,EBI-373258 STAM2  
  .membrane organization
.negative regulation of epidermal growth factor receptor signaling pathway
.endosomal transport
  + 2 more...
.N/A .intracellular membrane-bounded organelle
.early endosome membrane
.cytosol
  + 2 more...
10 EBI-743598,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
11 EBI-743598,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
12 EBI-743598,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
13 EBI-743598,EBI-5544229 PPIF  
  .negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of oxidative phosphorylation uncoupler activity
.regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
  + 16 more...
.cyclosporin A binding
.peptidyl-prolyl cis-trans isomerase activity
.membrane
.mitochondrial matrix
.mitochondrial inner membrane
14 EBI-743598,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
15 EBI-743598,EBI-748201 VASP  
  .protein homotetramerization
.T cell receptor signaling pathway
.cell junction assembly
  + 4 more...
.profilin binding .extracellular exosome
.filopodium membrane
.lamellipodium membrane
  + 6 more...
16 EBI-743598,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
17 EBI-743598,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
18 EBI-743598,EBI-742790 TRIM32  
  .positive regulation of cell motility
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of viral release from host cell
  + 21 more...
.ubiquitin protein ligase activity
.protein self-association
.ubiquitin binding
  + 8 more...
.striated muscle myosin thick filament
.cytosol
.cytoplasm
.nucleus
19 EBI-743598,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
20 EBI-743598,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
21 EBI-743598,EBI-1049638 KRT33B  
  .hair cycle
.aging
.structural molecule activity .extracellular exosome
.intermediate filament
.extracellular space
22 EBI-743598,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
23 EBI-743598,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
24 EBI-743598,EBI-5564642 PRR16  
  .positive regulation of cell size
.positive regulation of translation
.N/A .N/A
25 EBI-743598,EBI-10244997 VARS2  
  .gene expression
.valyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.valine-tRNA ligase activity
.aminoacyl-tRNA editing activity
.mitochondrion
26 EBI-743598,EBI-10188326 KIAA1217  
  .embryonic skeletal system development .N/A .cytoplasm
27 EBI-743598,EBI-744203 IFT20  
  .regulation of autophagic vacuole assembly
.regulation of cilium assembly
.protein localization to cilium
  + 13 more...
.N/A .ciliary base
.ciliary tip
.primary cilium
  + 13 more...
28 EBI-743598,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
29 EBI-743598,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
30 EBI-743598,EBI-746252 GCC1  
  .protein targeting to Golgi .N/A .plasma membrane
.Golgi apparatus
.cytoplasm
.Golgi membrane
31 EBI-743598,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
32 EBI-743598,EBI-2860740 PRAM1  
  .regulation of neutrophil degranulation
.integrin-mediated signaling pathway
.lipid binding .N/A
33 EBI-743598,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
34 EBI-743598,EBI-742909 ARMC7  
  .N/A .N/A .cytoplasm
.nucleus
35 EBI-743598,EBI-1175354 EGLN3  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.regulation of neuron apoptotic process
  + 7 more...
.peptidyl-proline 4-dioxygenase activity
.L-ascorbic acid binding
.oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
.iron ion binding
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
36 EBI-743598,EBI-713619 MRPL44  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.ribonuclease III activity
.ribosome
.mitochondrial inner membrane
37 EBI-743598,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
38 EBI-743598,EBI-465781 BLOC1S6  
  .membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
bladder100
blood40
bone69
bone marrow41
brain194
cervix41
connective tissue40
ear124
embryonic tissue89
esophagus49
eye90
heart55
intestine43
kidney56
larynx42
liver43
lung77
lymph node77
mammary gland33
mouth60
muscle141
nerve64
ovary88
pancreas74
parathyroid97
pituitary gland181
placenta38
prostate47
skin66
spleen37
stomach31
testis124
thymus75
thyroid107
tonsil58
trachea96
umbilical cord145
uterus77
vascular58
Health State
TissuesTPM*
normal111
bladder carcinoma113
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma96
colorectal tumor35
esophageal tumor57
gastrointestinal tumor50
germ cell tumor110
glioma233
head and neck tumor52
kidney tumor72
leukemia63
liver tumor62
lung tumor29
lymphoma13
non-neoplasia20
ovarian tumor118
pancreatic tumor76
primitive neuroectodermal tumor of the CNS55
prostate cancer38
retinoblastoma64
skin tumor55
soft tissue/muscle tissue tumor47
uterine tumor77
Developmental Stage
TissuesTPM*
adult67
embryoid body100
blastocyst65
neonate96
fetus172
infant127
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.5
adrenal gland17.3
appendix13.2
bone marrow3.6
cerebral cortex87.2
colon10.2
duodenum6.1
esophagus17
gallbladder19
heart muscle35.5
kidney23.8
liver6.2
lung19.8
lymph node10.8
ovary32.2
pancreas7
placenta19
prostate21.5
salivary gland7.7
skin8
small intestine9
spleen14.5
stomach11
testis39.1
thyroid gland36.7
urinary bladder18.3
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*606442, gene) Abl interactor 2OMIM


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