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> Protein (NX_Q9NYF0)
Protein (NX_Q9NYF0)
Protein
Gene SymbolDACT1 to neXtProt (NX_Q9NYF0)
DescriptionDapper homolog 1
Chromosome14
Location14q23.1 (59100685 ~ 59115039) to Ensembl
Sequene Features : Isoforms 2, Variants 135, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of G1/S transition of mitotic cell cycle
.regulation of Wnt signaling pathway, planar cell polarity pathway
.negative regulation of canonical Wnt signaling pathway
  + 14 more...
.delta-catenin binding
.protein kinase A binding
.beta-catenin binding
.protein kinase C binding
.synapse
.beta-catenin destruction complex
.cell junction
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 135 3
2014-09-19protein level
2 115 3
2014-05-27protein level
2 115 3
2014-02-25protein level
2 112 3
2013-12-09protein level
2 91 3
2013-11-01protein level
2 91 3
2013-09-12protein level
2 91 3
2013-08-17protein level
2 91 3
2013-07-15protein level
2 61 3
2013-06-11protein level
2 61 3
2013-02-12protein level
2 30 3
2012-12-20protein level
2 29 3
2012-10-30protein level
2 31 3
2012-10-07protein level
2 31 2
2012-08-24transcript level
1 25 0
2012-07-28transcript level
1 25 0
2012-06-08transcript level
1 25 0
2012-05-07transcript level
1 16 0
2012-04-10transcript level
1 16 0
2012-01-13transcript level
1 15 0
2011-12-20transcript level
1 15 0
2011-11-11transcript level
1 15 0
2011-08-23transcript level
1 15 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NYF0-1
3 30 0 90118.2742
NX_Q9NYF0-2
0 30 0 86158.3818
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3951744,EBI-740850 DVL2  
  .positive regulation of canonical Wnt signaling pathway
.planar cell polarity pathway involved in neural tube closure
.cochlea morphogenesis
  + 20 more...
.identical protein binding
.frizzled binding
.clathrin-coated endocytic vesicle
.apical part of cell
.cytoplasmic vesicle
  + 4 more...
2 EBI-3951744,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
3 EBI-3951744,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
4 EBI-3951744,EBI-373586 GSK3B  
  .positive regulation of stem cell differentiation
.negative regulation of glycogen (starch) synthase activity
.negative regulation of type B pancreatic cell development
  + 61 more...
.NF-kappaB binding
.tau-protein kinase activity
.protein kinase A catalytic subunit binding
  + 8 more...
.perinuclear region of cytoplasm
.membrane raft
.dendritic shaft
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain22
connective tissue13
embryonic tissue51
eye23
heart11
intestine12
kidney9
lung8
lymph node11
mammary gland19
mouth45
nerve128
parathyroid48
placenta35
prostate5
stomach20
testis34
thymus12
thyroid21
Health State
TissuesTPM*
normal26
breast (mammary gland) tumor32
chondrosarcoma12
colorectal tumor17
gastrointestinal tumor16
germ cell tumor7
head and neck tumor22
kidney tumor14
leukemia10
lung tumor19
non-neoplasia20
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult19
embryoid body85
blastocyst32
fetus70
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.2
adrenal gland7.8
appendix4.3
cerebral cortex4.3
colon4.1
duodenum4.5
esophagus2.8
gallbladder24.4
heart muscle5.2
kidney5.2
liver2
lung5
lymph node3.9
ovary22
placenta10.3
prostate9.5
salivary gland2.1
small intestine3.6
spleen6.1
stomach6.9
testis10.2
thyroid gland8.5
urinary bladder11.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#182940, phenotype) Neural tube defectsOMIM
2(*607861, gene) Dapper, antagonist of beta-catenin, 1; DACT1OMIM


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