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> Protein (NX_Q9NYF3)
Protein (NX_Q9NYF3)
Protein
Gene SymbolFAM53C to neXtProt (NX_Q9NYF3)
DescriptionProtein FAM53C
Chromosome5
Location5q31.2 (137667624 ~ 137685416) to Ensembl
Sequene Features : Isoforms 1, Variants 49, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 49 9
2014-09-19protein level
1 33 9
2014-05-27protein level
1 33 9
2014-02-25protein level
1 33 8
2013-12-09protein level
1 26 8
2013-11-01protein level
1 26 8
2013-09-12protein level
1 26 8
2013-08-17protein level
1 26 8
2013-07-15protein level
1 22 8
2013-06-11protein level
1 22 8
2013-02-12protein level
1 8 9
2012-12-20protein level
1 10 9
2012-10-30protein level
1 11 9
2012-10-07protein level
1 11 9
2012-08-24protein level
1 11 9
2012-07-28protein level
1 11 9
2012-06-08protein level
1 11 9
2012-05-07protein level
1 10 9
2012-04-10protein level
1 10 9
2012-01-13protein level
1 7 9
2011-12-20protein level
1 7 9
2011-11-11protein level
1 7 9
2011-08-23protein level
1 7 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NYF3-1
16 0 0 43064.3276
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1644252,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-1644252,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
3 EBI-1644252,EBI-359832 YWHAG  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 14 more...
.poly(A) RNA binding
.protein kinase C inhibitor activity
.insulin-like growth factor receptor binding
.protein kinase C binding
.extracellular exosome
.cytoplasmic vesicle membrane
.membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
blood24
bone83
bone marrow61
brain131
cervix144
connective tissue46
embryonic tissue70
esophagus99
eye52
heart44
intestine51
kidney14
liver24
lung47
lymph node55
mammary gland72
mouth90
muscle56
nerve64
ovary29
pancreas56
parathyroid48
placenta56
prostate36
skin113
spleen18
testis174
thymus112
thyroid85
tonsil58
trachea212
umbilical cord72
uterus90
vascular38
Health State
TissuesTPM*
normal76
breast (mammary gland) tumor64
cervical tumor86
chondrosarcoma96
colorectal tumor17
esophageal tumor115
gastrointestinal tumor25
germ cell tumor113
glioma139
head and neck tumor74
leukemia52
liver tumor41
lung tumor29
non-neoplasia20
ovarian tumor65
pancreatic tumor104
primitive neuroectodermal tumor of the CNS31
prostate cancer57
retinoblastoma43
skin tumor79
soft tissue/muscle tissue tumor127
uterine tumor55
Developmental Stage
TissuesTPM*
adult58
embryoid body85
blastocyst48
neonate128
fetus48
infant127
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.4
adrenal gland12.6
appendix15.1
bone marrow54.6
cerebral cortex17.8
colon9
duodenum8.1
esophagus12.7
gallbladder17.9
heart muscle13.5
kidney9
liver5.4
lung13
lymph node13.4
ovary15.8
pancreas13.1
placenta13.9
prostate15.8
salivary gland15.8
skin10.7
small intestine6.7
spleen13.6
stomach9.5
testis50.4
thyroid gland11.8
urinary bladder16.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609372, gene) Family with sequence similarity 53, member c; FAM53COMIM


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