Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q9NYL2)
Protein (NX_Q9NYL2)
Protein
Gene SymbolZAK to neXtProt (NX_Q9NYL2)
DescriptionMitogen-activated protein kinase kinase kinase MLT
Chromosome2
Location2q31.1 (173940163 ~ 174132738) to Ensembl
Sequene Features : Isoforms 3, Variants 97, PTMs 45 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic process
.intracellular signal transduction
.cell differentiation
  + 11 more...
.poly(A) RNA binding
.ATP binding
.MAP kinase kinase kinase activity
  + 2 more...
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 97 45
2014-09-19protein level
3 83 45
2014-05-27protein level
3 83 45
2014-02-25protein level
3 77 43
2013-12-09protein level
3 55 43
2013-11-01protein level
3 54 42
2013-09-12protein level
3 54 42
2013-08-17protein level
3 54 42
2013-07-15protein level
3 34 42
2013-06-11protein level
3 34 42
2013-02-12protein level
3 21 61
2012-12-20protein level
3 20 61
2012-10-30protein level
3 25 61
2012-10-07protein level
3 25 42
2012-08-24protein level
3 25 42
2012-07-28protein level
3 25 42
2012-06-08protein level
3 31 42
2012-05-07protein level
3 22 42
2012-04-10protein level
3 22 42
2012-01-13protein level
3 14 42
2011-12-20protein level
3 14 42
2011-11-11protein level
3 14 42
2011-08-23protein level
3 14 42
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NYL2-1
26 15 0 91097.3705
NX_Q9NYL2-2
5 15 0 51548.936
NX_Q9NYL2-3
2 14 0 35444.6832
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-602273,EBI-73869 RPS6KA5  
  .interleukin-1-mediated signaling pathway
.stress-activated MAPK cascade
.positive regulation of NF-kappaB transcription factor activity
  + 31 more...
.histone kinase activity (H3-S10 specific)
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
2 EBI-602273,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
3 EBI-687346,EBI-602382 PKN1  
  .regulation of cell motility
.histone H3-T11 phosphorylation
.epithelial cell migration
  + 7 more...
.androgen receptor binding
.Rac GTPase binding
.histone deacetylase binding
  + 10 more...
.cleavage furrow
.midbody
.cytoplasmic membrane-bounded vesicle
  + 6 more...
4 EBI-10255081,EBI-7236323 ZFP2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
5 EBI-10255081,EBI-749400 ZNF567  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland30
ascites150
bladder66
blood49
bone125
bone marrow41
brain43
cervix61
connective tissue73
ear62
embryonic tissue23
esophagus347
eye119
heart167
intestine146
kidney109
larynx85
liver24
lung92
lymph node44
mammary gland59
mouth136
muscle235
nerve64
ovary49
pancreas14
parathyroid145
pharynx49
placenta35
prostate290
skin52
spleen74
stomach219
testis45
thymus12
thyroid150
trachea77
umbilical cord72
uterus168
vascular116
Health State
TissuesTPM*
normal93
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor53
chondrosarcoma144
colorectal tumor106
esophageal tumor115
gastrointestinal tumor143
germ cell tumor68
glioma65
head and neck tumor112
kidney tumor145
leukemia31
liver tumor52
lung tumor184
lymphoma13
non-neoplasia41
ovarian tumor65
pancreatic tumor9
primitive neuroectodermal tumor of the CNS70
prostate cancer38
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor71
uterine tumor88
Developmental Stage
TissuesTPM*
adult102
embryoid body28
blastocyst32
neonate128
fetus107
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue60.8
adrenal gland13.3
appendix24.1
bone marrow4.5
cerebral cortex6.5
colon18.8
duodenum12.7
esophagus57.7
gallbladder37.6
heart muscle166.6
kidney6.9
liver15.3
lung22.2
lymph node10.2
ovary70.3
pancreas5.4
placenta23.7
prostate44.6
salivary gland9.5
skin12.5
small intestine14.9
spleen10.9
stomach9.3
testis13.4
thyroid gland19.9
urinary bladder42.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609479, gene) Leucine zipper- and sterile alpha motif-containing kinaseOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center