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> Protein (NX_Q9NZ81)
Protein (NX_Q9NZ81)
Protein
Gene SymbolPRR13 to neXtProt (NX_Q9NZ81)
DescriptionProline-rich protein 13
Chromosome12
Location12q13.13 (53835389 ~ 53840429) to Ensembl
Sequene Features : Isoforms 2, Variants 12, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 12 0
2014-09-19protein level
2 8 0
2014-05-27transcript level
2 8 0
2014-02-25transcript level
2 7 0
2013-12-09transcript level
2 6 0
2013-11-01transcript level
2 4 0
2013-09-12transcript level
2 4 0
2013-08-17transcript level
2 4 0
2013-07-15transcript level
2 4 0
2013-06-11transcript level
2 4 0
2013-02-12transcript level
2 2 0
2012-12-20transcript level
2 2 0
2012-10-30transcript level
2 2 0
2012-10-07transcript level
2 2 0
2012-08-24transcript level
2 1 0
2012-07-28transcript level
2 1 0
2012-06-08transcript level
2 4 0
2012-05-07transcript level
2 5 0
2012-04-10transcript level
2 5 0
2012-01-13transcript level
2 5 0
2011-12-20transcript level
2 5 0
2011-11-11transcript level
2 5 0
2011-08-23transcript level
2 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NZ81-1
1 1 0 15374.5441
NX_Q9NZ81-2
1 1 0 10524.2509
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740924,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-740924,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
3 EBI-740924,EBI-1049336 TNFAIP8  
  .defense response to Gram-positive bacterium
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
.negative regulation of apoptotic process
.interleukin-1 beta production
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process .cytoplasm
4 EBI-740924,EBI-1170392 LGALS3  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
.negative regulation of immunological synapse formation
  + 19 more...
.poly(A) RNA binding
.laminin binding
.chemoattractant activity
  + 2 more...
.extracellular exosome
.membrane
.external side of plasma membrane
  + 8 more...
5 EBI-740924,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
6 EBI-740924,EBI-750459 SRI  
  .negative regulation of transcription regulatory region DNA binding
.regulation of cell communication by electrical coupling involved in cardiac conduction
.regulation of high voltage-gated calcium channel activity
  + 20 more...
.protein heterodimerization activity
.ion channel binding
.calcium ion binding
  + 4 more...
.extracellular exosome
.dendritic spine neck
.axon terminus
  + 11 more...
7 EBI-740924,EBI-597835 PEX5  
  .negative regulation of protein homotetramerization
.protein tetramerization
.protein import into peroxisome membrane
  + 4 more...
.protein N-terminus binding
.small GTPase binding
.enzyme binding
  + 3 more...
.protein complex
.membrane
.cytosol
  + 6 more...
8 EBI-740924,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
9 EBI-740924,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
10 EBI-740924,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
11 EBI-740924,EBI-355546 PSME3  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.MDM2/MDM4 family protein binding
.endopeptidase activator activity
.identical protein binding
.p53 binding
.membrane
.proteasome activator complex
.cytosol
  + 4 more...
12 EBI-740924,EBI-739737 EWSR1  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.identical protein binding
.zinc ion binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleolus
  + 2 more...
13 EBI-740924,EBI-2107455 VAC14  
  .small molecule metabolic process
.regulation of lipid kinase activity
.viral process
  + 3 more...
.receptor activity .PAS complex
.late endosome membrane
.early endosome membrane
  + 3 more...
14 EBI-740924,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
15 EBI-740924,EBI-10268158 FAM133A  
  .N/A .N/A .N/A
16 EBI-740924,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
17 EBI-740924,EBI-597063 ZCCHC10  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
18 EBI-740924,EBI-742426 SDCBP2  
  .intracellular transport
.intracellular signal transduction
.nervous system development
.protein heterodimerization activity
.protein homodimerization activity
.protein C-terminus binding
.extracellular exosome
.plasma membrane
.cytoplasm
19 EBI-740924,EBI-525456 BAIAP2  
  .positive regulation of actin cytoskeleton reorganization
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.proline-rich region binding
.identical protein binding
.cytoskeletal adaptor activity
.protein C-terminus binding
.extracellular exosome
.neuron projection
.filopodium
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites150
blood89
bone111
bone marrow82
brain40
cervix164
connective tissue67
embryonic tissue84
esophagus148
eye52
heart22
intestine107
kidney33
larynx42
liver116
lung128
lymph270
lymph node66
mammary gland72
mouth15
muscle84
nerve64
ovary88
pancreas168
parathyroid48
pharynx343
placenta70
prostate73
salivary gland148
skin132
spleen18
stomach83
testis64
thymus25
tonsil705
uterus103
Health State
TissuesTPM*
normal57
adrenal tumor158
breast (mammary gland) tumor96
cervical tumor173
chondrosarcoma217
colorectal tumor168
esophageal tumor173
gastrointestinal tumor101
germ cell tumor68
glioma149
head and neck tumor82
kidney tumor58
leukemia116
liver tumor166
lung tumor204
lymphoma207
non-neoplasia10
ovarian tumor39
pancreatic tumor295
primitive neuroectodermal tumor of the CNS55
prostate cancer86
retinoblastoma43
skin tumor199
soft tissue/muscle tissue tumor71
uterine tumor166
Developmental Stage
TissuesTPM*
adult83
embryoid body85
blastocyst113
fetus43
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue64.8
adrenal gland72.1
appendix115.7
bone marrow115.3
cerebral cortex41
colon194.8
duodenum282.7
esophagus55.8
gallbladder113.5
heart muscle39.5
kidney198.8
liver51.7
lung88.5
lymph node130
ovary59
pancreas32.1
placenta71.1
prostate61.1
salivary gland45.3
skin46.2
small intestine276.8
spleen103.8
stomach131.4
testis30.1
thyroid gland89.6
urinary bladder96
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610459, gene) Proline-rich protein 13; PRR13OMIM


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