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> Protein (NX_Q9NZD8)
Protein (NX_Q9NZD8)
Protein
Gene SymbolSPG21 to neXtProt (NX_Q9NZD8)
DescriptionMaspardin
Chromosome15
Location15q22.31 (65255362 ~ 65282648) to Ensembl
Sequene Features : Isoforms 2, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 34 1
2014-09-19protein level
2 27 1
2014-05-27protein level
2 27 1
2014-02-25protein level
2 27 1
2013-12-09protein level
2 23 1
2013-11-01protein level
2 22 1
2013-09-12protein level
2 22 1
2013-08-17protein level
2 22 1
2013-07-15protein level
2 15 1
2013-06-11protein level
2 15 1
2013-02-12protein level
2 2 2
2012-12-20protein level
2 3 2
2012-10-30protein level
2 5 2
2012-10-07protein level
2 5 1
2012-08-24protein level
2 4 1
2012-07-28protein level
2 4 1
2012-06-08protein level
2 8 1
2012-05-07protein level
2 8 1
2012-04-10protein level
2 8 1
2012-01-13protein level
2 7 1
2011-12-20protein level
2 7 1
2011-11-11protein level
2 7 1
2011-08-23protein level
2 7 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NZD8-1
3 14 0 34937.5401
NX_Q9NZD8-2
1 14 0 31564.8739
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742688,EBI-6875961 CRYAA  
  .protein homooligomerization
.response to stimulus
.negative regulation of apoptotic process
  + 2 more...
.unfolded protein binding
.metal ion binding
.identical protein binding
.structural constituent of eye lens
.extracellular exosome
.cytoplasm
.nucleus
2 EBI-742688,EBI-458391 S100B  
  .negative regulation of skeletal muscle cell differentiation
.cellular response to hypoxia
.long-term synaptic potentiation
  + 14 more...
.RAGE receptor binding
.calcium-dependent protein binding
.tau protein binding
  + 5 more...
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.neuronal cell body
  + 5 more...
3 EBI-742688,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
4 EBI-742688,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
5 EBI-742688,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
6 EBI-742688,EBI-749195 PRPS1  
  .hypoxanthine biosynthetic process
.small molecule metabolic process
.urate biosynthetic process
  + 8 more...
.ADP binding
.protein homodimerization activity
.carbohydrate binding
  + 6 more...
.cytosol
.ribose phosphate diphosphokinase complex
7 EBI-742688,EBI-6509505 INCA1  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleus
8 EBI-742688,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
9 EBI-742688,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
10 EBI-742688,EBI-714543 ARL6IP1  
  .cotranslational protein targeting to membrane .N/A .integral component of membrane
.membrane
.cytosol
.Sec61 translocon complex
11 EBI-742688,EBI-2349927 EFHC2  
  .N/A .calcium ion binding .N/A
12 EBI-742688,EBI-741181 AGTRAP  
  .regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
13 EBI-742688,EBI-7082156 SPRED2  
  .regulation of protein deacetylation
.positive regulation of DNA damage response, signal transduction by p53 class mediator
.negative regulation of peptidyl-threonine phosphorylation
  + 2 more...
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.stem cell factor receptor binding
.transport vesicle membrane
.plasma membrane
.cytoplasm
.nucleoplasm
14 EBI-742688,EBI-740376 DTX2  
  .protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.nuclear membrane
.cytoplasm
.nucleoplasm
15 EBI-742688,EBI-2686288 FAM114A1  
  .N/A .N/A .cytoplasm
16 EBI-742688,EBI-1166928 ATPAF2  
  .proton-transporting ATP synthase complex assembly .N/A .nuclear speck
.mitochondrion
17 EBI-742688,EBI-2340392 DTX3L  
  .histone monoubiquitination
.cellular response to DNA damage stimulus
.double-strand break repair
.histone binding
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
.nucleoplasm
.nucleus
18 EBI-742688,EBI-357061 TFG  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.signal transduction
.signal transducer activity .extracellular exosome
.cytoplasm
19 EBI-742688,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
20 EBI-742688,EBI-750345 REEP6  
  .regulation of intracellular transport .N/A .apical part of cell
.rod spherule
.integral component of membrane
  + 2 more...
21 EBI-742688,EBI-722877 TCF12  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of neuron differentiation
.muscle organ development
  + 2 more...
.E-box binding
.protein heterodimerization activity
.SMAD binding
  + 7 more...
.RNA polymerase II transcription factor complex
.cytoplasm
.nucleus
.nuclear chromatin
22 EBI-742688,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
23 EBI-742688,EBI-720828 TRIM9  
  .negative regulation of calcium ion-dependent exocytosis
.proteasome-mediated ubiquitin-dependent protein catabolic process
.negative regulation of SNARE complex assembly
.synaptic vesicle exocytosis
.protein homodimerization activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.dendrite
.cell junction
.synaptic vesicle
  + 2 more...
24 EBI-742688,EBI-740874 CTPS2  
  .nucleobase-containing small molecule metabolic process
.small molecule metabolic process
.'de novo' CTP biosynthetic process
  + 3 more...
.ATP binding
.CTP synthase activity
.cytosol
.mitochondrion
25 EBI-742688,EBI-714918 CUTC  
  .transmembrane transport
.copper ion homeostasis
.protein tetramerization
  + 2 more...
.copper ion binding .cytoplasm
.nucleolus
.nucleoplasm
.nucleus
26 EBI-742688,EBI-712367 RABAC1  
  .N/A .identical protein binding .cell junction
.integral component of membrane
.membrane
  + 3 more...
27 EBI-742688,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
28 EBI-742688,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites50
bladder33
blood49
bone195
bone marrow184
brain61
cervix185
connective tissue53
ear62
embryonic tissue61
esophagus198
eye86
heart78
intestine86
kidney47
larynx340
liver63
lung92
lymph45
lymph node55
mammary gland119
mouth45
muscle47
nerve128
ovary108
pancreas131
parathyroid242
pharynx122
pituitary gland242
placenta158
prostate84
salivary gland49
skin52
stomach52
testis64
thymus37
thyroid515
tonsil58
umbilical cord145
uterus60
vascular38
Health State
TissuesTPM*
normal78
breast (mammary gland) tumor150
cervical tumor260
chondrosarcoma48
colorectal tumor124
esophageal tumor231
gastrointestinal tumor42
germ cell tumor60
glioma65
head and neck tumor283
kidney tumor58
leukemia127
liver tumor83
lung tumor77
lymphoma69
non-neoplasia62
ovarian tumor91
pancreatic tumor104
primitive neuroectodermal tumor of the CNS102
prostate cancer77
retinoblastoma64
skin tumor55
soft tissue/muscle tissue tumor103
uterine tumor33
Developmental Stage
TissuesTPM*
adult116
embryoid body85
blastocyst16
neonate64
fetus77
infant170
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue41
adrenal gland45.4
appendix51.7
bone marrow40.3
cerebral cortex27.1
colon43.3
duodenum48.2
esophagus41.1
gallbladder57.2
heart muscle42.7
kidney59.1
liver44.2
lung53.3
lymph node53.8
ovary51.3
pancreas26.2
placenta65.9
prostate50.5
salivary gland27.6
skin45.7
small intestine42.5
spleen41.5
stomach34.1
testis36.4
thyroid gland81.9
urinary bladder63.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#248900, phenotype) Mast syndromeOMIM
2(*608181, gene) Acidic cluster protein, 33-kdOMIM


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2014-2019 (C) Yonsei Proteome Research Center