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> Protein (NX_Q9NZN8)
Protein (NX_Q9NZN8)
Protein
Gene SymbolCNOT2 to neXtProt (NX_Q9NZN8)
DescriptionCCR4-NOT transcription complex subunit 2
Chromosome12
Location12q15 (70636774 ~ 70748773) to Ensembl
Sequene Features : Isoforms 5, Variants 60, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of stem cell maintenance
.RNA phosphodiester bond hydrolysis, exonucleolytic
.negative regulation of intracellular estrogen receptor signaling pathway
  + 10 more...
.RNA polymerase II transcription corepressor binding
.RNA polymerase II transcription cofactor activity
.CCR4-NOT complex
.membrane
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 60 4
2014-09-19protein level
5 41 4
2014-05-27protein level
5 41 4
2014-02-25protein level
5 39 4
2013-12-09protein level
5 37 4
2013-11-01protein level
5 35 4
2013-09-12protein level
5 35 4
2013-08-17protein level
5 35 4
2013-07-15protein level
5 20 4
2013-06-11protein level
5 20 4
2013-02-12protein level
5 5 12
2012-12-20protein level
5 5 12
2012-10-30protein level
5 5 12
2012-10-07protein level
5 5 4
2012-08-24protein level
5 4 4
2012-07-28protein level
5 4 4
2012-06-08protein level
5 1 4
2012-05-07protein level
5 1 4
2012-04-10protein level
5 1 4
2012-01-13protein level
5 1 4
2011-12-20protein level
5 1 4
2011-11-11protein level
5 1 4
2011-08-23protein level
5 1 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NZN8-1
0 27 0 59699.7637
NX_Q9NZN8-2
0 17 0 40791.8093
NX_Q9NZN8-3
1 7 0 22239.9866
NX_Q9NZN8-4
1 22 0 51503.9675
NX_Q9NZN8-5
1 24 0 54271.1033
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-743033,EBI-1222758 CNOT1  
  .regulation of stem cell maintenance
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
  + 13 more...
.armadillo repeat domain binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 3 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 4 more...
2 EBI-743033,EBI-743073 CNOT3  
  .regulation of stem cell maintenance
.gene silencing by RNA
.gene expression
  + 6 more...
.N/A .CCR4-NOT complex
.cytosol
.nucleus
.cytoplasmic mRNA processing body
3 EBI-743033,EBI-6507625 TNRC6C  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.regulation of gene silencing by miRNA
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 13 more...
.RNA binding
.nucleotide binding
.cytosol
4 EBI-743033,EBI-742299 CNOT8  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of mRNA catabolic process
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
  + 9 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.RNA binding
  + 2 more...
.CCR4-NOT complex
.cytosol
.nucleus
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder100
blood16
bone69
bone marrow20
brain2
cervix20
connective tissue93
ear248
embryonic tissue131
esophagus99
eye4
heart167
intestine4
kidney9
larynx85
liver9
lung2
lymph112
lymph node89
mammary gland92
mouth30
muscle18
nerve64
ovary9
pancreas159
parathyroid145
pharynx24
pituitary gland181
placenta3
prostate84
salivary gland49
skin56
spleen74
stomach73
testis13
thymus37
thyroid21
tonsil58
trachea38
umbilical cord72
uterus90
vascular58
Health State
TissuesTPM*
normal6
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor75
cervical tumor28
chondrosarcoma72
colorectal tumor79
esophageal tumor57
gastrointestinal tumor8
germ cell tumor15
glioma102
head and neck tumor7
kidney tumor14
leukemia21
liver tumor124
lung tumor9
lymphoma13
non-neoplasia62
ovarian tumor144
pancreatic tumor95
primitive neuroectodermal tumor of the CNS149
prostate cancer77
retinoblastoma21
skin tumor47
soft tissue/muscle tissue tumor15
uterine tumor110
Developmental Stage
TissuesTPM*
adult3
embryoid body42
blastocyst97
neonate32
fetus8
infant127
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.1
adrenal gland27.5
appendix34
bone marrow55
cerebral cortex29.1
colon34.5
duodenum33
esophagus56.9
gallbladder58.2
heart muscle25.5
kidney24.6
liver23
lung38.2
lymph node46.3
ovary39.9
pancreas11
placenta34.4
prostate26.3
salivary gland18.7
skin61.8
small intestine30.9
spleen36.2
stomach25.5
testis29.1
thyroid gland52.1
urinary bladder43.5
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*604909, gene) Ccr4-not transcription complex, subunit 2; CNOT2OMIM


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