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> Protein (NX_Q9NZV5)
Protein (NX_Q9NZV5)
Protein
Gene SymbolSEPN1 to neXtProt (NX_Q9NZV5)
DescriptionSelenoprotein N
Chromosome1
Location1p36.11 (26126667 ~ 26144713) to Ensembl
Sequene Features : Isoforms 2, Variants 70, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .calcium ion binding .endoplasmic reticulum membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 70 7
2014-09-19protein level
2 57 7
2014-05-27protein level
2 57 7
2014-02-25protein level
2 57 7
2013-12-09protein level
2 43 7
2013-11-01protein level
2 42 7
2013-09-12protein level
2 42 7
2013-08-17protein level
2 42 7
2013-07-15protein level
2 26 7
2013-06-11protein level
2 26 7
2013-02-12protein level
2 20 12
2012-12-20protein level
2 20 12
2012-10-30protein level
2 23 12
2012-10-07protein level
2 23 7
2012-08-24protein level
2 22 7
2012-07-28protein level
2 22 7
2012-06-08protein level
2 24 7
2012-05-07protein level
2 20 7
2012-04-10protein level
2 20 7
2012-01-13protein level
2 22 7
2011-12-20protein level
2 22 7
2011-11-11protein level
2 22 7
2011-08-23protein level
2 22 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9NZV5-1
2 20 0 65434.7516
NX_Q9NZV5-2
1 20 0 61826.029
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1751965,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites75
bone153
brain42
cervix61
connective tissue13
embryonic tissue145
esophagus99
eye57
heart100
intestine51
kidney14
larynx42
liver9
lung80
lymph node11
mammary gland59
mouth45
muscle84
nerve128
ovary177
pancreas84
parathyroid145
pituitary gland60
placenta52
prostate100
salivary gland49
skin223
spleen74
stomach52
testis39
thyroid128
trachea19
umbilical cord726
uterus38
vascular96
Health State
TissuesTPM*
normal54
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor86
chondrosarcoma120
colorectal tumor35
esophageal tumor115
gastrointestinal tumor101
germ cell tumor72
glioma121
head and neck tumor74
liver tumor20
lung tumor77
lymphoma13
non-neoplasia10
ovarian tumor196
pancreatic tumor152
primitive neuroectodermal tumor of the CNS7
prostate cancer105
retinoblastoma64
skin tumor247
soft tissue/muscle tissue tumor87
uterine tumor55
Developmental Stage
TissuesTPM*
adult75
embryoid body171
blastocyst162
neonate225
fetus53
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue235.7
adrenal gland265.1
appendix200.7
bone marrow284.8
cerebral cortex690.5
colon563.9
duodenum23
esophagus25.3
gallbladder993.8
heart muscle29
kidney120.2
liver75.4
lung47.9
lymph node367
ovary38.9
pancreas782.8
placenta81.5
prostate96.4
salivary gland27.4
skin84.7
small intestine48.4
spleen45.3
stomach21.6
testis18.1
thyroid gland42.2
urinary bladder294.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastLow
cerebellumMedium
cerebral cortexLow
cervix, uterineHigh
colonHigh
duodenumHigh
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderMedium
hippocampusLow
kidneyMedium
liverLow
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
pancreasHigh
placentaMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skin 1Medium
skin 2High
small intestineHigh
soft tissue 1Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#602771, phenotype) Rigid spine muscular dystrophy 1; RSMD1OMIM
2(*606210, gene) Selenoprotein n, 1; SEPN1OMIM


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