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> Protein (NX_Q9P0K1)
Protein (NX_Q9P0K1)
Protein
Gene SymbolADAM22 to neXtProt (NX_Q9P0K1)
DescriptionDisintegrin and metalloproteinase domain-containing protein 22
Chromosome7
Location7q21.12 (87563458 ~ 87832204) to Ensembl
Sequene Features : Isoforms 5, Variants 137, PTMs 25 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.myelination in peripheral nervous system
.adult locomotory behavior
.central nervous system development
  + 2 more...
.zinc ion binding
.integrin binding
.metalloendopeptidase activity
.axon
.integral component of membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 137 25
2014-09-19protein level
5 92 25
2014-05-27protein level
5 92 25
2014-02-25protein level
5 91 25
2013-12-09protein level
5 69 25
2013-11-01protein level
5 67 25
2013-09-12protein level
5 67 27
2013-08-17protein level
5 67 27
2013-07-15protein level
5 48 27
2013-06-11protein level
5 48 27
2013-02-12protein level
5 18 137
2012-12-20protein level
5 15 137
2012-10-30protein level
5 26 137
2012-10-07protein level
5 26 29
2012-08-24protein level
5 23 29
2012-07-28protein level
5 23 29
2012-06-08protein level
5 26 29
2012-05-07protein level
5 19 29
2012-04-10protein level
5 19 29
2012-01-13protein level
5 11 29
2011-12-20protein level
5 11 29
2011-11-11protein level
5 11 29
2011-08-23protein level
5 11 29
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9P0K1-1
0 43 0 100367.6753
NX_Q9P0K1-2
2 40 0 100203.6057
NX_Q9P0K1-3
0 40 0 95226.0656
NX_Q9P0K1-4
0 38 0 91432.2215
NX_Q9P0K1-5
0 41 0 96573.8312
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1567267,EBI-359854 YWHAQ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 8 more...
.protein N-terminus binding .extracellular exosome
.protein complex
.cytoplasmic vesicle membrane
  + 4 more...
2 EBI-1567267,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
3 EBI-1567267,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bone55
brain47
connective tissue6
ear62
embryonic tissue4
eye33
heart33
intestine8
kidney42
liver4
lung14
mammary gland6
muscle56
nerve128
pancreas4
pharynx24
pituitary gland242
prostate15
skin9
testis6
uterus4
Health State
TissuesTPM*
normal26
adrenal tumor158
breast (mammary gland) tumor10
chondrosarcoma48
germ cell tumor11
glioma9
head and neck tumor22
kidney tumor29
lung tumor19
non-neoplasia51
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer9
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult21
blastocyst16
fetus34
infant85
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.8
adrenal gland9.4
appendix1
cerebral cortex26.4
colon1.9
gallbladder2.8
heart muscle1.6
kidney3.4
lung1.1
lymph node2.1
ovary3.8
prostate7.3
spleen1.6
testis2
thyroid gland4
urinary bladder2.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603709, gene) A disintegrin and metalloproteinase domain 22; ADAM22OMIM


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