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> Protein (NX_Q9P0L0)
Protein (NX_Q9P0L0)
Protein
Gene SymbolVAPA to neXtProt (NX_Q9P0L0)
DescriptionVesicle-associated membrane protein-associated protein A
Chromosome18
Location18p11.22 (9913999 ~ 9960018) to Ensembl
Sequene Features : Isoforms 2, Variants 44, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.COPII-coated vesicle budding
.protein localization to endoplasmic reticulum
.membrane fusion
  + 11 more...
.protein heterodimerization activity
.FFAT motif binding
.protein domain specific binding
  + 2 more...
.vesicle
.integral component of membrane
.microtubule cytoskeleton
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 44 10
2014-09-19protein level
2 35 10
2014-05-27protein level
2 35 10
2014-02-25protein level
2 35 10
2013-12-09protein level
2 21 10
2013-11-01protein level
2 21 8
2013-09-12protein level
2 21 8
2013-08-17protein level
2 21 8
2013-07-15protein level
2 8 6
2013-06-11protein level
2 8 6
2013-02-12protein level
2 8 4
2012-12-20protein level
2 9 4
2012-10-30protein level
2 14 4
2012-10-07protein level
2 14 2
2012-08-24protein level
2 13 2
2012-07-28protein level
2 13 2
2012-06-08protein level
2 17 2
2012-05-07protein level
2 16 2
2012-04-10protein level
2 16 2
2012-01-13protein level
2 19 2
2011-12-20protein level
2 19 2
2011-11-11protein level
2 19 2
2011-08-23protein level
2 19 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9P0L0-1
1 10 1 27875.13
NX_Q9P0L0-2
1 10 1 32592.5297
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1059156,EBI-9350848 VAPB  
  .COPII-coated vesicle budding
.negative regulation by virus of viral protein levels in host cell
.positive regulation of viral genome replication
  + 13 more...
.beta-tubulin binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.integral component of membrane
.Golgi apparatus
.endoplasmic reticulum membrane
  + 2 more...
2 EBI-1059156,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-1059156,EBI-2624570 OPRM1  
  .regulation of N-methyl-D-aspartate selective glutamate receptor activity
.cellular response to morphine
.response to growth factor
  + 30 more...
.neuropeptide binding
.morphine receptor activity
.G-protein beta-subunit binding
  + 4 more...
.membrane raft
.perikaryon
.neuron projection
  + 8 more...
4 EBI-1059156,EBI-9819369 STARD3  
  .cholesterol metabolic process
.steroid metabolic process
.mitochondrial transport
  + 2 more...
.cholesterol transporter activity
.cholesterol binding
.late endosome membrane
.integral component of membrane
.lysosomal membrane
  + 2 more...
5 EBI-1059156,EBI-3892947 ZFYVE27  
  .protein localization to plasma membrane
.neurotrophin TRK receptor signaling pathway
.neuron projection development
.metal ion binding .endoplasmic reticulum tubular network
.recycling endosome membrane
.growth cone membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland121
ascites25
bladder167
blood81
bone195
bone marrow123
brain169
cervix123
connective tissue248
ear186
embryonic tissue192
esophagus99
eye167
heart67
intestine116
kidney113
larynx85
liver126
lung149
lymph45
lymph node144
mammary gland92
muscle112
nerve257
ovary216
pancreas149
parathyroid48
pharynx98
pituitary gland302
placenta166
prostate121
salivary gland98
skin104
spleen37
stomach125
testis133
thymus125
thyroid85
tonsil58
trachea154
uterus172
vascular58
Health State
TissuesTPM*
normal144
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor53
cervical tumor173
chondrosarcoma181
colorectal tumor133
esophageal tumor115
gastrointestinal tumor109
germ cell tumor87
glioma130
head and neck tumor52
kidney tumor101
leukemia52
liver tumor72
lung tumor155
lymphoma69
non-neoplasia82
ovarian tumor262
pancreatic tumor142
primitive neuroectodermal tumor of the CNS70
prostate cancer182
retinoblastoma86
skin tumor111
soft tissue/muscle tissue tumor359
uterine tumor188
Developmental Stage
TissuesTPM*
adult145
embryoid body185
blastocyst113
neonate64
fetus154
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue83.8
adrenal gland184
appendix84
bone marrow137.6
cerebral cortex106.1
colon124.4
duodenum96.6
esophagus131
gallbladder130.5
heart muscle124.8
kidney103
liver77.8
lung96
lymph node86.2
ovary118.8
pancreas62.2
placenta112.8
prostate84.8
salivary gland78.3
skin72.2
small intestine98.6
spleen74.2
stomach99.6
testis77.2
thyroid gland148.7
urinary bladder125.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Low
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605703, gene) Vesicle-associated membrane protein-associated protein a; VAPAOMIM


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