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> Protein (NX_Q9P0N8)
Protein (NX_Q9P0N8)
Protein
Gene SymbolMARCH2 to neXtProt (NX_Q9P0N8)
DescriptionE3 ubiquitin-protein ligase MARCH2
Chromosome19
Location19p13.2 (8478154 ~ 8503901) to Ensembl
Sequene Features : Isoforms 2, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein ubiquitination
.endocytosis
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasmic vesicle
.integral component of membrane
.endosome membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 36 0
2014-09-19protein level
2 27 0
2014-05-27protein level
2 27 0
2014-02-25protein level
2 26 0
2013-12-09protein level
2 15 0
2013-11-01protein level
2 13 0
2013-09-12protein level
2 13 0
2013-08-17protein level
2 13 0
2013-07-15protein level
2 10 0
2013-06-11protein level
2 10 0
2013-02-12protein level
2 8 0
2012-12-20protein level
2 8 0
2012-10-30protein level
2 10 0
2012-10-07protein level
2 10 0
2012-08-24protein level
2 10 0
2012-07-28protein level
2 10 0
2012-06-08protein level
2 11 0
2012-05-07protein level
2 7 0
2012-04-10protein level
2 7 0
2012-01-13protein level
2 4 0
2011-12-20protein level
2 4 0
2011-11-11protein level
2 4 0
2011-08-23protein level
2 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9P0N8-1
3 7 0 26977.4115
NX_Q9P0N8-2
1 7 0 19086.2355
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10317612,EBI-10173166 LDLRAD1  
  .N/A .N/A .integral component of membrane
2 EBI-10317612,EBI-7131783 SYNE4  
  .establishment of epithelial cell apical/basal polarity .N/A .LINC complex
.integral component of nuclear outer membrane
3 EBI-10317612,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
4 EBI-10317612,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone27
bone marrow20
brain12
connective tissue20
embryonic tissue4
eye14
heart11
intestine12
kidney4
liver4
lung20
lymph67
mammary gland6
pancreas4
parathyroid48
pharynx24
pituitary gland60
placenta7
prostate26
skin33
testis39
thyroid64
uterus8
Health State
TissuesTPM*
normal11
breast (mammary gland) tumor10
chondrosarcoma60
glioma27
head and neck tumor22
leukemia10
lung tumor9
lymphoma41
non-neoplasia10
pancreatic tumor9
prostate cancer28
skin tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult10
embryoid body14
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue45.6
adrenal gland14.3
appendix19.5
bone marrow16.6
cerebral cortex20.9
colon17.3
duodenum14.9
esophagus22.9
gallbladder14.6
heart muscle40.8
kidney15.3
liver11.1
lung24
lymph node17.3
ovary5.9
pancreas8.6
placenta15.3
prostate23.9
salivary gland13.3
skin13.1
small intestine14.1
spleen24.1
stomach16.5
testis13
thyroid gland28.9
urinary bladder29.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*613332, gene) Membrane-associated ring-ch finger protein 2; MARCH2OMIM


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