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> Protein (NX_Q9P0N9)
Protein (NX_Q9P0N9)
Protein
Gene SymbolTBC1D7 to neXtProt (NX_Q9P0N9)
DescriptionTBC1 domain family member 7
Chromosome6
Location6p24.1 (13266774 ~ 13328815) to Ensembl
Sequene Features : Isoforms 4, Variants 49, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cilium assembly
.activation of GTPase activity
.response to growth factor
  + 2 more...
.Rab GTPase binding
.GTPase activator activity
.ciliary basal body
.cytoplasmic vesicle
.cytoplasmic membrane-bounded vesicle
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 49 3
2014-09-19protein level
4 41 3
2014-05-27protein level
4 41 3
2014-02-25protein level
4 41 3
2013-12-09protein level
4 28 3
2013-11-01protein level
4 27 2
2013-09-12protein level
4 27 2
2013-08-17protein level
4 27 2
2013-07-15protein level
4 21 0
2013-06-11protein level
4 21 0
2013-02-12protein level
4 10 0
2012-12-20protein level
3 9 0
2012-10-30protein level
3 14 0
2012-10-07protein level
3 14 0
2012-08-24protein level
2 12 0
2012-07-28protein level
2 11 0
2012-06-08protein level
2 11 0
2012-05-07protein level
2 12 0
2012-04-10protein level
2 12 0
2012-01-13protein level
2 6 0
2011-12-20protein level
2 6 0
2011-11-11protein level
2 6 0
2011-08-23protein level
2 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9P0N9-1
0 16 0 33949.4174
NX_Q9P0N9-2
1 14 0 30726.7179
NX_Q9P0N9-3
0 14 0 26769.6866
NX_Q9P0N9-4
1 12 0 28490.8011
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3258000,EBI-2515299 SSNA1  
  .ciliary receptor clustering involved in smoothened signaling pathway
.intraciliary transport
.organelle organization
  + 2 more...
.N/A .ciliary basal body
.cytosol
.centrosome
.nucleus
2 EBI-3258000,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
3 EBI-3258000,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
4 EBI-3258000,EBI-1050213 RPGRIP1  
  .retina development in camera-type eye
.response to stimulus
.eye photoreceptor cell development
.visual perception
.N/A .photoreceptor connecting cilium
.axoneme
5 EBI-3258000,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
6 EBI-3258000,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
7 EBI-3258000,EBI-2548012 BLZF1  
  .Golgi to plasma membrane protein transport
.cell proliferation
.Golgi organization
  + 3 more...
.ubiquitin protein ligase binding
.enzyme binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.Golgi lumen
.cytoplasm
.nucleoplasm
  + 2 more...
8 EBI-3258000,EBI-746704 HOOK1  
  .early endosome to late endosome transport
.protein transport
.endosome to lysosome transport
  + 4 more...
.identical protein binding .FHF complex
.microtubule
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
blood40
bone41
bone marrow20
brain24
connective tissue6
embryonic tissue9
eye28
heart22
intestine12
kidney37
liver14
lung11
lymph node55
mammary gland39
ovary9
pancreas9
placenta28
prostate15
salivary gland98
skin156
stomach10
testis22
thymus37
thyroid21
trachea38
uterus4
Health State
TissuesTPM*
normal28
breast (mammary gland) tumor53
chondrosarcoma36
gastrointestinal tumor25
germ cell tumor26
glioma37
head and neck tumor22
kidney tumor14
leukemia42
liver tumor10
lymphoma55
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
retinoblastoma43
skin tumor223
uterine tumor11
Developmental Stage
TissuesTPM*
adult15
embryoid body14
fetus57
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.6
adrenal gland9.3
appendix10.1
bone marrow16.9
cerebral cortex11.3
colon14.3
duodenum13.3
esophagus12.1
gallbladder10.8
heart muscle26.6
kidney16.5
liver7.5
lung7.7
lymph node12.8
ovary4
pancreas4
placenta12.6
prostate12
salivary gland6.4
skin10.1
small intestine10.4
spleen8.6
stomach8.4
testis14.6
thyroid gland7.8
urinary bladder12.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(-248000, phenotype) MacrocephalyOMIM
2(*612655, gene) Tbc1 domain family, member 7; TBC1D7OMIM


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