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> Protein (NX_Q9P0T4)
Protein (NX_Q9P0T4)
Protein
Gene SymbolZNF581 to neXtProt (NX_Q9P0T4)
DescriptionZinc finger protein 581
Chromosome19
Location19q13.42 (56146825 ~ 56156988) to Ensembl
Sequene Features : Isoforms 1, Variants 18, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 18 0
2014-09-19protein level
1 13 0
2014-05-27protein level
1 13 0
2014-02-25protein level
1 13 0
2013-12-09protein level
1 10 0
2013-11-01protein level
1 9 0
2013-09-12protein level
1 9 0
2013-08-17protein level
1 9 0
2013-07-15transcript level
1 8 0
2013-06-11transcript level
1 8 0
2013-02-12transcript level
1 3 0
2012-12-20transcript level
1 3 0
2012-10-30transcript level
1 3 0
2012-10-07transcript level
1 3 0
2012-08-24transcript level
1 3 0
2012-07-28transcript level
1 3 0
2012-06-08transcript level
1 3 0
2012-05-07transcript level
1 1 0
2012-04-10transcript level
1 1 0
2012-01-13transcript level
1 2 0
2011-12-20transcript level
1 2 0
2011-11-11transcript level
1 2 0
2011-08-23transcript level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9P0T4-1
10 0 0 21995.6686
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-745520,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-745520,EBI-748961 CCNDBP1  
  .regulation of cell cycle
.cell cycle
.N/A .cytoplasm
.nucleoplasm
.nucleus
3 EBI-745520,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
4 EBI-745520,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
5 EBI-745520,EBI-3505701 SOX5  
  .positive regulation of mesenchymal stem cell differentiation
.cellular response to transforming growth factor beta stimulus
.positive regulation of cartilage development
  + 10 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nuclear transcription factor complex
6 EBI-745520,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
7 EBI-745520,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
8 EBI-745520,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
9 EBI-745520,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
10 EBI-745520,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
11 EBI-745520,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
12 EBI-745520,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
13 EBI-745520,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
14 EBI-745520,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
15 EBI-745520,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
16 EBI-745520,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
17 EBI-745520,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
18 EBI-745520,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
19 EBI-745520,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
20 EBI-745520,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
21 EBI-745520,EBI-10174653 DOCK8  
  .negative regulation of T cell apoptotic process
.memory T cell proliferation
.dendritic cell migration
  + 3 more...
.guanyl-nucleotide exchange factor activity .cell leading edge
.membrane
.cytosol
22 EBI-745520,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
23 EBI-745520,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
24 EBI-745520,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
25 EBI-745520,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
26 EBI-745520,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
27 EBI-745520,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
28 EBI-745520,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
29 EBI-745520,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
30 EBI-745520,EBI-742426 SDCBP2  
  .intracellular transport
.intracellular signal transduction
.nervous system development
.protein heterodimerization activity
.protein homodimerization activity
.protein C-terminus binding
.extracellular exosome
.plasma membrane
.cytoplasm
31 EBI-745520,EBI-349832 GOPC  
  .protein homooligomerization
.regulation of catalytic activity
.apical protein localization
  + 6 more...
.ion channel binding .postsynaptic membrane
.protein complex
.Golgi-associated vesicle membrane
  + 9 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
blood57
bone69
bone marrow20
brain8
cervix20
connective tissue6
embryonic tissue46
eye28
heart33
intestine21
kidney23
liver24
lung14
lymph node66
mammary gland6
muscle37
pancreas14
placenta3
salivary gland49
skin37
stomach20
testis2
tonsil117
umbilical cord145
uterus21
vascular38
Health State
TissuesTPM*
normal19
cervical tumor28
chondrosarcoma60
colorectal tumor17
gastrointestinal tumor16
germ cell tumor7
glioma27
head and neck tumor7
kidney tumor58
leukemia21
liver tumor41
lung tumor38
lymphoma69
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
skin tumor47
soft tissue/muscle tissue tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult11
embryoid body85
blastocyst16
neonate64
fetus23
infant85
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.1
adrenal gland6.3
appendix8.4
bone marrow9.7
cerebral cortex2.8
colon6.4
duodenum6.7
esophagus5.4
gallbladder7
heart muscle3.2
kidney6.4
liver2.7
lung6.3
lymph node13
ovary15.9
pancreas6.2
placenta6.3
prostate5.5
salivary gland7.2
skin8.8
small intestine7
spleen12.5
stomach8.4
testis5.7
thyroid gland5.8
urinary bladder7.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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