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> Protein (NX_Q9P0U4)
Protein (NX_Q9P0U4)
Protein
Gene SymbolCXXC1 to neXtProt (NX_Q9P0U4)
DescriptionCXXC-type zinc finger protein 1
Chromosome18
Location18q21.1 (47808713 ~ 47814674) to Ensembl
Sequene Features : Isoforms 2, Variants 66, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H3-K4 methylation
.positive regulation of transcription, DNA-templated
.cellular protein metabolic process
  + 4 more...
.unmethylated CpG binding
.zinc ion binding
.Set1C/COMPASS complex
.histone methyltransferase complex
.nuclear speck
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 66 5
2014-09-19protein level
2 41 5
2014-05-27protein level
2 41 5
2014-02-25protein level
2 41 5
2013-12-09protein level
2 38 5
2013-11-01protein level
2 36 5
2013-09-12protein level
2 36 5
2013-08-17protein level
2 36 5
2013-07-15protein level
2 28 4
2013-06-11protein level
2 28 4
2013-02-12protein level
2 11 8
2012-12-20protein level
2 10 8
2012-10-30protein level
2 11 8
2012-10-07protein level
2 11 4
2012-08-24protein level
2 3 4
2012-07-28protein level
2 3 4
2012-06-08protein level
2 9 4
2012-05-07protein level
2 9 4
2012-04-10protein level
2 9 4
2012-01-13protein level
2 11 4
2011-12-20protein level
2 9 4
2011-11-11protein level
2 9 4
2011-08-23protein level
2 9 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9P0U4-1
0 25 0 75662.9585
NX_Q9P0U4-2
0 25 0 76178.2096
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-949911,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-949911,EBI-592823 RBBP5  
  .histone H3-K4 methylation
.response to estrogen
.cellular response to DNA damage stimulus
  + 3 more...
.transcription regulatory region DNA binding
.methylated histone binding
.MLL1 complex
.Set1C/COMPASS complex
.histone methyltransferase complex
  + 3 more...
3 EBI-949911,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
blood114
bone27
bone marrow20
brain45
cervix103
connective tissue33
embryonic tissue51
eye71
heart22
intestine60
kidney14
larynx213
liver14
lung32
lymph158
lymph node111
mammary gland52
muscle75
nerve193
ovary59
pancreas37
parathyroid97
placenta42
prostate31
skin47
spleen56
stomach62
testis112
thymus37
thyroid21
uterus64
Health State
TissuesTPM*
normal40
breast (mammary gland) tumor85
cervical tumor28
chondrosarcoma36
colorectal tumor97
gastrointestinal tumor75
germ cell tumor37
glioma74
head and neck tumor44
kidney tumor29
leukemia137
liver tumor10
lung tumor68
lymphoma166
non-neoplasia31
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer28
retinoblastoma64
skin tumor63
soft tissue/muscle tissue tumor127
uterine tumor66
Developmental Stage
TissuesTPM*
adult62
embryoid body42
blastocyst65
fetus35
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.6
adrenal gland31.3
appendix43.7
bone marrow87.7
cerebral cortex26.8
colon28.7
duodenum39.8
esophagus27
gallbladder33.6
heart muscle22.3
kidney29
liver12.6
lung36.2
lymph node70.9
ovary46.7
pancreas32.6
placenta31.9
prostate34.1
salivary gland43
skin66.8
small intestine38.6
spleen63.3
stomach43.4
testis41.8
thyroid gland34.7
urinary bladder37.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609150, gene) Cxxc finger protein 1; CXXC1OMIM


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