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Protein |
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Gene Symbol | DLGAP2 to neXtProt (NX_Q9P1A6) |
Description | Disks large-associated protein 2 |
Chromosome | 8 |
Location | 8p23.3 (1449532 ~ 1656642) to Ensembl |
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Sequene Features : Isoforms 3, Variants 177, PTMs 1 to neXtProt Sequence Features
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Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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.neuron-neuron synaptic transmission |
.N/A |
.postsynaptic membrane .cell junction .postsynaptic density .neurofilament |
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Proteomic Evidences |
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Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
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2015-01-01 | | protein level | | | | | | | 3 |
| 177 |
| 1 |
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2014-09-19 | | protein level | | | | | | | 3 |
| 134 |
| 1 |
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2014-05-27 | | protein level | | | | | | | 3 |
| 134 |
| 1 |
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2014-02-25 | | protein level | | | | | | | 3 |
| 132 |
| 1 |
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2013-12-09 | | protein level | | | | | | | 3 |
| 108 |
| 1 |
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2013-11-01 | | protein level | | | | | | | 3 |
| 107 |
| 1 |
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2013-09-12 | | protein level | | | | | | | 3 |
| 107 |
| 10 |
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2013-08-17 | | protein level | | | | | | | 3 |
| 107 |
| 10 |
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2013-07-15 | | protein level | | | | | | | 3 |
| 73 |
| 10 |
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2013-06-11 | | protein level | | | | | | | 3 |
| 73 |
| 10 |
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2013-02-12 | | protein level | | | | | | | 3 |
| 22 |
| 30 |
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2012-12-20 | | protein level | | | | | | | 3 |
| 22 |
| 30 |
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2012-10-30 | | protein level | | | | | | | 3 |
| 28 |
| 30 |
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2012-10-07 | | protein level | | | | | | | 3 |
| 28 |
| 10 |
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2012-08-24 | | protein level | | | | | | | 3 |
| 24 |
| 10 |
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2012-07-28 | | protein level | | | | | | | 3 |
| 24 |
| 10 |
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2012-06-08 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
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2012-05-07 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
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2012-04-10 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
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2012-01-13 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
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2011-12-20 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
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2011-11-11 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
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2011-08-23 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
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Protein Isoforms |
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| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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Interacting Partners |
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No. |
Exp. ref. |
Symbol |
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PE |
Pr |
Ab |
Di |
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GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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1 |
EBI-1753397,EBI-389883 |
NCK1 |
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.negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation .negative regulation of PERK-mediated unfolded protein response + 23 more... |
.eukaryotic initiation factor eIF2 binding .receptor tyrosine kinase binding .protein binding, bridging + 5 more... |
.vesicle membrane .cell-cell junction .plasma membrane + 6 more... |
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2 |
EBI-1753397,EBI-401755 |
GRB2 |
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| | | | |
.positive regulation of reactive oxygen species metabolic process .cellular response to ionizing radiation .branching involved in labyrinthine layer morphogenesis + 25 more... |
.ephrin receptor binding .poly(A) RNA binding .insulin receptor substrate binding + 6 more... |
.Grb2-EGFR complex .extracellular exosome .vesicle membrane + 10 more... |
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3 |
EBI-1753397,EBI-10171697 |
KRT40 |
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.N/A |
.structural molecule activity |
.intermediate filament |
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4 |
EBI-1753397,EBI-10172511 |
KRTAP4-2 |
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.N/A |
.N/A |
.keratin filament |
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EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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Body Sites | |
Tissues | TPM* | |
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blood | 8 | |
brain | 6 | |
kidney | 4 | |
lung | 8 | |
mouth | 45 | |
testis | 18 | |
uterus | 4 | |
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Health State | |
Tissues | TPM* | |
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normal | 7 | |
germ cell tumor | 15 | |
head and neck tumor | 22 | |
leukemia | 10 | |
lung tumor | 9 | |
soft tissue/muscle tissue tumor | 7 | |
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Developmental Stage | |
Tissues | TPM* | |
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adult | 5 | |
fetus | 16 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
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Expression level of Protein (ref. Human Protein Atlas) |
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RNA-Seq. | |
Tissues | FPKM | |
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cerebral cortex | 3.2 | |
kidney | 2.1 | |
testis | 8.4 | |
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Cancer | |
Tumor | Number of patients and Staining levels | |
breast cancer | |
carcinoid | |
cervical cancer | |
colorectal cancer | |
endometrial cancer | |
glioma | |
head and neck cancer | |
liver cancer | |
lung cancer | |
lymphoma | |
melanoma | |
ovarian cancer | |
pancreatic cancer | |
prostate cancer | |
renal cancer | |
skin cancer | |
stomach cancer | |
testis cancer | |
thyroid cancer | |
urothelial cancer | |
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RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) |
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Moderately expressed RNAs (50> FPKM >10) |
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Lower expressed RNAs (10> FPKM >1) |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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Staining level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Not Detected |
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Disease |
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No. | Disease Description | Ref. |
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1 | (*605438, gene) Discs large-associated protein 2; DLGAP2 | OMIM |
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