|
| Protein |
|
| Gene Symbol | DLGAP2 to neXtProt (NX_Q9P1A6) |
| Description | Disks large-associated protein 2 |
| Chromosome | 8 |
| Location | 8p23.3 (1449532 ~ 1656642) to Ensembl |
|
|
Sequene Features : Isoforms 3, Variants 177, PTMs 1 to neXtProt Sequence Features
|
|
Gene
Ontologies |
| GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
|
.neuron-neuron synaptic transmission |
.N/A |
.postsynaptic membrane
.cell junction
.postsynaptic density
.neurofilament |
|
|
| |
|
| Proteomic Evidences |
|
| |
|
| Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
|
| 2015-01-01 | | protein level | | | | | | | 3 |
| 177 |
| 1 |
|
| 2014-09-19 | | protein level | | | | | | | 3 |
| 134 |
| 1 |
|
| 2014-05-27 | | protein level | | | | | | | 3 |
| 134 |
| 1 |
|
| 2014-02-25 | | protein level | | | | | | | 3 |
| 132 |
| 1 |
|
| 2013-12-09 | | protein level | | | | | | | 3 |
| 108 |
| 1 |
|
| 2013-11-01 | | protein level | | | | | | | 3 |
| 107 |
| 1 |
|
| 2013-09-12 | | protein level | | | | | | | 3 |
| 107 |
| 10 |
|
| 2013-08-17 | | protein level | | | | | | | 3 |
| 107 |
| 10 |
|
| 2013-07-15 | | protein level | | | | | | | 3 |
| 73 |
| 10 |
|
| 2013-06-11 | | protein level | | | | | | | 3 |
| 73 |
| 10 |
|
| 2013-02-12 | | protein level | | | | | | | 3 |
| 22 |
| 30 |
|
| 2012-12-20 | | protein level | | | | | | | 3 |
| 22 |
| 30 |
|
| 2012-10-30 | | protein level | | | | | | | 3 |
| 28 |
| 30 |
|
| 2012-10-07 | | protein level | | | | | | | 3 |
| 28 |
| 10 |
|
| 2012-08-24 | | protein level | | | | | | | 3 |
| 24 |
| 10 |
|
| 2012-07-28 | | protein level | | | | | | | 3 |
| 24 |
| 10 |
|
| 2012-06-08 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
|
| 2012-05-07 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
|
| 2012-04-10 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
|
| 2012-01-13 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
|
| 2011-12-20 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
|
| 2011-11-11 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
|
| 2011-08-23 | | protein level | | | | | | | 3 |
| 3 |
| 10 |
|
|
| |
|
| Protein Isoforms |
|
| |
| |
|
| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
|
|
| |
|
| Interacting Partners |
|
| |
|
| No. |
Exp. ref. |
Symbol |
|
PE |
Pr |
Ab |
Di |
|
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
|
| 1 |
EBI-1753397,EBI-389883 |
NCK1 |
|
| | | | |
.negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
+ 23 more... |
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
+ 5 more... |
.vesicle membrane
.cell-cell junction
.plasma membrane
+ 6 more... |
|
| 2 |
EBI-1753397,EBI-401755 |
GRB2 |
|
| | | | |
.positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
+ 25 more... |
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
+ 6 more... |
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
+ 10 more... |
|
| 3 |
EBI-1753397,EBI-10171697 |
KRT40 |
|
| | | | |
.N/A |
.structural molecule activity |
.intermediate filament |
|
| 4 |
EBI-1753397,EBI-10172511 |
KRTAP4-2 |
|
| | | | |
.N/A |
.N/A |
.keratin filament |
|
|
| |
|
| EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
|
| |
|
| Body Sites | |
| Tissues | TPM* | |
|
| blood | 8 | |
| brain | 6 | |
| kidney | 4 | |
| lung | 8 | |
| mouth | 45 | |
| testis | 18 | |
| uterus | 4 | |
|
| Health State | |
| Tissues | TPM* | |
|
| normal | 7 | |
| germ cell tumor | 15 | |
| head and neck tumor | 22 | |
| leukemia | 10 | |
| lung tumor | 9 | |
| soft tissue/muscle tissue tumor | 7 | |
|
| Developmental Stage | |
| Tissues | TPM* | |
|
| adult | 5 | |
| fetus | 16 | |
|
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
| |
|
| Expression level of Protein (ref. Human Protein Atlas) |
|
| |
|
| RNA-Seq. | |
| Tissues | FPKM | |
|
| cerebral cortex | 3.2 | |
| kidney | 2.1 | |
| testis | 8.4 | |
|
| Cancer | |
| Tumor | Number of patients and Staining levels | |
| breast cancer | |
| carcinoid | |
| cervical cancer | |
| colorectal cancer | |
| endometrial cancer | |
| glioma | |
| head and neck cancer | |
| liver cancer | |
| lung cancer | |
| lymphoma | |
| melanoma | |
| ovarian cancer | |
| pancreatic cancer | |
| prostate cancer | |
| renal cancer | |
| skin cancer | |
| stomach cancer | |
| testis cancer | |
| thyroid cancer | |
| urothelial cancer | |
|
| RNA-seq colour codes |
|
|
Highly expressed RNAs (FPKM >50) | |
|
Moderately expressed RNAs (50> FPKM >10) | |
|
Lower expressed RNAs (10> FPKM >1) | |
|
The lowest expressed RNAs (FPKM value of 0 or 1) |
|
| Staining level colour codes |
|
|
Highly expressed protein | |
|
Moderately expressed protein | |
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Lower expressed protein | |
|
Not Detected |
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| |
|
| Disease |
|
| |
|
| No. | Disease Description | Ref. |
|
| 1 | (*605438, gene) Discs large-associated protein 2; DLGAP2 | OMIM |
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> Protein (NX_Q9P1A6)