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> Protein (NX_Q9P1Z2)
Protein (NX_Q9P1Z2)
Protein
Gene SymbolCALCOCO1 to neXtProt (NX_Q9P1Z2)
DescriptionCalcium-binding and coiled-coil domain-containing protein 1
Chromosome12
Location12q13.13 (54104903 ~ 54121529) to Ensembl
Sequene Features : Isoforms 4, Variants 72, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.armadillo repeat domain binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 6 more...
.intracellular membrane-bounded organelle
.cytoplasm
.nucleus
.nuclear chromatin
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 72 0
2014-09-19protein level
4 58 0
2014-05-27protein level
4 58 0
2014-02-25protein level
4 58 0
2013-12-09protein level
4 47 0
2013-11-01protein level
4 44 0
2013-09-12protein level
4 44 1
2013-08-17protein level
4 44 1
2013-07-15protein level
4 35 1
2013-06-11protein level
4 35 1
2013-02-12protein level
4 18 4
2012-12-20protein level
4 18 4
2012-10-30protein level
4 18 4
2012-10-07protein level
4 18 1
2012-08-24protein level
4 15 1
2012-07-28protein level
4 14 1
2012-06-08protein level
4 17 1
2012-05-07protein level
4 18 1
2012-04-10protein level
4 18 1
2012-01-13protein level
4 13 1
2011-12-20protein level
4 13 1
2011-11-11protein level
4 13 1
2011-08-23protein level
4 4 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9P1Z2-1
0 29 0 77288.5296
NX_Q9P1Z2-2
1 27 0 70934.7327
NX_Q9P1Z2-3
1 28 0 77159.4873
NX_Q9P1Z2-4
2 22 0 67500.6009
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-749920,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
2 EBI-749920,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
3 EBI-749920,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
4 EBI-749920,EBI-1048247 TBC1D15  
  .positive regulation of GTPase activity
.regulation of GTPase activity
.GTPase activator activity .extracellular exosome
.mitochondrion
.cytoplasm
5 EBI-749920,EBI-2805787 ISOC1  
  .N/A .catalytic activity .extracellular exosome
.peroxisome
6 EBI-749920,EBI-741885 CEP19  
  .N/A .N/A .ciliary basal body
.centriole
.spindle pole
7 EBI-749920,EBI-749800 DUSP13  
  .spermatogenesis
.meiotic nuclear division
.protein dephosphorylation
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites25
blood81
bone69
bone marrow20
brain320
cervix20
connective tissue207
embryonic tissue75
eye57
heart111
intestine146
kidney137
larynx255
liver58
lung146
lymph node66
mammary gland165
mouth317
muscle75
nerve64
ovary49
pancreas56
parathyroid194
pharynx24
pituitary gland60
placenta180
prostate68
salivary gland98
skin170
spleen280
stomach114
testis156
thymus853
thyroid128
trachea405
uterus193
vascular154
Health State
TissuesTPM*
normal179
adrenal tumor79
breast (mammary gland) tumor150
cervical tumor28
chondrosarcoma325
colorectal tumor133
gastrointestinal tumor92
germ cell tumor186
glioma102
head and neck tumor231
kidney tumor188
leukemia158
liver tumor83
lung tumor48
non-neoplasia196
ovarian tumor13
pancreatic tumor85
primitive neuroectodermal tumor of the CNS62
prostate cancer28
retinoblastoma21
skin tumor47
soft tissue/muscle tissue tumor15
uterine tumor122
Developmental Stage
TissuesTPM*
adult128
embryoid body85
blastocyst48
neonate160
fetus211
infant42
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue91.3
adrenal gland61.1
appendix44
bone marrow38.4
cerebral cortex61.6
colon42.9
duodenum46.9
esophagus76.9
gallbladder108.3
heart muscle105.2
kidney55.4
liver27.6
lung120
lymph node55.2
ovary98.4
pancreas38.8
placenta70.4
prostate71.1
salivary gland81.9
skin165.6
small intestine48.8
spleen68.4
stomach51
testis50.2
thyroid gland60.3
urinary bladder70.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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