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> Protein (NX_Q9P2K3)
Protein (NX_Q9P2K3)
Protein
Gene SymbolRCOR3 to neXtProt (NX_Q9P2K3)
DescriptionREST corepressor 3
Chromosome1
Location1q32.2 (211431719 ~ 211489727) to Ensembl
Sequene Features : Isoforms 4, Variants 70, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 70 8
2014-09-19protein level
4 48 8
2014-05-27protein level
4 47 8
2014-02-25protein level
4 47 6
2013-12-09protein level
4 42 6
2013-11-01protein level
4 39 4
2013-09-12protein level
4 39 4
2013-08-17protein level
4 39 4
2013-07-15protein level
4 24 4
2013-06-11protein level
4 24 4
2013-02-12protein level
4 11 12
2012-12-20protein level
4 11 12
2012-10-30protein level
4 13 12
2012-10-07protein level
4 13 3
2012-08-24protein level
4 11 3
2012-07-28protein level
4 11 3
2012-06-08protein level
4 11 3
2012-05-07protein level
4 6 3
2012-04-10protein level
4 6 3
2012-01-13protein level
4 3 3
2011-12-20protein level
4 3 3
2011-11-11protein level
4 3 3
2011-08-23protein level
4 3 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q9P2K3-1
0 19 4 55546.9318
NX_Q9P2K3-2
2 11 4 47729.7793
NX_Q9P2K3-3
0 20 4 61176.3639
NX_Q9P2K3-4
1 15 4 50345.4263
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-743428,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-743428,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
3 EBI-743428,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
4 EBI-743428,EBI-1045155 MAGEA6  
  .N/A .N/A .N/A
5 EBI-743428,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
6 EBI-743428,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
7 EBI-743428,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
8 EBI-743428,EBI-372619 GSE1  
  .N/A .N/A .N/A
9 EBI-743428,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
10 EBI-743428,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
11 EBI-743428,EBI-6658186 LCA5  
  .photoreceptor cell maintenance
.intraciliary transport
.protein transport
.protein complex binding .cilium
.microtubule organizing center
.cytoplasm
12 EBI-743428,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
13 EBI-743428,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
14 EBI-743428,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
15 EBI-743428,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
16 EBI-743428,EBI-3957793 PRDM14  
  .homeostasis of number of cells within a tissue
.regulation of DNA methylation
.negative regulation of fibroblast growth factor receptor signaling pathway
  + 11 more...
.metal ion binding
.methyltransferase activity
.DNA binding
.nucleoplasm
17 EBI-743428,EBI-10198848 LUZP4  
  .N/A .N/A .nucleus
18 EBI-743428,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
19 EBI-743428,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
20 EBI-743428,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
21 EBI-743428,EBI-719716 NINL  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.calcium ion binding .microtubule
.cytosol
.microtubule organizing center
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood16
bone13
brain71
cervix61
connective tissue20
ear434
embryonic tissue32
eye47
heart78
intestine47
kidney47
liver29
lung41
lymph node77
mammary gland6
mouth30
muscle56
ovary59
pancreas65
pharynx49
pituitary gland60
placenta49
prostate26
skin47
spleen56
stomach10
testis80
thymus62
thyroid107
trachea193
uterus51
vascular38
Health State
TissuesTPM*
normal60
bladder carcinoma56
cervical tumor86
chondrosarcoma24
colorectal tumor62
germ cell tumor34
head and neck tumor59
kidney tumor43
leukemia42
liver tumor31
lung tumor9
lymphoma13
non-neoplasia31
ovarian tumor52
pancreatic tumor28
primitive neuroectodermal tumor of the CNS70
skin tumor39
soft tissue/muscle tissue tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult40
embryoid body28
blastocyst32
neonate32
fetus84
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16
adrenal gland20.6
appendix20.1
bone marrow30
cerebral cortex17.7
colon16.2
duodenum19.3
esophagus16.3
gallbladder18.6
heart muscle20.5
kidney21.5
liver11.1
lung21.8
lymph node24.5
ovary30.9
pancreas11.7
placenta18.5
prostate31.3
salivary gland18.6
skin23.4
small intestine20.8
spleen24.3
stomach18.2
testis62.6
thyroid gland35.7
urinary bladder20.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisHigh
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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